Skip to main content
Log in

Long survival and clinical stability in Marburg’s variant multiple sclerosis

  • Case Report
  • Published:
Neurological Sciences Aims and scope Submit manuscript


Marburg’s variant multiple sclerosis (MS) is an acute and aggressive atypical form of MS, leading frequently to death in few months. A 32-year-old man with motor and sensory symptoms suggestive of acute myelopathy, rapidly followed by cerebellar dysfunction and consciousness impairment. Clinical, laboratory and radiological evaluations suggested a central nervous system demyelinating disease. The diagnosis was Marburg’s variant MS, usually leading to death in short time. He underwent different treatments, including steroids, cyclophosphamide, plasma exchange and lastly interferon-beta. The patient reached clinical stability with severe residual disability, persistent after 3 years from onset. This observation suggests that subjects with Marburg’s MS might reach long clinical stability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others


  1. Marburg O (1906) Die Sogennate “Acute Multiple Sclerosis” (encephalomyelitis pariaxialis scleroticans). Jahrl Psychiat Neurol 27:213–311

    Google Scholar 

  2. Krupp LB, Banwell B, Tenembaum S (2007) Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology 68(Suppl 2):S7–S12

    Article  PubMed  Google Scholar 

  3. Giubilei F, Sarrantonio A, Tisei P, Gasperini C, Salvetti M (1997) Four-year follow-up of a case of acute multiple sclerosis of the Marburg type. Ital J Neurol Sci 18:163–166

    Article  CAS  PubMed  Google Scholar 

  4. Jeffery DR, Lefkowitz DS, Crittenden JP (2004) Treatment of Marburg variant multiple sclerosis with mitoxantrone. J Neuroimaging 14:58–62

    PubMed  Google Scholar 

  5. Jasperson J, Jones AG (1998) A case of rapid deterioration: acute multiple sclerosis of the Marburg type. J Neurosci Nurs 30:350–351

    Article  CAS  PubMed  Google Scholar 

  6. Mendez MF, Pogacar S (1988) Malignant monophasic multiple sclerosis or “Marburg’s disease”. Neurology 38(7):1153–1155

    CAS  PubMed  Google Scholar 

  7. Johnson MD, Lavin P, Whetsell WO Jr (1990) Fulminant monophasic multiple sclerosis, Marburg’s type. J Neurol Neurosurg Psychiatry 53:918–921

    Article  CAS  PubMed  Google Scholar 

  8. Wood DD, Bilbao JM, O’Connors P (1996) Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein. Ann Neurol 40(1):18–24

    Article  CAS  PubMed  Google Scholar 

  9. Gonzàles Sàanchez J, Ensenyat Nora J, de Notaris M, Rumia Arboix J, Garcia-Amorena Garcia C, Ferrer Rodriguez E (2008) A case of malignant monophasic multiple sclerosis (Marburg’s disease type) successfully treated with decompressive hemicraniectomy. J Neurol Neurosurg Psychiatry

  10. Letournel F, Cassereau J, Scherer-Gagou C, Bernard I, Mercat A, Gray F et al (2008) An autopsy of acute multiple sclerosis (Marburg’s type) during pregnancy. Clin Neurol Neurosurg 110:514–517

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Marco Turatti.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Turatti, M., Gajofatto, A., Rossi, F. et al. Long survival and clinical stability in Marburg’s variant multiple sclerosis. Neurol Sci 31, 807–811 (2010).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: