Abstract
Migraine has complex relationships with cerebrovascular and cardiovascular disorders but also with cardiac anomalies. Patients affected by migraine with aura have an increased prevalence of right-to-left shunt due to patent foramen ovale or pulmonary arteriovenous malformations. The association between ischemic heart disease, cardiovascular mortality and migraine remains unsettled. The debate focuses on a physiopathological link between migraine and cardiovascular diseases or a higher prevalence of risk factors in migraineurs.
Similar content being viewed by others
References
Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 339:b3914–b3925
Kruit MC, Buchem MA, Launer LJ, Terwindt GM, Ferrari MD (2010) Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study. Cephalalgia 30:129–136
Schwedt TJ, Demaerschalk BM, Dodick DW (2008) Patent foramen ovale and migraine: a quantitative systematic review. Cephalalgia 28:531–540
Schwedt T (2009) The migraine association with cardiac anomalies, cardiovascular disease and stroke. Neurol Clin 27(2):513–523
Sharma A, Gheewala N, Silver P (2011) Role of patent foramen ovale in migraine etiology and treatment: a review. Echocardiography 28(8):913–917
Dowson A, Mullen MJ, Peatfield R, Muir K, Khan AA, Wells C, Lipscombe SL, Rees T, De Giovanni JV, Morrison WL, Hildick-Smith D, Elrington G, Hillis WS, Malik IS, Rickards A (2008) Migraine Intervention With STARFlex Technology (MIST) trial: a prospective, multicenter, double-blind, sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache. Circulation 117(11):1397–1404
Rose KM, Carson AP, Sanford CP, Stang PE, Brown CA, Folsom AR, Szklo M (2004) Migraine and other headaches. Associations with Rose angina and coronary heart disease. Neurology 63:2233–2239
Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291
Kurth T, Gaziano M, Cook NR, Bubes V, Logroscino G, Diener HC, Buring JE (2007) Migraine and risk of cardiovascular disease in men. Arch Intern Med 167:795–801
Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB (2010) Migraine and cardiovascular disease. Neurology 74:628–635
Bigal ME (2011) Migraine and cardiovascular disease. Arq Neuropsiquiatr 69(1):122–129
Wiehe M, Fuchs SC, Moreira LB, Moraes RS, Fuchs FD (2002) Migraine is more frequent in individuals with optimal and normal blood pressure: a population-based study. J Hypertens 20:1303–1306
Tzourio C, Gagnière B, El Amrani M, Alpérovitch A, Bousser MG (2003) Relationship between migraine, blood pressure and carotid thickness. A population-based study in the elderly. Cephalalgia 23:914–920
Bond DS, Roth J, Nash JM, Wing RR (2011) Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment. Obes Rev 12:e362–e371
Bigal ME, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545–550
Bigal ME, Tsang A, Loder E, Serrano D, Reed ML, Lipton RB (2007) Body mass index and episodic headaches: a population-based study. Arch Intern Med 167:1964–1970
Bigal ME, Lipton RB, Holland PR, Goadsby PJ (2007) Obesity, migraine and chronic migraine: possible mechanisms of interaction. Neurology 68:1851–1861
Peterlin BL, Rosso AL, Rapoport AM, Scher AI (2010) Obesity and migraine: the effect of age, gender and adipose tissue distribution. Headache 50:52–62
Mattsson P (2007) Migraine headache and obesity in women aged 40–74 years: a population-based study. Cephalalgia 27:877–880
Keith SW, Wang C, Fontaine KR, Cowan CD, Allison DB (2008) BMI and headache among women: results from 11 epidemiologic datasets. Obesity 16(2):377–383
Ford ES, Li C, Pearson WS, Zhao G, Strine TW, Mokdad AH (2008) Body mass index and headaches: findings from a national sample of US adults. Cephalalgia 28:1270–1276
Winter AC, Berger K, Buring JE, Kurth T (2009) Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia 29:269–278
Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE (2008) Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 337:a636–a745
Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620
Rist PM, Tzourio C, Kurth T (2011) Association between lipid levels and migraine: cross-sectional analysis in the Epidemiology of Vascular Ageing Study. Cephalalgia 31:1459–1465
Conflict of interest
The authors certify that there is no actual or potential conflict of interest in relation to this article.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pierangeli, G., Giannini, G., Favoni, V. et al. Migraine and cardiovascular diseases. Neurol Sci 33 (Suppl 1), 47–50 (2012). https://doi.org/10.1007/s10072-012-1040-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-012-1040-y