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A combined extract containing Schisandra chinensis (SCE) reduced hepatic triglyceride accumulation in rats fed a high-sucrose diet

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Abstract

Excessive hepatic lipid accumulation is closely linked to inflammation, insulin resistance, and metabolic syndromes. We hypothesized that a combined extract containing Schisandra chinensis (SCE) could alleviate hepatic lipid accumulation. Male Sprague–Dawley rats fed a high-sucrose diet (HSD) were randomly assigned to three groups (n = 6): normal diet (ND), HSD (60% kcal from sucrose), and HSD + SCE (HSD with 2.44% SCE). Liquid chromatography–tandem mass spectrometry revealed that SCE contains chlorogenic acid (5.514 ± 0.009 mg/g) and schisandrin (0.179 ± 0.002 mg/g) as bioactive components. SCE did not alter the body weight, fat mass, lean mass, or glucose levels. Strikingly, SCE effectively reduced the plasma triglyceride (TG) and hepatic TG levels compared to the HSD group. Adiposity reduction is due to decreased activity of hepatic de novo lipogenic enzymes. These results indicated that SCE has nutraceutical potential for the prevention and treatment of hepatic steatosis.

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  1. Haneul Lee, Eun Young Kang, and Joowon Lee have contributed equally to this work.

Authors and Affiliations

  1. Department of Food and Nutrition, Hanyang University, Seoul, 04763, Republic of Korea

    Haneul Lee, Eun Young Kang, Yejin Kim, Sumin Kang, Hayoon Kim, Hyun Kyung Kim & Gwang-woong Go

  2. Department of Food Science and Nutrition, Pukyong National University, Busan, 48513, Republic of Korea

    Joowon Lee, Gyoungok Gang & Sang-gil Lee

  3. Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University, Seongnam, Republic of Korea

    Cao Lei

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  1. Haneul Lee
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Lee, H., Kang, E.Y., Lee, J. et al. A combined extract containing Schisandra chinensis (SCE) reduced hepatic triglyceride accumulation in rats fed a high-sucrose diet. Food Sci Biotechnol 33, 1449–1457 (2024). https://doi.org/10.1007/s10068-023-01464-1

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