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Effects of NET-2201 (Capsicum chinense L. cv.) on brown adipose tissue activation and white adipose tissue browning in high-fat-diet-induced obese mice

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Abstract

The present study explored the anti-obesity effects of NET-2201 (Capsicum chinense L. cv.), a non-pungent cultivated variety of chili pepper, and its underlying molecular mechanism in high-fat-diet (HFD)-induced obese mice. Administration of 50 mg/kg NET-2201 significantly inhibited body weight (BW) gain and reduced adipose tissue weight in obese mice. NET-2201 caused improvement in the expression levels of genes associated with lipid metabolism in white adipose tissue (WAT) to near-normal levels. Furthermore, NET-2201 significantly increased peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and uncoupling protein 1 (UCP1) protein expressions in brown adipose tissue (BAT). Moreover, NET-2201 activated WAT browning by altering the expression levels of brown and beige adipocyte-selective genes, including UCP1, PGC-1α, and PR domain containing 16. Our results indicate that dietary NET-2201 mitigates BW gain by activating BAT and inducing WAT browning.

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Acknowledgements

This research was carried out without financial assistance from any public, commercial, or non-profit funding sources.

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Authors and Affiliations

  1. Herbal Hormone Research Institute, Naturalendo Tech Co., Ltd, Seongnam, 13486, Republic of Korea

    Yoon-Young Han, Ha-Neul Jo, Bo-Mi Kim, Jae-Sun Lee, Ji-Min Kim, Dae-Ho Ryu, Dong-Hee Kim, Chan-Sung Park & Yong-Wook Lee

  2. Department of Plant Science and Plant Genomics and Breeding Institute, Seoul National University, Seoul, 151-921, Republic of Korea

    Byoung-Cheorl Kang

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  1. Yoon-Young Han
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Han, YY., Jo, HN., Kim, BM. et al. Effects of NET-2201 (Capsicum chinense L. cv.) on brown adipose tissue activation and white adipose tissue browning in high-fat-diet-induced obese mice. Food Sci Biotechnol (2024). https://doi.org/10.1007/s10068-024-01692-z

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