Neurological Sciences

, Volume 32, Issue 4, pp 707–709 | Cite as

Pathological gambling plus hypersexuality in restless legs syndrome: a new case

  • Giuseppe d’Orsi
  • Vincenzo Demaio
  • L. M. Specchio
Case Report


Emerging clinical data indicate that dopaminergic agonists used to treat restless legs syndrome may be associated with dopamine dysregulation syndrome, particularly pathological gambling. We report a new case with pathological gambling plus hypersexuality and impotence in an old patient treated with a small dose (0.18 mg daily at bedtime) of pramipexole for restless legs syndrome for 5 months. The time relationship and the resolution upon discontinuation of dopaminergic agonists suggest a causative association. Our new case confirms that restless legs syndrome patients should be cautioned about potential dopamine dysregulation syndrome coinciding with dopaminergic agonists, as it can be reversed by drug withdrawal.


Pathological gambling Dopamine dysregulation syndrome Dopaminergic agonists Restless legs syndrome Parkinson’s disease Pramipexole 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Giuseppe d’Orsi
    • 1
  • Vincenzo Demaio
    • 2
  • L. M. Specchio
    • 1
  1. 1.Department of Neurological Sciences, Neurological Unit, Epilepsy Center, Riuniti HospitalClinic of Nervous System Diseases University of FoggiaFoggiaItaly
  2. 2.EEG LaboratoryOpera Don UvaBisceglieItaly

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