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Enhancement of the bioavailability of phenolic compounds from fruit and vegetable waste by liposomal nanocarriers

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Abstract

Fruits and vegetables are one of the most consumed and processed commodities globally and comprise abundant phenolic compounds, one of the main nutraceuticals in the food industry. Comparably elevated rates of these compounds are found in waste (peel, seeds, leaf, stem, etc.) in the food processing industry. They are being investigated for their potential use in functional foods. However, phenolic compounds’ low bioavailability limits their application, which can be approached by loading the phenolic compounds into an encapsulation system such as liposomal carriers. This review aims to elucidate the recent trend in extracting phenolic compounds from the waste stream and the means to load them in stable liposomes. Furthermore, the application of these liposomes with only natural extracts in food matrices is also presented. Many studies have indicated that liposomes can be a proper candidate for encapsulating and delivering phenolic compounds and as a means to increase their bioavailability.

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References

  • Ajeeshkumar KK, Aneesh PA, Raju N, Suseela M, Ravishankar CN, Benjakul S. Advancements in liposome technology: Preparation techniques and applications in food, functional foods, and bioactive delivery: A review. Comprehensive Reviews in Food Science and Food Safety. 20: 1280-1306 (2021)

    CAS  PubMed  Google Scholar 

  • Alara OR, Abdurahman NH, Ukaegbu CI. Extraction of phenolic compounds: A review. Current Research in Food Science. 4: 200-214 (2021)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Alexandre EMC, Silva S, Santos SAO, Silvestre AJD, Duarte MF, Saraiva JA, Pintado M. Antimicrobial activity of pomegranate peel extracts performed by high pressure and enzymatic assisted extraction. Food Research International. 115: 167-176 (2019)

    CAS  PubMed  Google Scholar 

  • Altin G, Gültekin-Özgüven M, Ozcelik B. Chitosan coated liposome dispersions loaded with cacao hull waste extract: Effect of spray drying on physico-chemical stability and in vitro bioaccessibility. Journal of Food Engineering. 223: 91-98 (2018)

    CAS  Google Scholar 

  • Amado IR, Franco D, Sánchez M, Zapata C, Vázquez JA. Optimisation of antioxidant extraction from Solanum tuberosum potato peel waste by surface response methodology. Food Chemistry. 165: 290-299 (2014)

    CAS  PubMed  Google Scholar 

  • Amofa-Diatuo T, Anang DM, Barba FJ, Tiwari BK. Development of new apple beverages rich in isothiocyanates by using extracts obtained from ultrasound-treated cauliflower by-products: Evaluation of physical properties and consumer acceptance. Journal of Food Composition and Analysis. 61: 73-81 (2017)

    CAS  Google Scholar 

  • Andra VVSNL, Pammi SVN, Bhatraju LVKP, Ruddaraju LK. A comprehensive review on novel liposomal methodologies, commercial formulations, clinical trials and patents. BioNanoScience. 12: 274-291 (2022)

  • Asprea M, Tatini F, Piazzini V, Rossi F, Bergonzi MC, Bilia AR. Stable, monodisperse, and highly cell-permeating nanocochleates from natural soy lecithin liposomes. Pharmaceutics. 11: 34 (2019)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Assadpour E, Jafari SM. Nanoencapsulation: techniques and developments for food applications. Nanomaterials for Food Applications: 35-61 (2019)

  • Ballesteros-Vivas D, Álvarez-Rivera G, Morantes SJ, Sánchez-Camargo A del P, Ibáñez E, Parada-Alfonso F, Cifuentes A. An integrated approach for the valorization of mango seed kernel: Efficient extraction solvent selection, phytochemical profiling and antiproliferative activity assessment. Food Research International. 126: 108616 (2019)

  • Bao C, Jiang P, Chai J, Jiang Y, Li D, Bao W, Liu B, Liu B, Norde W, Li Y. The delivery of sensitive food bioactive ingredients: Absorption mechanisms, influencing factors, encapsulation techniques and evaluation models. Food Research International. 120: 130-140 (2019)

