Neurological Sciences

, Volume 32, Supplement 1, pp 153–156 | Cite as

Restless legs syndrome is not associated with migraine with aura: a clinical study

  • F. d’Onofrio
  • D. Cologno
  • V. Petretta
  • C. Finocchi
  • M. Autunno
  • G. Marsala
  • S. Usai
  • L. Grazzi
  • S. Omboni
  • L. Fofi
  • P. Barbanti
  • G. Bussone
Brief Communication

Abstract

Based on recent data about the association between restless legs syndrome (RLS) and migraine, we performed an observational study on the occurrence of RLS in patients affected by “pure” migraine with aura (pMA). We recruited 63 patients (33 females and 30 males) affected by MA without other types of primary headache among all patients referred in five Italian headache centers in a 1-year period. The prevalence of RLS in pMA patients (9.5%) is similar to that observed in Italian headache-free subjects (8.3%). No significant differences were found between pMA patients with and without RLS about clinical features of MA attacks and systemic and psychiatric diseases were investigated. Moreover, no association appeared between RLS and familial cases of MA. Differently from migraine without aura, our data do not confirm the existence of an association between RLS and MA, not even when a genetic factor is involved.

Keywords

Migraine with aura Restless legs syndrome Association Clinical 

References

  1. 1.
    Rhode AM, Hösing VG, Happe S, Biehl K, Young P, Evers S et al (2007) Comorbidity of migraine and restless legs syndrome—a case-control study. Cephalalgia 27:1255–1260PubMedCrossRefGoogle Scholar
  2. 2.
    Chen PK, Fuh JL, Chen SP, Wang SJ (2010) Association between restless legs syndrome and migraine. J Neurol Neurosurg Psychiatry 81(5):524–528PubMedCrossRefGoogle Scholar
  3. 3.
    d’Onofrio F, Bussone G, Cologno D, Petretta V, Buzzi MG, Tedeschi G, Bonavita V, Cicarelli G (2008) Restless legs syndrome and primary headaches: a clinical study. Neurol Sci 29(Suppl 1):S169–S172PubMedCrossRefGoogle Scholar
  4. 4.
    Cologno D, Cicarelli G, Petretta V, d’Onofrio F, Bussone G (2008) High prevalence of dopaminergic premonitory symptoms in migraine patients with restless legs syndrome: a pathogenetic link? Neurol Sci 29(Suppl 1):S166–S168PubMedCrossRefGoogle Scholar
  5. 5.
    d’Onofrio F, Cologno D, Cicarelli G, Petretta V, Marsala G, Tullo V, Mea E, Casucci G, Bussone G (2011). Cluster headache patients are not affected by restless legs syndrome: an observational study. Clin Neurol Neurosurg. doi:10.1016/j.clineuro.2010.12.006 [in press].
  6. 6.
    Headache Classification Subcommittee of the International Headache Society (2004) The international classification of headache disorders. Cephalalgia 24(Suppl 1):9–160Google Scholar
  7. 7.
    Allen RP, Hening WA, Montplaisir J, Picchietti D, Trenkwalder C, Walters AS et al (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101–119PubMedCrossRefGoogle Scholar
  8. 8.
    American Academy of Sleep Medicine (2005) International classification of sleep disorders: diagnostic and coding manual, 2nd edn. American Academy of Sleep Medicine, WestchesterGoogle Scholar
  9. 9.
    Hamilton M (1959) The assessment of anxiety states by rating. Brit J Med Psychol 32:50PubMedGoogle Scholar
  10. 10.
    Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56PubMedCrossRefGoogle Scholar
  11. 11.
    Larner AJ (2007) Migraine with aura and restless legs syndrome. J Headache Pain 8:141–142PubMedCrossRefGoogle Scholar
  12. 12.
    Tartarotti S, Kallweit U, Bassetti CL (2010) Association of restless legs syndrome, chronic motion tics disease and migraine with aura: a case of a single family. J Neurol 257(6):1043–1044PubMedCrossRefGoogle Scholar
  13. 13.
    Bjorvatn B, Leissner L, Ulfberg J et al (2005) Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries. Sleep Med 6:307–312PubMedCrossRefGoogle Scholar
  14. 14.
    Sevim S, Dogu O, Kaleagasi H et al (2004) Correlation of anxiety and depression symptoms in patients with restless legs syndrome: a population based survey. J Neurol Neurosurg Psychiatry 75:226–230PubMedGoogle Scholar
  15. 15.
    Ulfberg J, Nystrom B, Carter N, Edling C (2001) Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 16:1159–1163PubMedCrossRefGoogle Scholar
  16. 16.
    Phillips B, Young T, Finn L et al (2000) Epidemiology of restless legs symptoms in adults. Arch Intern Med 160:2137–2141PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • F. d’Onofrio
    • 1
  • D. Cologno
    • 2
  • V. Petretta
    • 1
  • C. Finocchi
    • 3
  • M. Autunno
    • 4
  • G. Marsala
    • 2
  • S. Usai
    • 5
  • L. Grazzi
    • 5
  • S. Omboni
    • 6
  • L. Fofi
    • 7
  • P. Barbanti
    • 7
  • G. Bussone
    • 5
  1. 1.Neurology Unit, Headache Center“S. G. Moscati”AvellinoItaly
  2. 2.Department of NeuroscienceInstitute of Clinical Neurophysiology, Azienda Ospedaliera Universitaria “Ospedali Riuniti”FoggiaItaly
  3. 3.Department of Neuroscience, Ophthalmology and Genetics, Headache CenterUniversity of GenovaGenovaItaly
  4. 4.Department of Neuroscience, Psychiatric and Anesthesiologic Sciences, Neurology and Neuromuscle Diseases UnitAzienda Ospedaliera Universitaria Policlinico “G. Martino”MessinaItaly
  5. 5.Foundation IRCCS Neurological Institute C. BestaMilanItaly
  6. 6.Italian Institute of TelemedicineVareseItaly
  7. 7.Unit for Care and Research of Headaches and PainIRCCS “S. Raffaele Pisana”RomeItaly

Personalised recommendations