Skip to main content
Log in

Effect of MIND diet on cognitive function in elderly: a narrative review with emphasis on bioactive food ingredients

  • Invited Review
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

As the world becomes a super-aged society, cognitive decline is public health problems that are increasing rapidly. A healthy diet has great potential for maintaining cognitive health. A diet that could delay the onset of neurodegenerative diseases has been developed: the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, a hybrid form of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. In this review, the effects of the MIND diet on improving cognitive function, including memory, are summarized. In most studies, the higher the adherence to the MIND diet, the higher the cognitive function evaluation score, and the lower the incidence of dementia. This is because of the anti-inflammatory and antioxidant effects of the major nutritional components of the MIND diet: folate, carotenoids, polyphenols, and polyunsaturated fatty acids. Adherence to the MIND diet, containing various bioactive food ingredients, is related to cognitive improvement in the elderly population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi T, Azizi F. Beneficial effects of a dietary approaches to stop hypertension eating plan on features of the metabolic syndrome. Diabetes Care. 28: 2823-2831 (2005)

    CAS  PubMed  Google Scholar 

  • Baddeley A. Working memory. Science. 255: 556-559 (1992)

    CAS  PubMed  Google Scholar 

  • Barbalho SM, Direito R, Laurindo LF, Marton LT, Guiguer EL, Goulart RA, Tofano RJ, Carvalho ACA, Flato UAP, Capelluppi Tofano VA, Detregiachi CRP, Bueno PCS, Girio RSJ, Araújo AC. Ginkgo biloba in the aging process: A narrative review. Antioxidants. 11: 525 (2022)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Berendsen AA, Kang JH, van de Rest O, Feskens EJ, de Groot LC, Grodstein F. The dietary approaches to stop hypertension diet, cognitive function, and cognitive decline in American older women. Journal of the American Medical Directors Association. 18: 427-432 (2017)

    PubMed  Google Scholar 

  • Bo Y, Zhang X, Wang Y, You J, Cui H, Zhu Y, Pang W, Liu W, Jiang Y, Lu Q. The n-3 polyunsaturated fatty acids supplementation improved the cognitive function in the Chinese elderly with mild cognitive impairment: A double-blind randomized controlled trial. Nutrients. 9: 54 (2017)

    PubMed  PubMed Central  Google Scholar 

  • Calil SR, Brucki SM, Nitrini R, Yassuda MS. Adherence to the Mediterranean and MIND diets is associated with better cognition in healthy seniors but not in MCI or AD. Clinical Nutrition ESPEN. 28: 201-207 (2018)

    PubMed  Google Scholar 

  • Cena H, Calder PC. Defining a healthy diet: evidence for the role of contemporary dietary patterns in health and disease. Nutrients. 12: 334 (2020)

    PubMed  PubMed Central  Google Scholar 

  • Chauhan A, Chauhan V. Beneficial effects of walnuts on cognition and brain health. Nutrients. 12: 550 (2020)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen JH, Lin KP, Chen YC. Risk factors for dementia. Journal of the Formosan Medical Association. 108: 754-764 (2009)

    PubMed  Google Scholar 

  • de Crom TO, Mooldijk SS, Ikram MK, Ikram MA, Voortman T. MIND diet and the risk of dementia: A population-based study. Alzheimer's Research & Therapy. 14: 1-10 (2022)

    Google Scholar 

  • Elsayed MM, Rabiee A, El Refaye GE, Elsisi HF. Aerobic exercise with Mediterranean-DASH Intervention for Neurodegenerative Delay diet promotes brain cells’ longevity despite sex hormone deficiency in postmenopausal women: A randomized controlled trial. Oxidative Medicine and Cellular Longevity. (2022)

  • Furio AM, Brusco LI, Cardinali DP. Possible therapeutic value of melatonin in mild cognitive impairment: A retrospective study. Journal of Pineal Research. 43: 404-409 (2007)

    CAS  PubMed  Google Scholar 

  • Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B. Mild cognitive impairment. The Lancet. 367: 1262-1270 (2006)

