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Assessment of health-related quality of life in patients with myasthenia gravis in Belgrade (Serbia)

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Abstract

The aim of this study was to assess factors that might influence the health-related quality of life (HRQoL) in patients with myasthenia gravis (MG). A cross-sectional study was performed including 230 consecutive patients with MG. Severity of the disease was estimated according to the MGFA classification and QMG score. HRQoL was assessed by the SF-36 questionnaire. Depressive and anxiety symptoms were assessed using the Hamilton rating scales for depression and anxiety, respectively. Social support was measured by the Multidimensional Scale of Perceived Social Support (MSPSS), and acceptance of the disease by the Acceptance of Illness Scale. The significant demographic predictors of worse HRQoL in MG patients were older age (p = 0.025) and lower education (p = 0.012). Among clinical features, significant independent contributing factors of worse HRQoL were more severe form of the disease according to MGFA (p = 0.001) and higher QMG score (p = 0.001). Finally, psychosocial predictors of worse quality of life were lower MSPSS score (p = 0.001), poor acceptance of the disease (p = 0.001), as well as higher levels of anxiety and depression (p = 0.001). Our study revealed that the HRQoL in patients with MG is similarly reduced in its psychological and physical aspects. These results may have a practical implication pointing out that different aspects of psychosocial support should be added to the regular therapeutic protocols.

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References

  1. Meriggioli M, Sanders D (2009) Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet Neurol 8:475–490

    Article  PubMed  CAS  Google Scholar 

  2. Padua L, Evoli A, Aprile I, Caliandro P, Mazza S, Padua R et al (2001) Health-related quality of life in patients with myasthenia gravis and the relationship between patient-oriented assessment and conventional measurements. Neurol Sci 22:363–369

    Article  PubMed  CAS  Google Scholar 

  3. Mullins L, Carpentier M, Paul R, Sanders D (2008) Disease-specific measure of quality of life for myasthenia gravis. Muscle Nerve 38:947–956

    Article  PubMed  Google Scholar 

  4. Paul RH, Nash JM, Cohen R, Gilchist J, Goldstein J (2001) Quality of life and well-being of patients with myasthenia gravis. Muscle Nerve 24:512–516

    Article  PubMed  CAS  Google Scholar 

  5. Leonardi M, Raggi A, Antozzi C, Confalonieri P, Maggi L, Cornelio F et al (2010) The relationship between health, disability and quality of life in myasthenia gravis: results from an Italian study. J Neurol 257:98–102

    Article  PubMed  Google Scholar 

  6. Raggi A, Leonardi M, Mantegazza R, Casale S, Fioravanti G (2009) Social support and self-efficacy in patients with myasthenia gravis: a common pathway towards positive health outcomes. Neurol Sci 31:41–45

    Article  PubMed  Google Scholar 

  7. Raggi A, Leonardi M, Antozzi C, Confaloineri P, Maggi L, Cornelio F et al (2010) Concordance between severity of disease, disability and health-related quality of life in myasthenia gravis. Neurol Sci 31:41–45

    Article  PubMed  Google Scholar 

  8. Drulovic J, Pekmezovic T, Matejic B, Mesaros S, Manigoda M, Dujmovic I et al (2007) Quality of life in patients with multiple sclerosis in Serbia. Acta Neurol Scand 115:147–152

    Article  PubMed  CAS  Google Scholar 

  9. Peric S, Rakocevic-Stojanovic V, Stevic Z, Basta I, Pavlovic S, Vujanac V et al (2010) Health-related quality of life in patients with myotonic dystropy type 1 and amyotrophic lateral sclerosis. Acta Neurol Belg 110:71–77

    PubMed  CAS  Google Scholar 

  10. Rostedt A, Padua L, Stalberg E (2006) Validation of the Swedish version of the disease-specific Myasthenia Gravis Questionnaire. Neurol Sci 27:91–96

    Article  PubMed  CAS  Google Scholar 

  11. Rostedt A, Padua L, Stalberg EV (2006) Correlation between regional myasthenic weakness and mental aspects of quality of life. Eur J Neurol 13:191–193

    Article  PubMed  CAS  Google Scholar 

  12. Twork S, Wiesmeth S, Klewer J, Pohlau D, Kuglerg J (2010) Quality of life and life circumstances in German myasthenia gravis patients. Health Qual Life Outcomes 8:129

    Article  PubMed  Google Scholar 

  13. Winter Y, Schepelmann K, Spottke AE, Claus D, Grothe C, Schroder R et al (2010) Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy. J Neurol 257:1473–1481

    Article  PubMed  Google Scholar 

  14. Kulkantrakorn K, Sawanyawisuth K, Tiamkao S (2010) Factors correlating quality of life in patients with myasthenia gravis. Neurol Sci 31:571–573

    Article  PubMed  Google Scholar 

  15. Chen YT, Chang Y, Chiu HC, Yeh JH (2011) Psychosocial aspects in myasthenic patients treated by plasmapheresis. J Neurol 258:1240–1246

