Abstract
Reelin is a glycoprotein that acts as a stop signal for neuronal migration during brain ontogenesis. It plays an important role in the remodeling of the hippocampal formation and in stabilizing cortical architecture. We studied immunohistochemically 30 cases of focal cortical dysplasia (FCD) type IIIa to verify whether Reelin could represent the pathogenetic link between HS and cortical dyslamination in the setting of FCD type IIIa. Our results suggest that a subset of FCD type IIIa (namely abnormal cortical layering associated with MTS and GCD type 2) exists in which loss of Reelin appears to be the common pathogenetic basis. On the contrary in the other cases the presence of a common pathogenetic link remains to be demonstrated.
References
Campo CG, Sinagra M, Verrier D, Manzoni OJ, Chavis P (2009) Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis. PLoS One 4:e5505
Heinrich C, Nitta N, Flubacher A, Muller M, Fahrner A, Kirsch M, Freiman T, Suzuki F, Depaulis A, Frotscher M, Haas CA (2006) Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. J Neurosci 26:4701–4713
Frotscher M (2010) Role for Reelin in stabilizing cortical architecture. Trends Neurosci 33:407–414
Blümcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross H, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Ozkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R (2011) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc task force of the ILAE Diagnostic Methods Commission. Epilepsia 52:158–174
Palmini A, Najm I, Avanzino G, Babb T, Guerrini R, Foldvary-Schaefer N, Jackson G, Lüders HO, Prayson R, Spreafico R, Vinters HV (2004) Terminology and classification of the cortical dysplasias. Neurology 62:S2–S8
Blümcke I, Pauli E, Clusmann H, Schramm J, Becker A, Elger C, Merschhemke M, Meencke HJ, Lehmann T, von Deimling A, Scheiwe C, Zentner J, Volk B, Romstöck J, Stefan H, Hildebrandt M (2007) A new clinico-pathological classification system for mesial temporal sclerosis. Acta Neuropathol 113:235–244
Blümcke I, Kistner I, Clusmann H, Schramm J, Becker AJ, Elger CE, Bien CG, Merschhemke M, Meencke HJ, Lehmann T, Buchfelder M, Weigel D, Buslei R, Stefan H, Pauli E, Hildebrandt M (2009) Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies. Acta Neuropathol 117:535–544
Srikandarajah N, Martinian L, Sisodiya SM, Squier W, Blumcke I, Aronica E, Thom M (2009) Doublecortin expression in focal cortical dysplasia in epilepsy. Epilepsia 50:2619–2628
Conflict of interest
None of the authors has any conflict of interest to disclose.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Marucci, G., Farnedi, A. & Giulioni, M. Reelin: a possible link between hippocampal sclerosis and cortical dyslamination in the setting of FCD type IIIa. Neurol Sci 33, 1479–1481 (2012). https://doi.org/10.1007/s10072-011-0895-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-011-0895-7