    Google Scholar 

  • Huang X, Aihemaitijiang S, Ye C, Halimulati M, Wang R, Zhang Z. Development of the cMIND diet and its association with cognitive impairment in older Chinese people. The Journal of Nutrition, Health & Aging. 26: 760-770 (2022)

    CAS  Google Scholar 

  • Jeong EH, Kim E, Hong CH, Moon SY, Park HK, Jeong JH, Na HR, Choi SH, Park YK. Practicability of six weeks of Korean-style Mediterranean diet for elderly Koreans with high risk for dementia. Journal of the Korean Dietetic Association. 25: 237-256 (2019)

    Google Scholar 

  • Kang EY, Cui F, Kim HK, Go GW. Bioactive compounds in food for age-associated cognitive decline: A systematic review. Korean Journal of Food Science and Technology. 53: 278-289 (2021)

    Google Scholar 

  • Kang EY, Cui F, Kim HK, Nawaz H, Kang S, Kim H, Jang J, Go GW. Effect of phosphatidylserine on cognitive function in the elderly: A systematic review and meta-analysis. Korean Journal of Food Science and Technology. 54: 52-58 (2022)

    Google Scholar 

  • Kheirouri S, Alizadeh M. MIND diet and cognitive performance in older adults: a systematic review. Critical Reviews in Food Science and Nutrition. 1–19 (2021)

  • Kishida R, Yamagishi K, Maruyama K, Okada C, Tanaka M, Ikeda A, Hayama-Terada M, Shimizu Y, Muraki I, Umesawa M, Imano H, Brunner EJ, Sankai T, Okada T, Kitamura A, Kiyama M, Iso H. Dietary intake of beans and risk of disabling dementia: The circulatory risk in communities study (CIRCS). European Journal of Clinical Nutrition. 1–6 (2022)

  • Korean Dementia Observatory. Available from: https://www.nid.or.kr/ info/dataroom _ view.aspx?bid=243. Accessed Jun. 20, 2023.

  • Korte N, Nortley R, Attwell D. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease. Acta Neuropathologica. 140: 793-810 (2020)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lee DW, Seong SJ. Korean national dementia plans: from 1st to 3rd. Journal of the Korean Medical Association. 61: 298-303 (2018)

    Google Scholar 

  • Liu X, Morris MC, Dhana K, Ventrelle J, Johnson K, Bishop L, Hollings CS, Boulin A, Laranjo N, Stubbs BJ, Reilly X, Carey VJ, Wang Y, Furtado JD, Marcovina SM, Tangney C, Aggarwal NT, Arfanakis K, Sacks FM, Barnes LL. Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline. Contemporary clinical trials. 102: 106270 (2021)

    PubMed  PubMed Central  Google Scholar 

  • Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, Llewellyn DJ. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology. 479–489 (2013)

  • Ma F, Li Q, Zhou X, Zhao J, Song A, Li W, Liu H, Xu W, Huang G. Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: A randomized controlled trial. European Journal of Nutrition. 58: 345-356 (2019)

    CAS  PubMed  Google Scholar 

  • McEvoy CT, Guyer H, Langa KM, Yaffe K. Neuroprotective diets are associated with better cognitive function: the health and retirement study. Journal of the American Geriatrics Society. 65: 1857-1862 (2017)

    PubMed  PubMed Central  Google Scholar 

  • Mecocci P. Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. Journal of Alzheimer's Disease. 6: 159-163 (2004)

    CAS  Google Scholar 

  • Ministry of Health and Welfare. Status of dementia by city, county and district. Available from: https://www.data.go.kr/data/15073342/fileData.do Accessed Jun. 20, 2023.