    CAS  PubMed  Google Scholar 

  • Bao Y, Reddivari L, Huang JY. Development of cold plasma pretreatment for improving phenolics extractability from tomato pomace. Innovative Food Science & Emerging Technologies. 65: 102445 (2020)

    CAS  Google Scholar 

  • Barreira JC, Arraibi AA, Ferreira IC. Bioactive and functional compounds in apple pomace from juice and cider manufacturing: Potential use in dermal formulations. Trends in Food Science & Technology. 90: 76-87 (2019)

    CAS  Google Scholar 

  • Ben Jeddou K, Kammoun M, Hellström J, Gutiérrez-Quequezana L, Rokka VM, Gargouri-Bouzid R, Ellouze-Chaabouni S, Nouri-Ellouz O. Profiling beneficial phytochemicals in a potato somatic hybrid for tuber peels processing: phenolic acids and anthocyanins composition. Food Science & Nutrition. 9: 1388-1398 (2021)

    CAS  Google Scholar 

  • Bitwell C, Indra S Sen, Luke C, Kakoma MK. A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants. Scientific African. 19: e01585 (2023)

  • Boafo GF, Magar KT, Ekpo MD, Qian W, Tan S, Chen C. The role of cryoprotective agents in liposome stabilization and preservation. International Journal of Molecular Sciences. 23: 12487 (2022)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Brahmi F, Merchiche F, Mokhtari S, Smail L, Guemghar-Haddadi H, Yalaoui-Guellal D, Achat S, Fahmi Elsebai M, Madani K, Boulekbache L. Optimization of some extraction parameters of phenolic content from apple peels and grape seeds and enrichment of yogurt by their powders: A comparative study. Journal of Food Processing and Preservation. 45: e15126 (2021)

    CAS  Google Scholar 

  • Cabajar AA, Siacor FDC, Lim KJA, Lobarbio CFY, Taboada EB. Application of statistical solvent mixture design in optimizing the solid-liquid extraction of phenolic compounds from mango seed kernels. Applied Science and Engineering Progress. 14: (2021)

  • Caballero-Guerrero B, Garrido-Fernández A, Fermoso FG, Rodríguez-Gutierrez G, Fernández-Prior MÁ, Reinhard C, Nyström L, Benítez-Cabello A, Arroyo-López FN. Antimicrobial effects of treated olive mill waste on foodborne pathogens. LWT - Food Science and Technology. 164: 113628 (2022)

    CAS  Google Scholar 

  • Caldas TW, Mazza KEL, Teles ASC, Mattos GN, Brígida AIS, Conte-Junior CA, Borguini RG, Godoy RLO, Cabral LMC, Tonon RV. Phenolic compounds recovery from grape skin using conventional and non-conventional extraction methods. Industrial Crops and Products. 111: 86-91 (2018)

    CAS  Google Scholar 

  • Cerda-Opazo P, Gotteland M, Oyarzun-Ampuero FA, Garcia L. Design, development and evaluation of nanoemulsion containing avocado peel extract with anticancer potential: A novel biological active ingredient to enrich food. Food Hydrocolloids. 111: 106370 (2021)

    CAS  Google Scholar 

  • Chadorshabi S, Hallaj-Nezhadi S, Ghasempour Z. Liposomal system based on lyophilization of a monophase solution for stabilization of bioactives from red onion skin. LWT - Food Science and Technology. 172: 114174 (2022)

    CAS  Google Scholar 

  • Chen BH, Inbaraj BS. Nanoemulsion and nanoliposome based strategies for improving anthocyanin stability and bioavailability. Nutrients. 11: 1052 (2019)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen R, Luo S, Wang C, Bai H, Lu J, Tian L, Gao M, Wu J, Bai C, Sun H. Effects of ultra-high pressure enzyme extraction on characteristics and functional properties of red pitaya (Hylocereus polyrhizus) peel pectic polysaccharides. Food Hydrocolloids. 121: 107016 (2021)

