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Cerebrovascular diseases

Neurological Sciences volume 29, pages 314–318 (2008)Cite this article

Abstract

Conventional neuroradiological techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI), make a fundamental contribution in both the acute and chronic phases of stroke. Recent years have witnessed the development of new imaging modalities, which include diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), CT-angiography (CTA), MR-angiography (MRA), magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and functional MRI (fMRI). While CTA, MRA, DWI and PWI are commonly used for clinical purposes, DTI, MRS and fMRI are becoming increasingly important in the field of experimental research of cerebrovascular diseases, but are still far from becoming of primary usefulness in the everyday clinical setting.

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References

  1. Brown MM, Markus H, Oppenheimer S (2006) Stroke medicine. Taylor & Francis: Oxon

    Google Scholar 

  2. Inoue Y, Takemoto K, Miyamoto T et al (1980) Sequential computed tomography scans in acute cerebral infarction. Radiology 135:655–662

    PubMed  CAS  Google Scholar 

  3. Bozzao L, Bastianello S, Fantozzi LM et al (1989) Correlation of angiographic and sequential CT findings in patients with evolving cerebral infarction. AJNR Am J Neuroradiol 10:1215–1222

    PubMed  CAS  Google Scholar 

  4. Hacke W, Kaste M, Fieschi C et al (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 274:1017–1025

    PubMed  Article  CAS  Google Scholar 

  5. Hill MD, Demchuk AM, Tomsick TA et al (2006) Using the baseline CT scan to select acute stroke patients for IV-IA therapy. AJNR Am J Neuroradiol 27:1612–1616

    PubMed  CAS  Google Scholar 

  6. Toni D, Fiorelli M, Bastianello S et al (1996) Hemorrhagic transformation of brain infarct: predictability in the first five hours from stroke onset and influence on clinical outcome. Neurology 46:341–345

    PubMed  CAS  Google Scholar 

  7. Bastianello S, Pierallini A, Colonnese C et al (1991) Hyperdense middle cerebral artery CT sign: comparison with angiography in the acute phase of ischemic supratentorial infarction. Neuroradiology 33:207–211

    PubMed  Article  CAS  Google Scholar 

  8. Pantano P, Caramia F, Bozzao L et al (1999) Delayed increase in infarct volume after cerebral ischemia: correlations with thrombolytic treatment and clinical outcome. Stroke 30:502–507

    PubMed  CAS  Google Scholar 

  9. Wintermark M, Reichhart M, Cuisenaire O et al (2002) Comparison of admission perfusion computed tomography and qualitative diffusion-and perfusion-weighted magnetic resonance imaging in acute stroke patients. Stroke 33:2025–2031

    PubMed  Article  CAS  Google Scholar 

  10. Warach S, Chien D, Li W et al (1992) Fast magnetic resonance diffusion-weighted imaging of acute human stroke. Neurology 42:1717–1723

    PubMed  CAS  Google Scholar 

  11. Lovblad KO, Laubach HJ, Baird AE et al (1998) Clinical experience with diffusion-weighted MR in patients with acute stroke. AJNR Am J Neuroradiol 19:1061–1066

    PubMed  CAS  Google Scholar 

  12. Baird AE, Benfield A, Schlaug G et al (1997) Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 41:581–589

    PubMed  Article  CAS  Google Scholar 

  13. Schlaug G, Siewert B, Benfield A et al (1997) Time course of apparent diffusion coefficient (ADC) abnormality in human stroke. Neurology 49:113–119

    PubMed  CAS  Google Scholar 

  14. Rosen BR, Belliveau JW, Vevea JM et al (1990) Perfusion imaging with NMR contrast agents. Magn Reson Med 14: 249–265

    PubMed  Article  CAS  Google Scholar 

  15. Barber PA, Darby DG, Desmond PM et al (1999) Identification of major ischemic change. Diffusion-weighted imaging versus computed tomography. Stroke 30:2059–2065

    CAS  Google Scholar 

  16. Hjort N, Butcher K, Davis SM et al (2005) UCLA Thrombolysis Investigators. Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct. Stroke 36:388–397

    PubMed  Article  CAS  Google Scholar 

  17. Wintermark M, Albers GW, Alexandrov AV et al (2008) Acute stroke imaging research roadmap. AJNR Am J Neuroradiol 29:e23–e30

    PubMed  Article  Google Scholar 

  18. Parsons MW, Yang Q, Barber PA et al (2001) Perfusion magnetic resonance imaging maps in hyperacute stroke: relative cerebral blood flow most accurately identifies tissue destined to infarct. Stroke 32: 1581–1587

    PubMed  CAS  Google Scholar 

  19. Kidwell CS, Saver JL, Mattiello J et al (2000) Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 47:462–469

    PubMed  Article  CAS  Google Scholar 

  20. Pantano P, Toni D, Caramia F et al (2001) Relationship between vascular enhancement, cerebral hemodynamics and MR angiography in acute stroke patients. AJNR Am J Neuroradiology 22:255–260