  • Mohammadzadeh Honarvar N, Saedisomeolia A, Abdolahi M, Shayeganrad A, Taheri Sangsari G, Hassanzadeh Rad B, Muench G. Molecular anti-inflammatory mechanisms of retinoids and carotenoids in Alzheimer’s disease: a review of current evidence. Journal of Molecular Neuroscience. 61: 289–304 (2017)

    CAS  PubMed  Google Scholar 

  • Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT. MIND diet slows cognitive decline with aging. Alzheimer's and Dementia. 11: 1015-1022 (2015a)

    Google Scholar 

  • Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimer's and Dementia. 11: 1007-1014 (2015b)

    Google Scholar 

  • Morris MC, Wang Y, Barnes LL, Bennett DA, Dawson-Hughes B, Booth SL. Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study. Neurology. 90: e214-e222 (2018)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mufson EJ, Binder L, Counts SE, DeKosky ST, de Toledo-Morrell L, Ginsberg SD, Ikonomovic MD, Perez SE, Scheff SW. Mild cognitive impairment: pathology and mechanisms. Acta Neuropathologica. 123: 13-30 (2012)

    CAS  PubMed  Google Scholar 

  • Munoz-Garcia MI, Toledo E, Razquin C, Dominguez LJ, Maragarone D, Martinez-Gonzalez J, Martinez-Gonzalez MA. “A priori” dietary patterns and cognitive function in the SUN project. Neuroepidemiology. 54: 45-57 (2020)

    PubMed  Google Scholar 

  • Newman AB, Fitzpatrick AL, Lopez O, Jackson S, Lyketsos C, Jagust W, Ives D, Dekosky ST, Kuller LH. Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort. Journal of the American Geriatrics Society. 53: 1101-1107 (2005)

    PubMed  Google Scholar 

  • Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2-year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. The Lancet. 385: 2255-2263 (2015)

    Google Scholar 

  • Nishi SK, Babio N, Gómez-Martínez C, Martínez-González MÁ, Ros E, Corella D, Castañer O, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Martín Sánchez V, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Razquin C, Coltell O, Becerra-Tomás N, De La Torre Fornell R, Abete I, Sorto-Sanchez C, Barón-López FJ, Signes-Pastor AJ, Konieczna J, Garcia-Rios A, Casas R, Gomez-Perez AM, Santos-Lozano JM, García-Arellano A, Guillem-Saiz P, Ni J, Trinidad Soria-Florido M, Zulet MÁ, Vaquero-Luna J, Toledo E, Fitó M, Salas-Salvadó J. Mediterranean, DASH, and MIND dietary patterns and cognitive function: the 2-year longitudinal changes in an older Spanish cohort. Frontiers in Aging Neuroscience. 847 (2021)

  • Oh E, Lee AY. Mild cognitive impairment. Journal of the Korean Neurological Association. 34: 167-175 (2016)

    Google Scholar 

  • Petersen RC. Mild cognitive impairment. Continuum: Lifelong Learning in Neurology. 22(2 Dementia): 404 (2016)

  • Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Porcellini E, Licastro F. Homocysteine and folate as risk factors for dementia and Alzheimer disease. The American Journal of Clinical Nutrition. 82: 636-643 (2005)

    CAS  PubMed  Google Scholar 

  • Reale M, Costantini E, Jagarlapoodi S, Khan H, Belwal T, Cichelli A. Relationship of wine consumption with Alzheimer’s disease. Nutrients. 12: 206 (2020)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial. PLoS ONE. 5: e12244 (2010)

    PubMed  PubMed Central  Google Scholar 

  • Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh-Bohmer KA, Browndyke JN, Strauman TA, Sherwood A. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension. 55: 1331-1338 (2010)

    CAS  PubMed  Google Scholar 

  • Song J, Choi SH, Hong CH, Jeong JH, Moon SY, Na HR, Park HK, Park YK. The effect of the dementia prevention nutrition program using the MIND Diet on the changes in cognitive function of the elderly with high-dementia risks. Journal of the Korean Dietetic Association. 27: 248-262 (2021)

    Google Scholar 

  • Statistics Korea. 2021 Elderly statistics. Available from: https://eiec.kdi.re.kr/policy/ material View.do?num=230699&topic=. Accessed Jun. 20, 2023.