    CAS  Google Scholar 

  • Chockchaisawasdee S, Stathopoulos CE. Extraction, isolation and utilisation of bioactive compounds from fruit juice industry waste, pp. 272-313. In: Utilisation of Bioactive Compounds from Agricultural and Food Waste. Quan V. Vuong (ed). CRC Press, Inc., Boca Raton, FL, USA (2017)

  • Cory H, Passarelli S, Szeto J, Tamez M, Mattei J. The role of polyphenols in human health and food systems: A mini-review. Frontiers in Nutrition. 5: 370438 (2018)

    Google Scholar 

  • Dias R, Oliveira H, Fernandes I, Simal-Gandara J, Perez-Gregorio R. Recent advances in extracting phenolic compounds from food and their use in disease prevention and as cosmetics. 61: 1130-1151 (2020)

    Google Scholar 

  • Dima C, Assadpour E, Dima S, Jafari SM. Bioavailability of nutraceuticals: Role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems. Comprehensive Reviews in Food Science and Food Safety. 19: 954-994 (2020)

    CAS  PubMed  Google Scholar 

  • Dos Santos RG, Ventura P, Bordado JC, Mateus MM. Valorizing potato peel waste: An overview of the latest publications. Reviews in Environmental Science and Biotechnology. 15: 585-592 (2016)

    Google Scholar 

  • Ekorong Akouan Anta JF, Mbougueng PD, Durand E, Baréa B, Villeneuve P, Ndjouenkeu R. Model development to enhance the solvent extraction of polyphenols from mango seed kernel. Journal of biologically active products from nature. 8: 51-63 (2018)

  • El Kantar S, Boussetta N, Rajha HN, Maroun RG, Louka N, Vorobiev E. High voltage electrical discharges combined with enzymatic hydrolysis for extraction of polyphenols and fermentable sugars from orange peels. Food Research International. 107: 755-762 (2018)

    PubMed  Google Scholar 

  • El-Beltagi HS, El-Mogy MM, Parmar A, Mansour AT, Shalaby TA, Ali MR. Phytochemical characterization and utilization of dried red beetroot (Beta vulgaris) peel extract in maintaining the quality of nile tilapia fish fillet. Antioxidants. 11: 906 (2022)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Elik A, Yanık DK, Göğüş F. Microwave-assisted extraction of carotenoids from carrot juice processing waste using flaxseed oil as a solvent. LWT-Food Science and Technology. 123: 109100 (2020)

    CAS  Google Scholar 

  • El-Messery TM, El-Said MM, Farahat ESA. Production of functional processed cheese supplemented with nanoliposomes of mandarin peel extract. Pakistan Journal of Biological Sciences. 22: 247-256 (2019)

    CAS  PubMed  Google Scholar 

  • Esfanjani AF, Assadpour E, Jafari SM. Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers. Trends in Food Science & Technology. 76: 56-66 (2018)

    Google Scholar 

  • Faraone I, Lela L, Ponticelli M, Gorgoglione D, De Biasio F, Valentão P, Andrade PB, Vassallo A, Caddeo C, Falabella R, Ostuni A, Milella L. New insight on the bioactivity of solanum aethiopicum linn. growing in basilicata region (italy): phytochemical characterization, liposomal incorporation, and antioxidant effects. Pharmaceutics. 14: 1168 (2022)

  • Feng S, Sun Y, Wang P, Sun P, Ritzoulis C, Shao P. Co-encapsulation of resveratrol and epigallocatechin gallate in low methoxyl pectin-coated liposomes with great stability in orange juice. International Journal of Food Science & Technology. 55: 1872-1880 (2020)

