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Clustering of organ-specific autoimmunity: a case presentation of multiple sclerosis and connective tissue disorders

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Abstract

Multiple sclerosis (MS) is the most common demyelinating disease caused by an autoimmune inflammatory process in the central nervous system (CNS) and is associated with aberrant immune response to myelin selfantigens. Coexistence of MS with other autoimmune disorders, including connective tissue disorders including systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome and scleroderma have been reported previously. In the present article we report the coexistence of MS, familial mediterranean fever and ankylosing spondylitis in a patient and review the clinical presentation, neurologic findings, cerebrospinal fluid and radiologic characteristics and treatment options. We further discuss the immunopathogenetic mechanisms for a possible association between MS and autoimmune disorders.

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Authors and Affiliations

  1. Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA

    Nilufer Kale

  2. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA

    Murat Icen

  3. Department of Neurology, Okmeydani Training and Teaching Hospital, Istanbul, Turkey

    Jale Agaoglu, Isil Yazici & Osman Tanik

Authors
  1. Nilufer Kale
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  2. Murat Icen
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  3. Jale Agaoglu
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  4. Isil Yazici
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  5. Osman Tanik
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Correspondence to Nilufer Kale.

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Kale, N., Icen, M., Agaoglu, J. et al. Clustering of organ-specific autoimmunity: a case presentation of multiple sclerosis and connective tissue disorders. Neurol Sci 29, 471–475 (2008). https://doi.org/10.1007/s10072-008-1015-1

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  • DOI: https://doi.org/10.1007/s10072-008-1015-1

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