Skip to main content
SpringerLink
Log in

Busulfan neurotoxicity and EEG abnormalities: a case report

  • CASE REPORT
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract.

A 21-year-old woman with acute lymphoblastic leukemia underwent bone marrow transplantation (BMT). The conditioning regimen consisted of an association of busulfan (BU) and cyclophosphamide (Cy). The day after starting BU, she suffered a generalized tonic-clonic seizure. Electroencephalography (EEG) performed the day after the seizure showed diffuse polyspikes and spike-and-wave discharges. EEG on the following days showed persistent abnormalities (slowing of background activity intermixed with diffuse slow waves and isolated delta and theta bursts). These abnormalities persisted for about 20 days with complete normalization one month after the seizure. We suggest that BU is implicated in these abnormalities and emphasize the importance of EEG recording before and after bone marrow transplantation to disclose BU neurotoxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Neurology Unit, S. Orsola-Malpighi Hospital, University of Bologna, Via Albertoni 15, I-40138, Bologna, Italy

    C. La Morgia, S. Mondini, M. Guarino & F. Cirignotta

  2. Institute of Hematology, University of Bologna, Bologna, Italy

    F. Bonifazi

Authors
  1. C. La Morgia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Mondini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Guarino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Bonifazi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Cirignotta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. La Morgia.

Rights and permissions

Reprints and permissions

About this article

Cite this article

La Morgia, C., Mondini, S., Guarino, M. et al. Busulfan neurotoxicity and EEG abnormalities: a case report. Neurol Sci 25, 95–97 (2004). https://doi.org/10.1007/s10072-004-0237-0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-004-0237-0

Key words

Search

Navigation