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TNF-related apoptosis-inducing ligand level in Alzheimer’s disease

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Abstract

In the present study, we determined the significance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Alzheimer’s disease (AD). We characterized the expression of TRAIL protein in the cerebrospinal fluid (CSF) and serum with ELISA and TRAIL mRNA in the peripheral blood mononuclear cells (PBMCs) with real-time PCR in 22 patients with AD and 20 control cases. We could not find TRAIL protein in the CSF samples. The concentration of TRAIL protein in sera from patients with AD was not different from controls. However, there was an inverse correlation between serum TRAIL levels and Mini-Mental State Examination scores in AD patients. Also we did not find significant difference in TRAIL mRNA in the PBMCs of patients with AD when compared with control group. Our data indicate that TRAIL serum level decreases in the late stage of disease.

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Acknowledgments

We thank the patients and the relatives of the patients that have provided permission to obtain the samples. This study was funded by the Scientific and Technological Research Council of TURKEY (104S255). This research has been carried out at Dokuz Eylul University School of Medicine, Learning Resources Center, Research Laboratory (R-LAB).

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Authors and Affiliations

  1. Learning Resources Center Research Laboratory, School of Medicine, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey

    Sermin Genc, Mehtap Yuksel Egrilmez & Zahide Cavdar

  2. Department of Neurology, School of Medicine, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey

    Erdem Yaka & Gorsev Yener

  3. Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey

    Leyla Iyilikci

  4. Health and Science Institute, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey

    Kursad Genc

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  1. Sermin Genc
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  2. Mehtap Yuksel Egrilmez
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  3. Erdem Yaka
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  4. Zahide Cavdar
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  5. Leyla Iyilikci
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  6. Gorsev Yener
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  7. Kursad Genc
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Correspondence to Sermin Genc.

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Genc, S., Egrilmez, M.Y., Yaka, E. et al. TNF-related apoptosis-inducing ligand level in Alzheimer’s disease. Neurol Sci 30, 263–267 (2009). https://doi.org/10.1007/s10072-009-0047-5

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  • DOI: https://doi.org/10.1007/s10072-009-0047-5

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