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Validation of the Italian version of Parkinson’s Disease-Cognitive Rating Scale (PD-CRS)

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Abstract

Cognitive impairment (CI) is a frequent feature associated with both early and advanced stages of Parkinson’s disease (PD). An evaluation of cognitive functions is relevant to identify those parkinsonians at risk of developing dementia. In the present study, the Italian version of Parkinson’s Disease-Cognitive Rating Scale (PD-CRS) assessing fronto-subcortical and cortical cognitive functions in PD was validated in 387 parkinsonians and was used to test the empirical validity of the item 1.1 (cognitive impairment) of the Italian version of MDS-UPDRS as screening tool for CI in PD. PD-CRS was free from floor and ceiling effect. The mean PD-CRS score was 76.1 (mean cortical score, 24.5 ± 4.6; mean subcortical score, 51.5 ± 17.5). The internal consistency was satisfactory (α = 0.89); corrected item-total correlation was 0.570 (naming) to 0.696 (working memory). The correlation between PD-CRS and part I–IV of MDS-UPDRS was weak. The low agreement between classification of PD sample into patients with mild cognitive impairment (PD-MCI), dementia (PD-D) and normal cognition (PD-NC) according to scores of item 1.1 and classification according to cutoff scores of PD-CRS for PD-MCI, PD-D and PD-NC indicated a poor empirical validity of item 1.1 of MDS-UPDRS as cognitive screening tool for CI in PD (Κ = 0.114; weighted Κ = 0.17; SE of Κ = 0.038; 95 % confidence interval from 0.040 to 0.1895). The Italian version of PD-CRS is an easy, consistent and valid tool for assessment of the cognitive cortical and subcortical impairments in PD.

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Acknowledgment

This study has been funded by the Neureca Foundation.

Author information

Correspondence to Paolo Barone.

Additional information

On behalf of the IRIS Study Group.

Appendix: Investigators of IRIS Study Group

Appendix: Investigators of IRIS Study Group

Monica Bandettini di Poggio: Department of Neurosciences, Ophthalmology and Genetics, Centre for Movement Disorders, University of Genoa, Genoa, Italy.

Giovanni Fabbrini: Department of Neurology and Psychiatry, Sapienza University of Rome.

Flavio Di Stasio: Department of Neurology and Psychiatry, Sapienza University of Rome.

Michele Tinazzi:Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Universita` di Verona.

Tommaso Bovi: Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Universita` di Verona.

Silvia Ramat: Department of Neurosciences, University of Florence.

Sara Meoni: Department of Neurosciences, University of Florence.

Gianni Pezzoli: Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.

Chiara Siri: Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.

Margherita Canesi: Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.

Paolo Martinelli: Dipartimento Scienze Neurologiche Universita` di Bologna Italy.

Cesa Lorella Maria Scaglione: Dipartimento Scienze Neurologiche Universita` di Bologna Italy.

Aroldo Rossi: Azienda Ospedaliera––Universita` di Perugia, Perugia (Italy).

Nicola Tambasco: Azienda Ospedaliera––Universita` di Perugia, Perugia (Italy).

Marina Picillo: Dipartimento di Scienze Neurologiche, Università Federico II, Napoli.

Letterio Morgante: Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Universita’ di Messina.

Francesca Morgante: Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Universita’ di Messina.

Rocco Quatrale: Neurology Unit University Hospital S. Annna Ferrara, Italy.

MariaChiara Sensi: Neurology Unit University Hospital S. Annna Ferrara, Italy.

Manuela Pilleri: Department for Parkinson disease, IRCCS San Camillo Venezia.

Roberta Biundo: Department for Parkinson disease, IRCCS San Camillo Venezia.

Giampietro Nordera: Casa di Cura Villa Margherita, Arcugnano (Vicenza) Italy.

Antonella Caria: Casa di Cura Villa Margherita, Arcugnano (Vicenza) Italy.

Claudio Pacchetti: Parkinson’s Dis. and Mov. Dis. Unit, Fondazione Istituto Neurologico Nazionale “C. Mondino”, IRCCS.

Roberta Zangaglia: Parkinson’s Dis. and Mov. Dis. Unit, Fondazione Istituto Neurologico Nazionale “C. Mondino”, IRCCS.

Leonardo Lopiano: Universita` degli Studi di Torino, Dipartimento di Neuroscienze, SCDU Neurologia 4.

Maurizio Zibetti: Universita` degli Studi di Torino, Dipartimento di Neuroscienze, SCDU Neurologia 4.

Mario Zappia: Dipartimento di Neuroscienze U.O.C. di Neurologia––Clinica Neurologica dell’Universita` degli Studi di Catania, Catania (Italy).

Alessandra Nicoletti: Dipartimento di Neuroscienze U.O.C. di Neurologia Clinica Neurologica dell’Universita` degli Studi di Catania, Catania (Italy).

Aldo Quattrone: Dipartimento di Scienze Mediche dell’Universita` degli Studi Magna Graecia, Catanzaro.

Maria Salsone: Dipartimento di Scienze Mediche dell’Universita` degli Studi Magna Graecia, Catanzaro.

Gianni Cossu: S. C. di Neurologia––A. O. “G. Brotzu” Cagliari.

Daniela Murgia: S. C. di Neurologia––A. O. “G. Brotzu” Cagliari.

Alberto Albanese: Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano.

Francesca Del Sorbo: Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano.

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Santangelo, G., Barone, P., Abbruzzese, G. et al. Validation of the Italian version of Parkinson’s Disease-Cognitive Rating Scale (PD-CRS). Neurol Sci 35, 537–544 (2014). https://doi.org/10.1007/s10072-013-1538-y

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Keywords

  • Parkinson’s disease
  • Cognitive dysfunctions
  • Mild cognitive impairment
  • Dementia
  • Parkinson's Disease Cognitive Rating Scale (PD-CRS)