Effects of long-term electromagnetic field exposure on spatial learning and memory in rats
- 709 Downloads
With the development of communications industry, mobile phone plays an important role in daily life. Whether or not the electromagnetic radiation emitted by mobile phone causes any adverse effects on brain function has become of a great concern. This paper investigated the effect of electromagnetic field on spatial learning and memory in rats. 32 trained Wistar rats were divided into two groups: exposure group and control group. The exposure group was exposed to 916 MHz, 10w/m2 mobile phone electromagnetic field (EMF) 6 h a day, 5 days a week, 10 weeks. The completion time, number of total errors and the neuron discharge signals were recorded while the rats were searching for food in an eight-arm radial maze at every weekend. The neuron signals of one exposed rat and one control rat in the maze were obtained by the implanted microelectrode arrays in their hippocampal regions. It can be seen that during the weeks 4–5 of the experiment, the average completion time and error rate of the exposure group were longer and larger than that of control group (p < 0.05). During the weeks 1–3 and 6–9, they were close to each other. The hippocampal neurons showed irregular firing patterns and more spikes with shorter interspike interval during the whole experiment period. It indicates that the 916 MHz EMF influence learning and memory in rats to some extent in a period during exposure, and the rats can adapt to long-term EMF exposure.
KeywordsElectromagnetic field Wistar rats Eight-arm radial maze Hippocampal neuron
We would like to thank Mr. Nicolas Moncel from Ecole Centrale d’Electronique (ECE) Paris for its revision. This work was funded by the National Basic Research Program of China (973 Program), No. 2011CB503700/2011CB503702, the National Natural Science Foundation of China, No. 81071231 and 30670543, Research Program of Beijing Municipal Education Commission, No.KM200910005016 and Fundamental Research Fund for the Beijing Municipal Education Commission Science and Technology Innovation Platform No. JX015999201001.
Conflicts of interest
- 22.Jadidi M, Firoozabadi SM, Rashidy-Pour A et al (2009) Does whole body exposure to GSM-950 MHz electromagnetic fields affect acquisition and consolidation of spatial information in rats? Iran J Radiat Res 7(1):57–62Google Scholar
- 26.Arendash GW, Sanchez-Ramos J, Mori T et al (2010) Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer’s disease mice. J Alzheimer’s Dis 19:191–210Google Scholar
- 27.Dragicevic N, Bradshaw PC, Mamcarz M et al (2011) Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer’s transgenic mice and normal mice: a mechanism for electromagnetic field-induced cognitive benefit? Neuroscience 185:135–149PubMedCrossRefGoogle Scholar
- 30.Klur S, Muller C, Pereira de Vasconcelos A, Ballard T, Lopez J, Galani R, Certa U, Cassel JC (2009) Hippocampal-dependent spatial memory functions might be lateralized in rats: an approach combining gene expression profiling and reversible inactivation. HIPPOCAMPUS. 19:800–816PubMedCrossRefGoogle Scholar