Abstract
Ewing’s sarcoma is a highly malignant neoplasm of bones which accounts for the 10% of primary bone malignancies. Primary Ewing’s sarcoma of skull vault is very rare and constitutes 1–6% of all Ewing’s sarcomas. We present a case of a primary and a radiation-induced skull Ewing’s sarcoma. The symptoms, neuroimaging findings and the treatment for these cases are reviewed. Both children were operated with favorable outcome.
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Hadfield MG, Quezado MM, Williams RL et al (2000) Ewing’s family of tumours involving structures related to the central nervous system: a review. Pediatr Dev Pathol 3:203–210
Bhansali SK, Desai PB (1963) Ewing’s sarcoma. Observations on 107 cases. J Bone Joint Surg [Am] 45:541–553
Moschovi M, Trimis G, Stefanaki K et al (2005) Favorable outcome of Ewing sarcoma family tumors to multiagent intensive preoperative chemotherapy: a single institution experience. J Surg Oncol 89:239–243
Ewing J (1972) Classics in oncology. Diffuse endothelioma of bone. James Ewing. Proceedings of the New York Pathological Society, 1921. CA Cancer J Clin 22:95–98
Pfeiffer J, Boedeker CC, Ridder GJ (2006) Primary Ewing sarcoma of the petrous temporal bone: an exceptional cause of facial palsy and deafness in a nursling. Head Neck 28:955–959
Fitzer PM, Steffey WR (1976) Brain and bone scans in primary Ewing’s sarcoma of the petrous bone. J Neurosurg 44:608–612
Desai KI, Nadkarni TD, Goel AH et al (2000) Primary Ewing’s sarcoma of the cranium. Neurosurgery 46:62–68
Kimball Dalton VM, Gelber RD, Li F et al (1998) Second malignancies in patients treated for childhood acute lymphoblastic leukemia. J Clin Oncol 16:2848–2853
Walter AW, Hancock ML, Pui CH et al (1998) Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children’s Research Hospital. J Clin Oncol 16:3761–3767
Hottinger AF, Khakoo Y (2009) Neurooncology of familial cancer syndromes. J Child Neurol 24:1526–1535
Sankaranarayanan K, Chakraborty R (2001) Impact of cancer predisposition and radiosensitivity on the population risk of radiation-induced cancers. Radiat Res 156:648–656
Utsuki S, Oka H, Sato K et al (2009) Radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater: a case report. Clin Neuropathol 28:96–100
Domenicucci M, Artico M, Nucci F et al (1990) Meningioma following high-dose radiation therapy. Case report and review of the literature. Clin Neurol Neurosurg 92:349–352
Cahan WG, Woodard HQ, Higinbotham NL et al (1998) Sarcoma arising in irradiated bone: report of eleven cases. 1948. Cancer 82:8–34
Li WY, Brock P, Saunders DE (2005) Imaging characteristics of primary cranial Ewing sarcoma. Pediatr Radiol 35:612–618
Ludwig JA (2008) Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol 20:412–418
Hayes FA, Thompson EI, Meyer WH et al (1989) Therapy for localized Ewing’s sarcoma of bone. J Clin Oncol 7:208–213
Grier HE, Krailo MD, Tarbell NJ et al (2003) Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 348:694–701
Sharma A, Garg A, Mishra NK et al (2005) Primary Ewing’s sarcoma of the sphenoid bone with unusual imaging features: a case report. Clin Neurol Neurosurg 107:528–531
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Moschovi, M., Alexiou, G.A., Tourkantoni, N. et al. Cranial Ewing’s sarcoma in children. Neurol Sci 32, 691–694 (2011). https://doi.org/10.1007/s10072-011-0509-4
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DOI: https://doi.org/10.1007/s10072-011-0509-4