Abstract
Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte®) has proven to be useful in clinical trials. We describe the case of a woman with a diagnosis of leptomeningeal carcinomatosis from breast carcinoma who presented cerebrospinal fluid normalization and prolonged complete MRI response to intrathecal chemotherapy with liposomal cytarabine (DepoCyte).
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References
Grossman SA, Krabak MJ (1999) Leptomeningeal carcinomatosis. Cancer Treat Rev 25(2):103–119
Pentheroudakis G, Pavlidis N (2005) Management of leptomeningeal malignancy. Expert Opin Pharmacother 6(7):1115–1125
Kim L, Glantz MJ (2001) Neoplastic meningitis. Curr Treat Options Oncol 2(6):517–527
Chamberlain MC (2006) Neoplastic meningitis. Neurologist 12(4):179–187
Glantz MJ, Walters BC (1998) Diagnosis and outcome measures in trials for neoplastic meningitis: a review of the literature and clinical experience. Neurosurg Focus 4(6):e4
Silvani A (2007) Experience with the intrathecal use of liposomal cytarabine at the Besta Institute. Tumori 93(3 Suppl):6–8
Glantz MJ, Jaeckle KA, Chamberlain MC, Phuphanich S, Recht L, Swinnen LJ et al (1999) A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res 5:3394–3402
Rueda Domínguez A, Olmos Hidalgo D, Viciana Garrido R, Torres Sánchez E (2005) Liposomal cytarabine (DepoCyte) for the treatment of neoplastic meningitis. Clin Transl Oncol 7(6):232–238
Esteva FJ, Soh LT, Holmes FA et al (2000) Phase II trial and pharmacokinetic evaluation of cytosine arabinoside for leptomeningeal metastases from breast cancer. Cancer Chemother Pharmacol 46:382–386
Jaeckle KA, Batchelor T, O’Day SJ, Phuphanich S, New P, Lesser G et al (2002) An open label trial of sustained-release cytarabine (DepoCyt™) for the intrathecal treatment of solid tumor neoplastic meningitis. J Neurooncol 7:231–239
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Gaviani, P., Silvani, A., Corsini, E. et al. Neoplastic meningitis from breast carcinoma with complete response to liposomal cytarabine: case report. Neurol Sci 30, 251–254 (2009). https://doi.org/10.1007/s10072-009-0044-8
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DOI: https://doi.org/10.1007/s10072-009-0044-8