Neurological Sciences

, Volume 34, Issue 7, pp 1189–1195 | Cite as

A sequential impairment of cortical astrocytes and GABAergic neurons during ischemia is improved by mGluR1,5 activation

  • Zhan Liu
  • Wei Huo
  • Wei Sun
  • Manhua Lv
  • Fang Li
  • Zhiqiang Su
Original Article

Abstract

Ischemic brain cell death is presumably caused by excitotoxicity. In addition to an increase of glutamate release during ischemia, the deficiency of astrocytic glutamate-reuptake may cause glutamate accumulation, which results in GABAergic neurons being vulnerable to ischemia. To confirm this hypothesis, we studied the pathophysiological changes of cortical astrocytes and GABAergic neurons during ischemia as well as the prevention of their injuries. Ischemia led to the sequential impairments of astrocytic glutamate-transporter currents and GABAergic neuronal excitability. The changes were partially reversed by 3,5-DHPG, an agonist of type-I/V metabotropic glutamate receptors (mGluR). Thus, mGluR1,5 activation may be useful against the sequential impairment of cortical astrocytes and GABAergic neurons in an early stage of ischemia.

Keywords

Ischemia mGluR Astrocyte GABA neuron Glutamate transport and action potential 

Supplementary material

10072_2012_1220_MOESM1_ESM.doc (144 kb)
Supplementary material 1 (DOC 144 kb)

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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Zhan Liu
    • 1
  • Wei Huo
    • 1
  • Wei Sun
    • 1
  • Manhua Lv
    • 1
  • Fang Li
    • 1
  • Zhiqiang Su
    • 1
  1. 1.Department of NeurologyThe First Affiliated Hospital in Harbin Medical UniversityHarbinPeople’s Republic of China

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