    CAS  Google Scholar 

  • Fernandes F, Dias-Teixeira M, Delerue-Matos C, Grosso C. Critical review of lipid-based nanoparticles as carriers of neuroprotective drugs and extracts. Nanomaterials. 11: 563 (2021)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Frenzel M, Krolak E, Wagner AE, Steffen-Heins A. Physicochemical properties of WPI coated liposomes serving as stable transporters in a real food matrix. LWT - Food Science and Technology. 63: 527-534 (2015)

    CAS  Google Scholar 

  • Ganesh KS, Sridhar A, Vishali S. Utilization of fruit and vegetable waste to produce value-added products: Conventional utilization and emerging opportunities-A review. Chemosphere. 287: 132221 (2022)

    CAS  PubMed  Google Scholar 

  • Ganjian S, Javadian SR , Keshavarz M. Influence of encapsulated pomegranate peel extract on the chemical and microbial quality of silver carp (Hypophthalmichthys molitrix Val. 1844) fillet during refrigerating storage. Iranian Journal of Fisheries Sciences. 19: 994-1005 (2020)

  • Gibis M, Ruedt C, Weiss J. In vitro release of grape-seed polyphenols encapsulated from uncoated and chitosan-coated liposomes. Food Research International. 88: 105-113 (2016)

    CAS  PubMed  Google Scholar 

  • Gil LS, Maupoey PF. An integrated approach for pineapple waste valorisation. Bioethanol production and bromelain extraction from pineapple residues. Journal of Cleaner Production. 172: 1224-1231 (2018)

  • Goula AM, Thymiatis K, Kaderides K. Valorization of grape pomace: Drying behavior and ultrasound extraction of phenolics. Food and Bioproducts Processing. 100: 132-144 (2016)

    CAS  Google Scholar 

  • Grgić J, Šelo G, Planinić M, Tišma M, Bucić-Kojić A. Role of the encapsulation in bioavailability of phenolic compounds. Antioxidants. 9: 923 (2020)

    PubMed  PubMed Central  Google Scholar 

  • Gültekin-Özgüven M, Karadaʇ A, Duman Ş, Özkal B, Özçelik B. Fortification of dark chocolate with spray dried black mulberry (Morus nigra) waste extract encapsulated in chitosan-coated liposomes and bioaccessability studies. Food Chemistry. 201: 205-212 (2016)

    PubMed  Google Scholar 

  • Gulzar S, Benjakul S, Hozzein WN. Impact of β-glucan on debittering, bioaccessibility and storage stability of skim milk fortified with shrimp oil nanoliposomes. International Journal of Food Science & Technology. 55: 2092-2103 (2020)

    CAS  Google Scholar 

  • Guthrie F, Wang Y, Neeve N, Quek SY, Mohammadi K, Baroutian S. Recovery of phenolic antioxidants from green kiwifruit peel using subcritical water extraction. Food and Bioproducts Processing. 122: 136-144 (2020)

    CAS  Google Scholar 

  • Hasani O, Javadian SR. Effect of encapsulated bitter orange peel extract and bht on the quality of common carp fillet during refrigerated storage. International Journal of Food Engineering. 12: 303-310 (2016)

    CAS  Google Scholar 

  • Hashim MA, Huang X, Nadtochii LA, Baranenko DA, Boulkrane MS, El-Messery TM. Encapsulation of bioactive compounds extracted from date palm seeds (Phoenix dactylifera L.) and their use in functional food. Frontiers in Nutrition. 9: 1051050 (2022)

  • Hobbi P, Okoro OV, Delporte C, Alimoradi H, Podstawczyk D, Nie L, Bernaerts KV, Shavandi A. Kinetic modelling of the solid–liquid extraction process of polyphenolic compounds from apple pomace: influence of solvent composition and temperature. Bioresources and Bioprocessing. 8: 1-14 (2021)

