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Hypoglycemia-induced hemichorea in a patient with Fahr’s syndrome

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Abstract

Non-ketotic hyperglycemia may be a cause of hemiballism-hemichorea. We present an elderly female type II diabetic patient with right-sided hemiballism-hemichorea of acute onset during hypoglycemia following insulin overtreatment of non-ketotic hyperglycemia. Brain computerized tomography and magnetic resonance imaging scans revealed characteristic hyperdensity and T1 hyperintensity, respectively, in the left basal ganglia, in addition to pallido-dentate calcifications, suggestive of Fahr’s syndrome. Although extremely rare, hypoglycemia may be a cause of hemiballism-hemichorea especially in the presence of predisposing factors such as previous hyperglycemic episodes and Fahr’s syndrome.

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References

  1. Postuma RB, Lang AE (2003) Hemiballism: revisiting a classic disorder. Lancet Neurol 2:661–668

    Article  PubMed  Google Scholar 

  2. Cardoso F, Seppi K, Mair KJ, Wenning GK, Powe W (2006) Seminar on choreas. Lancet Neurol 5:589–602

    Article  PubMed  Google Scholar 

  3. Folstein M, Folstein S, McHugh PR (1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Article  PubMed  CAS  Google Scholar 

  4. Mattis S (1976) Mental Status Examination for organic mental syndrome in the elderly patients. In: Bellack L, Karasu TB (eds) Geriatric psychiatry: a handbook for psychiatrists and primary care physicians. Grune and Stratton, New York, pp 77–121

    Google Scholar 

  5. Chang CV, Feliccio AC, Godeiro CDO Jr, Matsubara LS, Duarte DR, Ferraz HB, Okoshi MP (2007) Chorea-ballism as a manifestation of decompensated type 2 diabetes mellitus. Am J Med Sci 333:175–177

    Article  PubMed  Google Scholar 

  6. Koh YHM, Lim WS, Seng TT, Sitoh Y-Y (2007) An unusual case of non-ketotic hyperglycemia presenting as hemichorea. JAGS 55:1691–1693

    Google Scholar 

  7. Felicio AC, Chang CV, Godeiro-Junior C, Okoshi MP, Ferraz HB (2008) Hemichorea-hemiballism as the first presentation of type 2 diabetes mellitus. Arq Neuropsiquiatr 66:249–250

    Article  PubMed  Google Scholar 

  8. Piccolo I, Defanti CA, Soliveri P, Volontè MA, Cislaghi G, Girotti F (2003) Cause and course in a series of patients with sporadic chorea. J Neurol 250:429–435

    Article  PubMed  Google Scholar 

  9. Oh SH, Lee KY, Im JH, Lee MS (2002) Chorea associated with non-ketotic hyperglycemia and hyperintensity basal ganglia lesion on T1-weighted brain MRI study: a meta-analysis of 53 cases including 4 present cases. J Neurol Sci 200:57–62

    Article  PubMed  Google Scholar 

  10. Pisani A, Diomedi M, Rum A, Cianciulli P, Floris R, Orlacchio A, Bernardi G, Calabresi P (2005) Acanthocytosis as a predisposing factor for non-ketotic hyperglycaemia induced chorea-ballism. J Neurol Neurosurg Psychiatry 76:1717–1719

    Article  PubMed  CAS  Google Scholar 

  11. Chu K, Kang D-W, Kim D-E, Park S-H, Roh J-K (2002) Diffusion-weighted and gradient echo magnetic resonance findings of hemichorea-hemiballismus associated with diabetic hyperglycemia: a hyperviscosity syndrome? Arch Neurol 59:448–452

    Article  PubMed  Google Scholar 

  12. Kandiah N, Tan K, Lim CCT, Venketasubramanian N (2009) Hyperglycemic choreoathetosis: role of the putamen in pathogenesis. Mov Disord 24:915–919

    Article  PubMed  Google Scholar 

  13. Nath J, Jambhekar K, Rao C, Armitano E (2006) Radiological and pathological changes in hemiballism-hemichorea with striatal hyperintensity. J Magn Reson Imaging 23:564–568

    Article  PubMed  Google Scholar 

  14. Shan DE, Ho DM, Chang C, Pan HC, Teng MM (1998) Hemichorea-hemiballism: an explanation for MR signal changes. Am J Neuroradiol 19:863–870

    PubMed  CAS  Google Scholar 

  15. Chang K-H, Tsou J-C, Chen S-T, Ro L-S, Lyu R-K, Chang H-S, Hsu W-C, Chen C-M, Wu W-R, Chen C-J (2010) Temporal features of magnetic resonance imaging and spectroscopy in non-ketotic hyperglycemic chorea-ballism patients. Eur J Neurol 17:589–593

    Article  PubMed  Google Scholar 

  16. Battisti C, Forte F, Rubenni E, Dotti MT, Bartali A, Gennari P, Federico A, Cerase A (2009) Two cases of hemichorea-hemiballism with nonketotic hyperglycemia: a new point of view. Neurol Sci 30:179–183

    Article  PubMed  Google Scholar 

  17. Cherian A, Thomas B, Baheti NN, Chemmanam T, Kesavadas C (2009) Concepts and controversies in nonketotic hyperglycemia-induced hemichorea: further evidence from susceptibility-weighted MR imaging. J Magn Reson Imaging 29:699–703

    Article  PubMed  Google Scholar 

  18. Wang J-H, Wu T, Deng B-Q, Zhang Y-W, Zhang P, Wang Z-K (2009) Hemichorea-hemiballismus associated with nonketotic hyperglycemia: a possible role of inflammation. J Neurol Sci 284:198–202

    Article  PubMed  Google Scholar 

  19. Lai SL, Tseng YL, Hsu MC, Chen SS (2004) Magnetic resonance imaging and single-photon emission computed tomography changes in hypoglycaemia-induced chorea. Mov Disord 19:475–478

    Article  PubMed  Google Scholar 

  20. Wolz M, Reichmann H, Reuner U, Storch A, Gerber J (2010) Hypoglycemia-induced choreoathetosis associated with hyperintense basal ganglia lesions in T1-weighted brain MRI. Mov Disord 25:966–968

    Article  PubMed  Google Scholar 

  21. Hsu JL, Wang HC, Hsu WC (2004) Hyperglycemia-induced unilateral basal ganglia lesions with and without hemichorea: a PET study. J Neurol 251:1486–1490

    Article  PubMed  Google Scholar 

  22. el Maghraoui A, Birouk N, Zaim A, Slassi I, Yahyaoui M, Chkili T (1995) Fahr syndrome and dysparathyroidism. 3 cases. Presse Med 24:1301–1304

    PubMed  Google Scholar 

  23. Kang JH, Kang SY, Choi JC, Lee SS, Kim JS (2005) Chorea triggered by hyperglycemia in a maternally inherited diabetes and deafness (MIDD) patient with the A3243G mutation of mitochondrial DNA and basal ganglia calcification. J Neurol 252:103–105

    Article  PubMed  Google Scholar 

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Correspondence to George P. Paraskevas.

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Paraskevas, G.P., Vlachos, G.S., Vassilopoulou, S. et al. Hypoglycemia-induced hemichorea in a patient with Fahr’s syndrome. Neurol Sci 33, 1397–1399 (2012). https://doi.org/10.1007/s10072-012-1096-8

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  • DOI: https://doi.org/10.1007/s10072-012-1096-8

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