Skip to main content

Advertisement

SpringerLink
Log in

Migraine: risk factor and comorbidity

  • MIGRAINE AS A RISK FACTOR
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

The burden of migraine strongly increases considering its linkage with other psychiatric, neurological, cardiovascular and cerebrovascular diseases. Migraine is positively associated with many disorders: some are confirmed by several studies whereas others remain uncertain or controversial. The association with some disorders is not simply due to concomitance but it implies a linkage in terms of causality. Highlighting these relationships is important to improve treatment strategies, broaden our knowledge of the pathophysiology and understand if migraine is per se a modifiable risk factor for some disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jensen R, Stovner LJ (2008) Epidemiology and comorbidity of headache. Lancet Neurol 7:354–361

    Article  PubMed  Google Scholar 

  2. Wang SJ, Chen PK, Fuh JL (2010) Comorbidities of migraine. Front Neurol 1:1–9

    Google Scholar 

  3. Cannon PR, Larner AJ (2011) Migraine and restless legs syndrome: is there an association? J Headache Pain 12:405–409

    Article  PubMed  Google Scholar 

  4. Antonaci F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A (2011) Migraine and psychiatric comorbidity: a review of clinical findings. J Headache Pain 12:115–125

    Article  PubMed  Google Scholar 

  5. Baskin SM, Smitherman TA (2009) Migraine and psychiatric disorders: comorbidities, mechanism, and clinical applications. Neurol Sci 30(Suppl 1):S61–S65

    Article  PubMed  Google Scholar 

  6. Holland J, Agius M, Zaman R (2011) Prevalence of co-morbid bipolar disorder and migraine in a regional hospital psychiatric outpatient department. Psychiatr Danub 23(Suppl 1):S23–S24

    PubMed  Google Scholar 

  7. D’Andrea G, Ostuzzi R, Francesconi F, Musco F, Bolner A, d’Onofrio F, Colavito D (2009) Migraine prevalence in eating disorders and pathophysiological correlations. Neurol Sci 30(Suppl 1):S55–S59

    Article  PubMed  Google Scholar 

  8. Seidel S, Karwautz A, Wagner G, Zormann A, Eder H, Huemer J, Nattiashvili S, Wöber C, Wöber-Bingöl Ç (2011) Migraine in patients with eating disorders: a study using a sister-pair comparison design. Headache 51(2):220–225

    Article  PubMed  Google Scholar 

  9. Modgill G, Jette N, Wang JL, Becker WJ, Patten SB (2011) A population-based longitudinal community study of major depression and migraine. Headache (Epub ahead of print)

  10. Ratcliffe GE, Murray WE, Jacobi F, Belik SL, Sareen J (2009) The relationship between migraine and mental disorders in a population-based sample. Gen Hosp Psychiatry 31:14–19

    Article  PubMed  Google Scholar 

  11. Mercante JPP, Peres MFP, Bernik MA (2011) Primary headaches in patients with generalized anxiety disorder. J Headache Pain 12:331–338

    Article  PubMed  Google Scholar 

  12. Silberstein SD (2010) Association between restless legs syndrome and migraine. J Neurol Neurosurg Psychiatry 81:473–475

    Article  PubMed  Google Scholar 

  13. Suzuki S, Suzuki K, Miyamoto M, Miyamoto T, Watanabe Y, Takashima R, Hirata K (2011) Evaluation of contributing factors to restless legs syndrome in migraine patients. J Neurol 258:2026–2035

    Article  PubMed  Google Scholar 

  14. d’Onofrio F, Cologno D, Petretta V, Finocchi C, Autunno M, Marsala G, Usai S, Grazzi L, Omboni S, Fofi L, Barbanti P, Bussone G (2011) Restless legs syndrome is not associated with migraine with aura: a clinical study. Neurol Sci 32(Suppl 1):S153–S156

    Article  PubMed  Google Scholar 

  15. Sancisi E, Cevoli S, Vignatelli L, Nicodemo M, Pierangeli G, Zanigni S, Grimaldi D, Cortelli P, Montagna P (2010) Increased prevalence of sleep disorders in chronic headache: a case–control study. Headache 50(9):1464–1472