    Google Scholar 

  • Hosseini SF, Ramezanzade L, McClements DJ. Recent advances in nanoencapsulation of hydrophobic marine bioactives: Bioavailability, safety, and sensory attributes of nano-fortified functional foods. Trends in Food Science & Technology. 109: 322-339 (2021)

    CAS  Google Scholar 

  • Hussain MB, Hassan S, Waheed M, Javed A, Adil Farooq M, Tahir A. Bioavailability and metabolic pathway of phenolic compounds, pp. 67-84. In: Plant physiological aspects of phenolic compounds. M. Soto-Hernández, M. Palma-Tenango, R. García-Mateos (Eds.). IntechOpen (2019)

  • Jahanfar S, Gahavami M, Khosravi-Darani K, Jahadi M, Mozafari MR. Entrapment of rosemary extract by liposomes formulated by Mozafari method: physicochemical characterization and optimization. Heliyon. 7: e08632 (2021)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jayanudin, Rochmadi, Fahrurrozi M , Wirawan SK. Microencapsulation technology of ginger oleoresin with chitosan as wall material: A review. Journal of Applied Pharmaceutical Science. 6: 209-223 (2016)

  • Karaś M, Jakubczyk A, Szymanowska U, Złotek U, Zielińska E. Digestion and bioavailability of bioactive phytochemicals. International Journal of Food Science & Technology. 52: 291-305 (2017)

    Google Scholar 

  • Katouzian I, Taheri RA. Preparation, characterization and release behavior of chitosan-coated nanoliposomes (chitosomes) containing olive leaf extract optimized by response surface methodology. Journal of Food Science and Technology. 58: 3430-3443 (2021)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kazemi M, Karim R, Mirhosseini H, Abdul Hamid A. Optimization of pulsed ultrasound-assisted technique for extraction of phenolics from pomegranate peel of Malas variety: Punicalagin and hydroxybenzoic acids. Food Chemistry. 206: 156-166 (2016)

    CAS  PubMed  Google Scholar 

  • Kosseva MR. Sources, characteristics and treatment of plant-based food waste, pp. 37-66. In: Food Industry Wastes: Assessment and Recuperation of Commodities. M. R. Kosseva, C. Webb (Eds.). Academic Press. (2020)

  • Krivokapić S, Vlaovi´cvlaovi´c M, Vratnica BD, Perovi´c A , Perovi´c S. Biowaste as a potential source of bioactive compounds—a case study of raspberry fruit pomace. Foods. 10: 706 (2021)

  • Kumar K, Yadav AN, Kumar V, Vyas P, Dhaliwal HS. Food waste: a potential bioresource for extraction of nutraceuticals and bioactive compounds. Bioresources and Bioprocessing. 4(1): 1-14 (2017)

    CAS  Google Scholar 

  • Kumari B, Tiwari BK, Hossain MB, Brunton NP, Rai DK. Recent advances on application of ultrasound and pulsed electric field technologies in the extraction of bioactives from agro-industrial by-products. Food and Bioprocess Technology. 11: 223-241 (2018)

    CAS  Google Scholar 

  • Lachos-Perez D, Baseggio AM, Mayanga-Torres PC, Maróstica MR, Rostagno MA, Martínez J, Forster-Carneiro T. Subcritical water extraction of flavanones from defatted orange peel. The Journal of Supercritical Fluids. 138: 7-16 (2018)

    CAS  Google Scholar 

  • Lachos-Perez D, Baseggio AM, Torres-Mayanga PC, Ávila PF, Tompsett GA, Marostica M, Goldbeck R, Timko MT, Rostagno M, Martinez J, Forster-Carneiro T. Sequential subcritical water process applied to orange peel for the recovery flavanones and sugars. The Journal of Supercritical Fluids. 160: 104789 (2020)

    CAS  Google Scholar 

  • Lasta HFB, Lentz L, Mezzomo N, Ferreira SRS. Supercritical CO2 to recover extracts enriched in antioxidant compounds from beetroot aerial parts. Biocatalysis and Agricultural Biotechnology. 19: 101169 (2019)

