Skip to main content
SpringerLink
Log in

Fatal cerebral haemorrhage after liver transplantation in a patient with transthyretin variant (gly53glu) amyloidosis

  • CASE REPORT
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Transthyretin (TTR) amyloidosis is a form of systemic amyloidosis caused by an amyloidogenetic TTR variant. The most common mutant forms of TTR are mainly produced by the liver and therefore orthotopic liver transplantation (OLT) is currently accepted as the only known curative treatment. We describe the clinical and pathological features of a patient with TTR variant (gly53glu) with TTR amyloid infiltration of the leptomeningeal vessels in whom fatal cerebral haemorrhage occurred two months after OLT, soon after severe viral pneumonia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Unità Operativa di Neurologia, Ospedale di Lugo, Viale Dante 10, I-48022, Lugo (RA), Italy

    P. De Carolis & M. Galeotti

  2. Dipartimento Sevizi Diagnostici di Laboratorio e di Medicina, Legale Anatomia Patologica, Policlinico di Modena, Modena, Italy

    G. Ficarra

  3. Dipartimento di Chirurgia Generale e Specialità Chirurgiche, Policlinico di Modena, Università di Modena e Reggio Emilia Modena, Modena, Italy

    M. Masetti

  4. Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy

    D. Grimaldi &  P. Cortelli

Authors
  1. P. De Carolis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Galeotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Ficarra
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Masetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Grimaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Cortelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. De Carolis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

De Carolis, P., Galeotti, M., Ficarra, G. et al. Fatal cerebral haemorrhage after liver transplantation in a patient with transthyretin variant (gly53glu) amyloidosis. Neurol Sci 27, 352–354 (2006). https://doi.org/10.1007/s10072-006-0709-5

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-006-0709-5

Key words

Search

Navigation