    Article  PubMed  Google Scholar 

  16. Lavrnic D, Jerebinski M, Rakocevic-Stojanovic V, Stevic Z, Lavrnic S, Pavlovic S et al (1999) Epidemiological and clinical characteristics of myasthenia gravis in Belgrade, Yugoslavia (1983–1992). Acta Neurol Scand 100:168–174

    Article  PubMed  CAS  Google Scholar 

  17. Lavrnic D, Losen M, Vujic A, De Baets M, Hajdukovic LJ, Stojanovic V et al (2005) The features of myasthenia gravis with autoantibodies to MuSK. J Neurol Neurosurg Psychiatry 76:1099–1102

    Article  PubMed  CAS  Google Scholar 

  18. Basta I, Pekmezovic T, Padua L, Stojanovic V, Stevic Z, Nikolic A et al (2010) Validation of Serbian version of the disease-specific Myasthenia Gravis Questionnaire. Acta Neurol Scand 122:110–114

    Article  PubMed  CAS  Google Scholar 

  19. Osserman KE, Genkins G (1971) Studies in myasthenia gravis: review of twenty-year experience in over 1200 patients. Mt Sinai J Med 38:497–537

    PubMed  CAS  Google Scholar 

  20. Stalberg E (1980) Clinical electrophysiology in myasthenia gravis. J Neurol Neurosurg Psychiatry 43:622–633

    Article  PubMed  CAS  Google Scholar 

  21. Jeretzki A, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS et al (2000) Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Neurology 55:16–23

    Article  Google Scholar 

  22. Barohn RJ, McIntire D, Herbelin L, Wolfe GI, Nations S, Bryan W (1998) Reliability testing of the Quantitative Myasthenia Gravis Score. Ann N Y Acad Sci 841:769–772

    Article  PubMed  CAS  Google Scholar 

  23. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62

    Article  PubMed  CAS  Google Scholar 

  24. Hamilton M (1959) The assessment of anxiety status by rating. Br J Med Psychol 32:50–55

    Article  PubMed  CAS  Google Scholar 

  25. Felton BJ, Revenson TA (1984) Coping with chronic illness: a study of illness controllability and influence of coping strategies on psychological adjustment. J Consult Clin Psychol 2:343–353

    Google Scholar 

  26. Zimet GD, Powell SS, Farley GK et al (1990) Psychometric characteristics of the MSPSS. J Pers Assess 55:610–617

    PubMed  CAS  Google Scholar 

  27. http://www.qualitymetric.com SF-36 health survey (original version) language recalls. Accessed 01 Jan 2008

  28. Ware JE, Sherbourne CD (1992) 36-Item Short-Form Health Survey (SF-36). Conceptual framework and item selection. Med Care 30:473–483

    Article  PubMed  Google Scholar 

  29. Kulaksizoglu IB (2007) Mood and anxiety disorders in patients with myasthenia gravis: aetiology, diagnosis and treatment. CNS Drugs 21:473–481

    Article  PubMed  CAS  Google Scholar 

  30. Pekmezovic T, Svetel M, Ivanovic N, Dragasevic N, Petrovic I, Kisic-Tepavcevic D et al (2009) Quality of life in patients with focal dystonia. Clin Neurol Neurosurg 111:161–164

    Article  PubMed  Google Scholar 

  31. Svetel M, Pekmezovic T, Tomic A, Kresojevic N, Potrebic A, Jesic R et al (2011) Quality of life in patients with treated and clinically stable Wilson’s disease. Mov Disord 26:1503–1508

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This investigation was supported by the Ministry of Science of the Republic of Serbia (Grants No 175087 and 175083).

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Authors and Affiliations

  1. Neurology Clinic, Faculty of Medicine, Clinical Centre of Serbia, University of Belgrade, Dr Subotica 6, 11000, Belgrade, Serbia

    Ivana Z. Basta, Stojan Z. Perić, Vidosava M. Rakočević-Stojanović, Zorica D. Stević & Dragana V. Lavrnić

  2. Faculty of Medicine, Institute of Epidemiology, University of Belgrade, Visegradska 26A, 11000, Belgrade, Serbia

    Tatjana D. Pekmezović & Darija B. Kisić-Tepavčević

Authors
  1. Ivana Z. Basta
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  2. Tatjana D. Pekmezović
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  3. Stojan Z. Perić
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  4. Darija B. Kisić-Tepavčević
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  5. Vidosava M. Rakočević-Stojanović
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  6. Zorica D. Stević
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  7. Dragana V. Lavrnić
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Correspondence to Dragana V. Lavrnić.

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Basta, I.Z., Pekmezović, T.D., Perić, S.Z. et al. Assessment of health-related quality of life in patients with myasthenia gravis in Belgrade (Serbia). Neurol Sci 33, 1375–1381 (2012). https://doi.org/10.1007/s10072-012-1170-2

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  • DOI: https://doi.org/10.1007/s10072-012-1170-2

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