    Article  PubMed  Google Scholar 

  16. Brodtkorb E, Bakken IJ, Sjaastad O (2008) Comorbidity of migraine and epilepsy in a Norwegian community. Eur J Neurol 15:1421–1423

    Article  PubMed  CAS  Google Scholar 

  17. Ottman R, Lipton RB, Ettinger AB, Cramer JA, Reed ML, Morrison A, Wan GJ (2011) Comorbidities of epilepsy: results from the Epilepsy Comorbidities and Health (EPIC) survey. Epilepsia 52(2):308–315

    PubMed  Google Scholar 

  18. Schwedt T (2009) The migraine association with cardiac anomalies, cardiovascular disease and stroke. Neurol Clin 27(2):513–523

    Article  PubMed  Google Scholar 

  19. Kurth T (2010) The association of migraine with ischemic stroke. Curr Neurol Neurosci Rep 10:133–139

    Article  PubMed  Google Scholar 

  20. Bigal ME (2011) Migraine and cardiovascular disease. Arq Neuropsiquiatr 69(1):122–129

    PubMed  Google Scholar 

  21. Rist PM, Tzourio C, Kurth T (2011) Association between lipid levels and migraine: cross-sectional analysis in the Epidemiology of Vascular Ageing Study. Cephalalgia 31:1459–1465

    Article  PubMed  Google Scholar 

  22. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 339:b3914–b3925

    Article  PubMed  Google Scholar 

  23. Kurth T, Chabriat H, Bousser MG (2012) Migraine and stroke: a complex association with clinical implications. Lancet Neurol 11:92–100

    Article  PubMed  Google Scholar 

  24. Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB (2010) Migraine and cardiovascular disease. Neurology 74:628–635

    Article  PubMed  CAS  Google Scholar 

  25. Evans RW, de Tommaso M (2011) Migraine and fibromyalgia. Headache 51:195–299

    Google Scholar 

  26. Ravindran MK, Zheng Y, Timbol C, Merck SJ, Baraniuk JN (2011) Migraine headaches in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies. BMC Neurol 11:30–39

    Article  PubMed  Google Scholar 

  27. Riedl A, Schmidtmann M, Stengel A, Goebel M, Wisser AS, Klapp BF, Monnikes H (2008) Somatic comorbidities of irritable bowel syndrome: a systematic analysis. J Psychosom Res 64:573–582

    Article  PubMed  Google Scholar 

  28. Tjensvoll AB, Harboe E, Gøransson LG, Beyer MK, Greve OJ, Herigstad A, Kvaløy JT, Omdal R (2011) Migraine is frequent in patients with systemic lupus erythematosus: a case–control study. Cephalalgia 31:401–408

    Article  PubMed  Google Scholar 

  29. Katsiari CG, Vikelis M, Paraskevopoulou ES, Sfikakis PP, Mitsikostas DD (2011) Headache in systemic lupus erythematosus vs. multiple sclerosis: a prospective comparative study. Headache 51:1398–1407

    Article  PubMed  Google Scholar 

  30. Lessa B, Santana A, Lima I, Almeida JM, Santiago M (2006) Prevalence and classification of headache in patients with systemic lupus erythematosus. Clin Rheumatol 25:850–853

    Article  PubMed  Google Scholar 

  31. Tietjen GE, Bushnell CD, Herial NA, Utley C, White L, Hafeez F (2007) Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache 47:1069–1078

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors certify that there is no actual or potential conflict of interest in relation to this article.

Author information

Authors and Affiliations

  1. IRCCS Institute of Neurological Sciences, Bologna, Italy

    G. Giannini, S. Cevoli, L. Sambati & P. Cortelli

  2. Department of Neurological Sciences, Alma Mater Studiorum, University of Bologna, Via U. Foscolo 7, 40123, Bologna, Italy

    G. Giannini, S. Cevoli, L. Sambati & P. Cortelli

Authors
  1. G. Giannini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Cevoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Sambati
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Cortelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Cortelli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giannini, G., Cevoli, S., Sambati, L. et al. Migraine: risk factor and comorbidity. Neurol Sci 33 (Suppl 1), 37–41 (2012). https://doi.org/10.1007/s10072-012-1029-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-012-1029-6

Keywords

Search

Navigation