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A sequential impairment of cortical astrocytes and GABAergic neurons during ischemia is improved by mGluR1,5 activation

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Abstract

Ischemic brain cell death is presumably caused by excitotoxicity. In addition to an increase of glutamate release during ischemia, the deficiency of astrocytic glutamate-reuptake may cause glutamate accumulation, which results in GABAergic neurons being vulnerable to ischemia. To confirm this hypothesis, we studied the pathophysiological changes of cortical astrocytes and GABAergic neurons during ischemia as well as the prevention of their injuries. Ischemia led to the sequential impairments of astrocytic glutamate-transporter currents and GABAergic neuronal excitability. The changes were partially reversed by 3,5-DHPG, an agonist of type-I/V metabotropic glutamate receptors (mGluR). Thus, mGluR1,5 activation may be useful against the sequential impairment of cortical astrocytes and GABAergic neurons in an early stage of ischemia.

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital in Harbin Medical University, 37 Yiyuan Street, Harbin, Heilongjiang, 150001, People’s Republic of China

    Zhan Liu, Wei Huo, Wei Sun, Manhua Lv, Fang Li & Zhiqiang Su

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  1. Zhan Liu
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  2. Wei Huo
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  3. Wei Sun
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  4. Manhua Lv
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  5. Fang Li
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Correspondence to Zhiqiang Su.

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Liu, Z., Huo, W., Sun, W. et al. A sequential impairment of cortical astrocytes and GABAergic neurons during ischemia is improved by mGluR1,5 activation. Neurol Sci 34, 1189–1195 (2013). https://doi.org/10.1007/s10072-012-1220-9

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  • DOI: https://doi.org/10.1007/s10072-012-1220-9

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