Abstract
Although in literature almost 150 patients with Lance-Adams Syndrome (LAS) have been reported, neuroradiological evaluations were often performed in late stages and there is no serial study evaluating LAS from early stages. We herein report a serial neuroimaging study demonstrating early and transient involvement of cerebellum and thalami in a LAS patient. We may hypothesize that a transient cerebral hypoxia provoked a permanent synaptic rearrangements of the neuronal networks involved in the pathogenesis of post-hypoxic myoclonus in our patient.
References
Lance JW, Adams RD (1963) The syndrome of intention or action myoclonus as a sequel to hypoxic encephalopathy. Brain 86:111–136
Fahn S (1986) Posthypoxic action myoclonus: literature review update. Adv Neurol 43:157–169
Ferlazzo E, Gasparini S, Gambardella A, Labate A, Cianci V, Cherubini A, Lanza P, Quattrone A, Aguglia U (2012) Unilateral basal ganglia atrophy in a patient with tuberous sclerosis complex and hemichorea. Mov Disord 27:458–460
Tai KK, Bhidayasiri R (2007) Truong DD (2007) Post-hypoxic animal model of myoclonus. Parkinsonism Relat Disord 13:377–381
Werhahn KJ, Brown P, Thompson PD, Marsden CD (1997) The clinical features and prognosis of chronic posthypoxic myoclonus. Mov Disord 12:216–220
Zhang YX, Liu JR, Jiang B, Liu HQ, Ding MP, Song SJ, Zhang BR, Zhang H, Xu B, Chen HH, Wang ZJ, Huang JZ (2007) Lance–Adams syndrome: a report of two cases. J Zhejiang Univ Sci B 8:715–720
Arbelaez A, Castillo M, Mukherji SK (1999) Diffusion-weighted MR imaging of global cerebral anoxia. AJNR Am J Neuroradiol 20:999–1007
Frucht SJ, Trost M, Ma Y, Eidelberg D (2004) The metabolic topography of posthypoxic myoclonus. Neurology 62:1879–1881
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ferlazzo, E., Gasparini, S., Cianci, V. et al. Serial MRI findings in brain anoxia leading to Lance–Adams syndrome: a case report. Neurol Sci 34, 2047–2050 (2013). https://doi.org/10.1007/s10072-013-1356-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-013-1356-2