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Chordoid meningioma: a retrospective series of seven consecutive cases

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Abstract

Chordoid meningioma is a rare variant of meningioma characterized by a more aggressive behavior. The present study documents the histological, radiological and clinical features of seven cases treated at the Policlinico Umberto I of Rome from 1999 to 2010. There were five males and two females. Most of the cases were located in the supratentorial space, especially the convexity. Surgical gross total resection was achieved in four cases. Of the remaining three cases, two relapsed and underwent further surgeries and adjuvant treatment. The MIB-1 index had a mean value of 7.5 (range 0.3–25.8). Tumors were composed of epithelioid cells or plump to spindle cells, forming cords, cribriforms or nests, in a mucoid matrix. All tumors showed diffuse positive immunoreactivity to vimentin and epithelial membrane antigen. Surgery is the first line of treatment for this kind of lesion. Gross total resection guaranteed a survival free from recurrences in our series. On the other hand, radiation therapy must be considered in patients submitted to a subtotal resection.

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References

  1. Perry A, Louis DN, Scheithauer BW, Budka H, Von Deimling A (2007) Meningiomas. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system. IARC, Lyon, pp 164–172

    Google Scholar 

  2. Epari S, Sharma MC, Sarkar C, Garg A, Gupta A, Mehta VS (2006) Chordoid meningioma, an uncommon variant of meningioma: a clinicopathologic study of 12 cases. J Neurooncol 78:263–269

    Article  PubMed  CAS  Google Scholar 

  3. Kepes JJ, Chen WY, Connors MH, Vogel FS (1988) ‘‘Chordoid’’ meningeal tumors in young individuals with peritumoral lymphoplasmacellular infiltrates causing systemic manifestations of the Castleman syndrome. A report of seven cases. Cancer 62(2):391–406

    Article  PubMed  CAS  Google Scholar 

  4. Kozler P, Benes V, Netuka D, Kramàr F, Hrabal P, Charvat F (2008) Chordoid meningioma, presentation of two case reports, review of the literature, and plea for data standardization. J Neurooncol 88(1):115–120

    Article  PubMed  CAS  Google Scholar 

  5. Bakar B, Sav A, Tekkok IH (2010) Giant chordoid meningioma symptomatic immediately after pregnancy: report of a rare case. Clin Neuropathol 29(3):163–168

    Article  PubMed  CAS  Google Scholar 

  6. Barresi V, Tuccari G (2009) Evaluation of neo-angiogenesis in a case of chordoid meningioma. J Neurooncol 95(3):445–447

    Article  PubMed  Google Scholar 

  7. Campos-Franco J, Otero E, Lopez-Garcia E, Abdulkader I, Gonzalez-Quintela A (2011) Chordoid meningioma in a patient with lymphangioleiomyomatosis. J Neuroncol 105(3):667–669

    Article  Google Scholar 

  8. Fukushima S, Terasaki M, Shigemori M (2008) Chordoid meningioma arising in the pineal region: a case report. Brain Tumor Pathol 25(2):91–95

    Article  PubMed  Google Scholar 

  9. Hayashi T, Haba R, Kushida Y, Kadota K, Katsuki N, Bando K, Miyai Y, Shibuya S, Funamoto Y, Shindo A, Miyake K, Tamiya T (2010) Cytopathological features of orbital intraosseous chordoid meningioma: report of a case and distinction from other myxoid/mucoid tumors. Diagn Cytopathol 38(11):818–821

    Article  PubMed  Google Scholar 

  10. Kaloshi G, Antonelli M, Vreto G, Lame A, Kerri I, Bushati T, Rroji A, Petrela M (2011) Report of two cases of chordoid meningioma in patients with Castleman syndrome. J Neurooncol 104(1):395–397

    Article  PubMed  Google Scholar 

  11. Kano T, Nakazato Y, Tamura M, Ohye C, Zama A, Saito F, Tomizawa S (2009) Ultrastructural and immunohistochemical study of an adult case of chordoid meningioma. Brain Tumor Pathol 26(1):37–42

    Article  PubMed  Google Scholar 

  12. Lee KH, Lall RR, Chandler JP, Bigio EH, Mao Q (2012) Pineal chordoid meningioma complicated by repetitive hemorrhage during pregnancy: case report and literature review. Neuropathol. doi:10.1111/j.1440-1789.2012.01337.x

    Google Scholar 

  13. Lin JW, Ho JT, Lin YJ, Wu YT (2010) Chordoid meningioma: a clinopathologic study of 11 cases at a single institution. J Neurooncol 100(3):465–473

    Article  PubMed  Google Scholar 

  14. Malloy KA, Chigbu DI (2011) Anterior temporal chordoid meningioma causing compressive optic neuropathy. Optom Vis Sci 88(5):645–651

    Article  PubMed  Google Scholar 

  15. Moiyadi AV, Sridhar E, Gupta T, Ramadwar M (2010) A primary optic nerve sheath chordoid meningioma. J Clin Neurosci 17(3):397–399