    Google Scholar 

  • Lee FY, Vo GT, Barrow CJ, Dunshea FR, Suleria HAR. Mango rejects and mango waste: Characterization and quantification of phenolic compounds and their antioxidant potential. Journal of Food Processing and Preservation. 45: e15618 (2021)

    CAS  Google Scholar 

  • Lin D, Xiao M, Zhao J, Li Z, Xing B, Li X, Kong M, Li L, Zhang Q, Liu Y, Chen H, Qin W, Wu H, Chen S. An overview of plant phenolic compounds and their importance in human nutrition and management of type 2 diabetes. Molecules. 21: 1374 (2016)

    PubMed  PubMed Central  Google Scholar 

  • Liu W, Tian M, Kong Y, Lu J, Li N, Han J. Multilayered vitamin C nanoliposomes by self-assembly of alginate and chitosan: Long-term stability and feasibility application in mandarin juice. LWT- Food Science and Technology. 75: 608-615 (2017)

    CAS  Google Scholar 

  • Liu W, Ye A, Han F, Han J. Advances and challenges in liposome digestion: Surface interaction, biological fate, and GIT modeling. Advances in Colloid and Interface Science. 263: 52-67 (2019)

    CAS  PubMed  Google Scholar 

  • Luca SV, Macovei I, Bujor A, Miron A, Skalicka-Woźniak K, Aprotosoaie AC, Trifan A. Bioactivity of dietary polyphenols: The role of metabolites. Critical Reviews in Food Science and Nutrition. 60: 626-659 (2020)

    CAS  PubMed  Google Scholar 

  • Machado APDF, Sumere BR, Mekaru C, Martinez J, Bezerra RMN, Rostagno MA. Extraction of polyphenols and antioxidants from pomegranate peel using ultrasound: influence of temperature, frequency and operation mode. International Journal of Food Science & Technology. 54: 2792-2801 (2019)

    CAS  Google Scholar 

  • Marín D, Alemán A, Montero P, Gómez-Guillén MC. Encapsulation of food waste compounds in soy phosphatidylcholine liposomes: Effect of freeze-drying, storage stability and functional aptitude. Journal of Food Engineering. 223: 132-143 (2018a)

    Google Scholar 

  • Marín D, Alemán A, Sánchez-Faure A, Montero P, Gómez-Guillén MC. Freeze-dried phosphatidylcholine liposomes encapsulating various antioxidant extracts from natural waste as functional ingredients in surimi gels. Food Chemistry. 245: 525-535 (2018b)

    PubMed  Google Scholar 

  • McClements DJ, Öztürk B. Utilization of nanotechnology to improve the application and bioavailability of phytochemicals derived from waste streams. Journal of Agricultural and Food Chemistry. 70: 6884-6900 (2021)

    PubMed  Google Scholar 

  • McClements DJ. Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals. Biotechnology Advances. 38: 107287 (2020)

    CAS  PubMed  Google Scholar 

  • Milinčić DD, Salević-Jelić AS, Kostić A, Stanojević SP, Nedović V, Pešić MB. Food nanoemulsions: how simulated gastrointestinal digestion models, nanoemulsion, and food matrix properties affect bioaccessibility of encapsulated bioactive compounds. Critical Reviews in Food Science and Nutrition. 1-23 (2023)

  • Montero-Calderon A, Cortes C, Zulueta A, Frigola A, Esteve MJ. Green solvents and ultrasound-assisted extraction of bioactive orange (Citrus sinensis) peel compounds. Scientific Reports. 9: 1-8 (2019)

    CAS  Google Scholar 

  • Naeem U, Arshad MU, Saeed F, Imran A. Extraction and characterization of polyphenols from fruits and vegetable waste through green extraction technologies with special reference to antioxidant profile. Journal of Food Processing and Preservation. 46: e16807 (2022)

