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Association study of polymorphisms in the cyclooxygenase-2 gene and Alzheimer’s disease risk in Chinese

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Abstract

To determine if polymorphisms (−765G/C, −1195G/A and 8473T/C) of the cyclooxygenase-2 (COX-2) gene can be associated with Alzheimer disease (AD). The frequency of the polymorphisms was determined in 244 cases and 226 controls. The results revealed that the distributions of COX-2 −765G/C and 8473T/C polymorphisms were statistically not significant between AD cases and controls. The genotype distributions and allele frequencies of COX-2 −1195G/A polymorphism in the cases were statistically significantly different from the controls (P < 0.05). The A/A distribution and A allele frequency were significantly lower in the AD group. COX-2 −1195AA carriers showed a one-third lower risk of developing AD as compared to those with −1195GG and GA genotypes (OR = 0.3, 95 % CI 0.194–0.465, P = 0.000). This study suggested that −1195G/A polymorphism of the COX-2 gene is associated with the risk of AD, and the A allele represents a protective factor in patients with AD.

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References

  1. Duyckaerts C, Delatour B, Potier MC (2009) Classification and basic pathology of Alzheimer disease. Acta Neuropathol 118:5–36

    Article  PubMed  CAS  Google Scholar 

  2. Iqbal K, Grundke-Iqbal I (2011) Opportunities and challenges in developing Alzheimer disease therapeutics. Acta Neuropathol 122:543–549

    Article  PubMed  CAS  Google Scholar 

  3. Brouwers N, Sleegers K, Van Broeckhoven C (2008) Molecular genetics of Alzheimer’s disease: an update. Ann Med 40:562–583

    Article  PubMed  CAS  Google Scholar 

  4. Lee JH, Cheng R, Barral S et al (2011) Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals. Arch Neurol 68:320–328

    Article  PubMed  Google Scholar 

  5. Launer L (2003) Nonsteroidal anti-inflammatory drug use and the risk for Alzheimer’s disease: dissecting the epidemiological evidence. Drugs 63:731–739

    Article  PubMed  Google Scholar 

  6. Anthony JC, Breitner JC, Zandi PP et al (2000) Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study. Neurology 54:2066–2071

    Article  PubMed  CAS  Google Scholar 

  7. Etminan M, Gill S, Samii A (2003) Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer’s disease: systematic review and meta-analysis of observational studies. BMJ 327:128

    Article  PubMed  CAS  Google Scholar 

  8. in ’t Veld BA, Launer LJ, Breteler MM et al (2002) Pharmacologic agents associated with a preventive effect on Alzheimer’s disease: a review of the epidemiologic evidence. Epidemiol Rev 24:248–268

    Google Scholar 

  9. Pasinetti GM, Aisen PS (1998) Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer’s disease brain. Neuroscience 87:319–324

    Article  PubMed  CAS  Google Scholar 

  10. Yagami T, Ueda K, Asakura K et al (2001) Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol 134:673–681

    Article  PubMed  CAS  Google Scholar 

  11. Andersen K, Launer LJ, Ott A et al (1995) Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer’s disease? The Rotterdam Study. Neurology 45:1441–1445

    Article  PubMed  CAS  Google Scholar 

  12. in ’t Veld BA, Ruitenberg A, Hofman A et al (2001) Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer’s disease. N Engl J Med 345:1515–1521

    Google Scholar 

  13. Abdullah L, Crawford F et al (2005) The cyclooxygenase 2 −765 C promoter allele is a protective factor for Alzheimer’s disease. Neurosci Lett 395:240–243

    Article  PubMed  Google Scholar 

  14. Courivaud C, Bamoulid J, Ferrand C et al (2011) The COX-2 gene promoter polymorphism −765 delays CD4 T-cell reconstitution after lymphocyte depletion with antithymocyte globulins. Hum Immunol 72:1060–1063

    Article  PubMed  CAS  Google Scholar 

  15. Liu F, He Y, Peng X et al (2010) Association of the 8473T>C cyclooxygenase-2 (COX-2) gene polymorphism with lung cancer risk in Asians. Asian Pac J Cancer Prev 11:1257–1262

    PubMed  Google Scholar 

  16. Agachan Cakmakoglu B, Attar R, Kahraman OT et al (2011) Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk. Mol Biol Rep 38:3481–3486

    Article  PubMed  Google Scholar 

  17. McKhann G, Drachman D, Folstein M et al (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34:939–944

    Article  PubMed  CAS  Google Scholar 

  18. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorder, Fourth Edition, Text Revision. American Psychiatric Association, Washington DC

  19. Lee KH, Kim HS, El-Sohemy A et al (2006) Cyclooxygenase-2 genotype and rheumatoid arthritis. J Rheumatol 33:1231–1234

    PubMed  CAS  Google Scholar 

  20. Zhang X, Miao X, Tan W et al (2005) Identification of functional genetic variants in cyclooxygenase 2 and their association with risk of esophageal cancer. Gastroenterology 129:565–576

    PubMed  CAS  Google Scholar 

  21. Hu Z, Miao X, Ma H et al (2005) A common polymorphism in the 3′ UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. Lung Cancer 48:11–17

    Article  PubMed  CAS  Google Scholar 

  22. Zheng J, Chen S, Jiang L et al (2011) Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population. Eur J Haematol 87:486–493

    Article  PubMed  CAS  Google Scholar 

  23. He J, Zhang Q, Ren Z et al (2012) Cyclooxygenase-2 −765G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population. Mol Biol Rep 39:4163–4168

    Article  PubMed  CAS  Google Scholar 

  24. Ma SL, Tang N, Zhang YP et al (2008) Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer’s disease in Chinese. Neurobiol Aging 29:856–860

    Article  PubMed  CAS  Google Scholar 

  25. Gong Z, Bostick RM, Xie D et al (2009) Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma. Int J Colorectal Dis 24:647–654

    Article  PubMed  Google Scholar 

  26. Upadhyay R, Jain M, Kumar S et al (2009) Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squamous cell carcinoma. Mutat Res 663:52–59

    Article  PubMed  CAS  Google Scholar 

  27. Mandal RK, Mittal RD (2011) Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort. Arch Med Res 42:620–626

    Article  PubMed  CAS  Google Scholar 

  28. Chan IH, Tang NL, Leung TF et al (2007) Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. Allergy 62:802–809

    Article  PubMed  CAS  Google Scholar 

  29. Lira MG, Mazzola S, Tessari G et al (2007) Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. Br J Dermatol 157:49–57

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China

    Wenlu Tang

  2. Department of Pharmacology, School of Medicine, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, China

    Lirong Zhang

  3. Department of Pharmacology, Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China

    Meixia He & Bo Yang

  4. Department of Pharmacy, The Fourth Affiliated Hospital, Zhengzhou University, Zhengzhou, China

    Kankan Wei

  5. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China

    Ming Yin

Authors
  1. Wenlu Tang
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  2. Meixia He
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  3. Bo Yang
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  4. Kankan Wei
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  5. Ming Yin
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  6. Lirong Zhang
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Corresponding author

Correspondence to Lirong Zhang.

Additional information

W. Tang and M. He contributed equally to this work as co-first authors.

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Tang, W., He, M., Yang, B. et al. Association study of polymorphisms in the cyclooxygenase-2 gene and Alzheimer’s disease risk in Chinese. Neurol Sci 34, 695–699 (2013). https://doi.org/10.1007/s10072-012-1115-9

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  • DOI: https://doi.org/10.1007/s10072-012-1115-9

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