  • Su HM. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. The Journal of Nutritional Biochemistry. 21: 364-373 (2010)

    CAS  PubMed  Google Scholar 

  • Tangney CC. DASH and Mediterranean-type dietary patterns to maintain cognitive health. Current Nutrition Reports. 3: 51-61 (2014)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Thal DR, Rüb U, Orantes M, Braak H. Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology. 58: 1791-1800 (2002)

    PubMed  Google Scholar 

  • Thomas A, Lefevre-Arbogast S, Feart C, Foubert-Samier A, Helmer C, Catheline G, Samieri C. Association of a MIND Diet with brain structure and dementia in a French population. The Journal of Prevention of Alzheimer's Disease. 9: 655-664 (2022)

    CAS  PubMed  Google Scholar 

  • Tokuda H, Ito M, Sueyasu T, Sasaki H, Morita S, Kaneda Y, Rogi T, Kondo S, Kouzaki M, Tsukiura T, Shibata H. Effects of combining exercise with long-chain polyunsaturated fatty acid supplementation on cognitive function in the elderly: A randomised controlled trial. Scientific Reports. 10: 1-12 (2020)

    Google Scholar 

  • Vinciguerra F, Graziano M, Hagnäs M, Frittitta L, Tumminia A. Influence of the Mediterranean and ketogenic diets on cognitive status and decline: A narrative review. Nutrients. 12: 1019 (2020)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wajman JR, Mansur LL, Yassuda MS. Lifestyle patterns as a modifiable risk factor for late-life cognitive decline: A narrative review regarding dementia prevention. Current Aging Science. 11: 90-99 (2018)

    PubMed  Google Scholar 

  • Wesselman LMP, van Lent DM, Schröder A, van de Rest O, Peters O, Menne F, Fuentes M, Priller J, Spruth EJ, Altenstein S, Schneider A, Fließbach K, Roeske S, Wolfsgruber S, Kleineidam L, Spottke A, Pross V, Wiltfang J, Vukovich R, Schild AK, Düzel E, Metzger CD, Glanz W, Buerger K, Janowitz D, Perneczky R, Tatò M, Teipel S, Kilimann I, Laske C, Buchmann M, Ramirez A, Sikkes SAM, Jessen F, van der Flier WM, Wagner M. Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease. European Journal of Nutrition. 60: 849-860 (2021)

    CAS  PubMed  Google Scholar 

  • Williams RJ, Spencer JP. Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radicals in Biology and Medicine. 52: 35-45 (2012)

    CAS  Google Scholar 

  • World Health Organization. Fact sheet: ageing and health. Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health. Accessed Jun. 20, 2023.

  • Yeung SS, Kwan M, Woo J. Healthy diet for healthy aging. Nutrients. 13: 4310 (2021)

    PubMed  PubMed Central  Google Scholar 

  • Yuan C, Chen H, Wang Y, Schneider JA, Willett WC, Morris MC. Dietary carotenoids related to risk of incident Alzheimer dementia (AD) and brain AD neuropathology: a community-based cohort of older adults. The American Journal of Clinical Nutrition. 113: 200-208 (2021)

    PubMed  Google Scholar 

  • Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimer's and Dementia. 6: 456-464 (2010)

    CAS  Google Scholar 

  • Zhang X, Bao G, Liu D, Yang Y, Li X, Cai G, Liu Y, Wu Y. The association between folate and Alzheimer's disease: A systematic review and meta-analysis. Frontiers in Neuroscience. 385 (2021)

Download references

Acknowledgements

This research was supported by funding from the Ottogi Ham Taiho Foundation (Grant Number: 201900000670003).

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Sang Gill Lee or Gwang-woong Go.

Ethics declarations

Conflict of interest

The authors declare that there are no conflicts of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Seo, Y., Gang, G., Kim, H.K. et al. Effect of MIND diet on cognitive function in elderly: a narrative review with emphasis on bioactive food ingredients. Food Sci Biotechnol 33, 297–306 (2024). https://doi.org/10.1007/s10068-023-01465-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-023-01465-0

Keywords

Navigation