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Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson’s disease: an fMRI study

Neurological Sciences volume 34, pages 2159–2166 (2013)Cite this article

Abstract

The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson’s disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on outcome evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.

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Acknowledgments

This work was supported by the project “CEITEC Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund. The participation of T.U. was supported by a research project of the Czech Science Foundation, no. P407/12/2432. The participation of J.V. was supported by the European Regional Development Fund Project FNUSA-ICRC (No.CZ.1.05/1.1.00/02.0123).

Ethical standards

The study has been approved by appropriate ethics committee and has therefore been performed in accordance with ethical standards laid down in the 1964 declaration of Helsinki.

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Authors and Affiliations

  1. CEITEC-Central European Institute of Technology, Behavioral and Social Neuroscience Research Group, Masaryk University, University Campus Bohunice, Building A4, Brno, Czech Republic

    Tomáš Gescheidt, Kristína Czekóová, Daniel J. Shaw & Martin Bareš

  2. Department of Neurology, Medical Faculty Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic

    Tomáš Gescheidt & Martin Bareš

  3. CEITEC-Central European Institute of Technology, Molecular and Functional Imaging Research Group, Masaryk University, Brno, Czech Republic

    Radek Mareček & Michal Mikl

  4. Institute of Psychology, Academy of Sciences of the Czech Republic, Brno, Czech Republic

    Tomáš Urbánek

  5. Department of Medical Imaging, Medical Faculty Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic

    Jiří Vaníček

  6. International Clinical Research Center (ICRC), St. Anne’s University Hospital, Brno, Czech Republic

    Jiří Vaníček

Authors
  1. Tomáš Gescheidt
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  2. Radek Mareček
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  3. Michal Mikl
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  4. Kristína Czekóová
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  5. Tomáš Urbánek
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  6. Jiří Vaníček
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  7. Daniel J. Shaw
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  8. Martin Bareš
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Correspondence to Martin Bareš.

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Gescheidt, T., Mareček, R., Mikl, M. et al. Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson’s disease: an fMRI study. Neurol Sci 34, 2159–2166 (2013). https://doi.org/10.1007/s10072-013-1439-0

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  • DOI: https://doi.org/10.1007/s10072-013-1439-0

Keywords

  • Parkinson’s disease
  • Iowa Gambling Task
  • Decision-making
  • Dopamine
  • fMRI
  • Psychophysiological interactions