    CAS  Google Scholar 

  21. Chollet F, DiPiero V, Wise RJ et al (1991) The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Ann Neurol 29:63–71

    PubMed  Article  CAS  Google Scholar 

  22. Cramer SC, Nelles G, Benson RR et al (1997) A functional MRI study of subjects recovered from hemiparetic stroke. Stroke 28:2518–2527

    PubMed  CAS  Google Scholar 

  23. Cao Y, D’Olhaberriague L, Vikingstad EM (1998) Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. Stroke 29:112–122

    PubMed  CAS  Google Scholar 

  24. Feydy A, Carlier R, Roby-Brami A et al (2002) Longitudinal study of motor recovery after stroke: recruitment and focusing of brain activation. Stroke 33:1610–1617

    PubMed  Article  CAS  Google Scholar 

  25. Ward NS, Broen MM, Thompson AJ et al (2003) Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 126:2476–2496

    PubMed  Article  CAS  Google Scholar 

  26. Richards LG, Stewart KC, Woodbury ML et al (2008) Movement-dependent stroke recovery: a systematic review and meta-analysis of TMS and fMRI evidence. Neuropsychologia 46:3–11

    PubMed  Article  Google Scholar 

  27. Pariente J, Loubinoux I, Carel C et al (2001) Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol 50:718–729

    PubMed  Article  CAS  Google Scholar 

  28. Mori S, Zhang J (2006) Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 51:527–539

    PubMed  Article  CAS  Google Scholar 

  29. Thomalla G, Glauche V, Koch MA et al (2004) Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke. Neuroimage 22:1767–1774

    PubMed  Article  Google Scholar 

  30. Liang Z, Zeng J, Liu S et al (2007) A prospective study of secondary degeneration following subcortical infarction using diffusion tensor imaging. J Neurol Neurosurg Psychiatry 78:581–586

    PubMed  Article  Google Scholar 

  31. Møller M, Frandsen J, Andersen G et al (2007) Dynamic changes in corticospinal tracts after stroke detected by fibretracking. J Neurol Neurosurg Psychiatry 78:587–592

    PubMed  Article  Google Scholar 

  32. Liang Z, Zeng J, Zhang C et al (2008) Longitudinal investigations on the anterograde and retrograde degeneration in the pyramidal tract following pontine infarction with diffusion tensor imaging. Cerebrovasc Dis 25:209–216

    PubMed  Article  Google Scholar 

  33. Gideon P, Henriksen O, Sperling B et al (1992) Early time course of N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline in the brain after acute stroke. A proton magnetic resonance spectroscopy study. Stroke 23:1566–1572

    PubMed  CAS  Google Scholar 

  34. Rothman DL, Howseman AM, Graham GD et al (1991) Localized proton NMR observation of [3–13C] lactate in stroke after [1–13C] glucose infusion. Magn Reson Med 21:302–307

    PubMed  Article  CAS  Google Scholar 

  35. Gillard JH, Barker PB, van Zijl PC et al (1996) Proton MR spectroscopy in acute middle cerebral artery stroke. AJNR Am J Neuroradiol 17:873–886

    PubMed  CAS  Google Scholar 

  36. Pereira AC, Saunders DE, Doyle VL et al (1999) Measurement of initial N-acetyl aspartate concentration by magnetic resonance spectroscopy and initial infarct volume by MRI predicts outcome in patients with middle cerebral artery territory infarction. Stroke 30:1577–1582

    PubMed  CAS  Google Scholar 

  37. Parsons MW, Li T, Barber PA et al (2000) Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome. Neurology 55:498–505

    PubMed  CAS  Google Scholar 

  38. Nicoli F, Lefur Y, Denis B et al (2003) Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study. Stroke 34:82–87

    Article  Google Scholar 

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Affiliations

  1. Department of Neurological Sciences, Viale dell’ Università, 30, 00185, Rome, Italy

    Patrizia Pantano, Porzia Totaro & Eytan Raz

Authors
  1. Patrizia Pantano
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  2. Porzia Totaro
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  3. Eytan Raz
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Correspondence to Patrizia Pantano.

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Pantano, P., Totaro, P. & Raz, E. Cerebrovascular diseases. Neurol Sci 29, 314–318 (2008). https://doi.org/10.1007/s10072-008-1006-2

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  • DOI: https://doi.org/10.1007/s10072-008-1006-2

Keywords

  • Stroke
  • Computed tomography (CT)
  • Magnetic resonance imaging (MRI)
  • Functional magnetic resonance imaging (fMRI)
  • Magnetic resonance spectroscopy (MRS)
  • Diffusion tensor imaging (DTI)