    Article  PubMed  Google Scholar 

  16. Sangoi AR, Dulai MS, Beck AH, Brat DJ, Vogel H (2009) Distinguishing chordoid meningioma from their histologic mimics: an immu- nohistochemical evaluation. Am J Surg Pathol 33(5):669–681

    Article  PubMed  Google Scholar 

  17. Sav A, Scheithauer BW (2000) Neuropathology of meningiomas. In: Pamir MN, Black PM, Fahlbusch R (eds) Meningiomas: a comprehensive text. Saunders Elsevier, Philadelphia, pp 107–108

    Google Scholar 

  18. Song KS, Park SH, Cho BK, Wang KC, Phi JH, Kim SK (2008) Third ventricular chordoid meningioma in a child. J Neurosurg Pediatr 2:269–272

    Article  PubMed  Google Scholar 

  19. Wilson JL, Ellis TL, Mott RT (2011) Chordoid meningioma of the third ventricle: a case report and review of the literature. Clin Neuropathol 30(2):70–74

    Article  PubMed  CAS  Google Scholar 

  20. Wind JJ, Jones RV, Roberti F (2010) Fourth ventricular chordoid meningioma. J Clin Neurosci 17(10):1301–1303

    Article  PubMed  Google Scholar 

  21. Xi S, Zhang Y, Lin S, Liang J, Zeng J, Wu Q (2012) Intraparenchymal chordoid meningioma: a case report and review of the literature. Int J Surg Pathol. doi:10.1177/1066896912449043

    PubMed  Google Scholar 

  22. Zhao SL, Li Y, Tian XY, Li Z, Huang Q, Li B (2011) Intraparenchymal cystic chordoid meningioma: a case report and review of the literature. Neuropathol 31(6):648–653

    Article  Google Scholar 

  23. Couce ME, Aker FV, Scheithauer BW (2000) Chordoid meningioma: a clinicopathologic study of 42 cases. Am J Surg Pathol 24(7):899–905

    Article  PubMed  CAS  Google Scholar 

  24. Donato G, Ferraro G, Signorelli F, Iofrida G, Lavano A, Amorosi A, Maltese L, Perrotta I, Tripepi S, Pardatscher K, Signorelli CD (2006) Chordoid meningioma: case report and literature review. Ultrastruct Pathol 30(4):309–314

    Article  PubMed  CAS  Google Scholar 

  25. Tena-Suck ML, Collado-Ortìz MA, Salinas-Lara C, García-López R, Gelista N, Rembao-Bojorquez D (2010) Chordoid meningioma: a report of ten cases. J Neurooncol 99:41–48

    Article  PubMed  Google Scholar 

  26. Louis DN, Scheithauer BW, Budka H, von Deimling A, Kepes JJ (2000) Meningiomas. In: Kleihues P, Cavenee WB (eds) Pathology and genetics of tumors of the nervous system. IARC, Lyon, pp 176–184

    Google Scholar 

  27. Pearson BE, Markert JM, Fisher WS, Guthrie BL, Fiveash JB, Palmer CA, Riley K (2008) Hitting a moving target: evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteria. Neurosurg Focus 24(5):E3

    Article  PubMed  Google Scholar 

  28. Smith SJ, Boddu S, Macarthur DC (2007) Atypical meningiomas: WHO moved the goalposts? Br J Neurosurg 21:588–592

    Article  PubMed  CAS  Google Scholar 

  29. Marcus HJ, Price SJ, Wilby M, Santarius T, Kirollos RW (2008) Radiotherapy as an adjuvant in the management of intracranial meningiomas: are we practising evidence-based medicine? Br J Neurosurg 22(4):520–528

    Article  PubMed  CAS  Google Scholar 

  30. Mair R, Morris K, Scott I, Carrol TA (2011) Radiotherapy for atypical meningiomas. J Neurosurg 115:811–819

    Article  PubMed  Google Scholar 

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Acknowledgments

We would like to thank Dr. Irene De Francesco for her aid in the preparation of the manuscript.

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Authors and Affiliations

  1. Department of Neurology and Psychiatry, Neurosurgery, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy

    Emiliano Passacantilli, Gennaro Lapadula, Federico Caporlingua, Jacopo Lenzi & Antonio Santoro

  2. Department of Pathology, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy

    Manila Antonelli

  3. Department of Radiology, Saint Andrea Hospital, “Sapienza” University of Rome, Rome, Italy

    Francesca Santoro

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  1. Emiliano Passacantilli
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  2. Gennaro Lapadula
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  3. Federico Caporlingua
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  4. Jacopo Lenzi
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  5. Manila Antonelli
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  6. Francesca Santoro
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  7. Antonio Santoro
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Correspondence to Federico Caporlingua.

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Passacantilli, E., Lapadula, G., Caporlingua, F. et al. Chordoid meningioma: a retrospective series of seven consecutive cases. Neurol Sci 34, 1985–1989 (2013). https://doi.org/10.1007/s10072-013-1431-8

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  • DOI: https://doi.org/10.1007/s10072-013-1431-8

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