    CAS  Google Scholar 

  • Nishad J, Saha S, Kaur C. Enzyme- and ultrasound-assisted extractions of polyphenols from Citrus sinensis (cv. Malta) peel: A comparative study. Journal of Food Processing and Preservation. 43: e14046 (2019)

  • Noore S, Rastogi NK, O’donnell C, Tiwari B, Agarwal R, Ruta G. Novel bioactive extraction and nano-encapsulation. Encyclopedia. 1: 632-664 (2021)

    Google Scholar 

  • Nunes MA, Pimentel F, Costa ASG, Alves RC, Oliveira MBPP. Cardioprotective properties of grape seed proanthocyanidins: An update. Trends in Food Science & Technology. 57: 31-39 (2016)

    CAS  Google Scholar 

  • Ozkan G, Kostka T, Esatbeyoglu T, Capanoglu E. Effects of lipid-based encapsulation on the bioaccessibility and bioavailability of phenolic compounds. Molecules. 25: 5545 (2020)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Padilla de la Rosa JD, Ruiz-Palomino P, Arriola-Guevara E, García-Fajardo J, Sandoval G, Guatemala-Morales GM. A green process for the extraction and purification of hesperidin from mexican lime peel (Citrus aurantifolia Swingle) that is extendible to the citrus genus. Processes. 6: 266 (2018)

  • Pagano I, Campone L, Celano R, Piccinelli AL, Rastrelli L. Green non-conventional techniques for the extraction of polyphenols from agricultural food by-products: A review. Journal of Chromatography A. 1651: 462295 (2021)

    CAS  PubMed  Google Scholar 

  • Pal CBT, Jadeja GC. Microwave-assisted deep eutectic solvent extraction of phenolic antioxidants from onion (Allium cepa L.) peel: a Box-Behnken design approach for optimization. Journal of Food Science and Technology. 56: 4211-4223 (2019)

  • Palmina NP, Maltseva EL, Binyukov VI, Kasparov VV, Antipova AS, Semenova MG. The structural state and form of free and biopolymer-encapsulated phosphatidylcholine liposomes in the absence and presence of natural plant antioxidants. Biophysics (Russian Federation). 63: 52-58 (2018)

    CAS  Google Scholar 

  • Panzella L, Moccia F, Nasti R, Marzorati S, Verotta L, Napolitano A. Bioactive phenolic compounds from agri-food wastes: an update on green and sustainable extraction methodologies. Frontiers in Nutrition. 7: 538169 (2020)

    Google Scholar 

  • Papoutsis K, Pristijono P, Golding JB, Stathopoulos CE, Bowyer MC, Scarlett CJ, Vuong Q V. Screening the effect of four ultrasound-assisted extraction parameters on hesperidin and phenolic acid content of aqueous citrus pomace extracts. Food Bioscience. 21: 20-26 (2018)

    CAS  Google Scholar 

  • Pateiro M, Gómez B, Munekata PES, Barba FJ, Putnik P, Bursa´c DB, Kovačevi´c K, Lorenzo JM, Pellegrino F, Cesano F, Fabbiani M, Negri C. Nanoencapsulation of promising bioactive compounds to improve their absorption, stability, functionality and the appearance of the final food products. Molecules. 26: 1547 (2021)

  • Pedroza MA, Amendola D, Maggi L, Zalacain A, De Faveri DM, Spigno G. Microwave-assisted extraction of phenolic compounds from dried waste grape skins. International Journal of Food Engineering. 11: 359-370 (2015)

    CAS  Google Scholar 

  • Pellicanò TM, Sicari V, Loizzo MR, Leporini M, Falco T, Poiana M. Optimizing the supercritical fluid extraction process of bioactive compounds from processed tomato skin byproducts. Food Science and Technology. 40: 692-697 (2019)

    Google Scholar 

  • Perra M, Lozano-Sánchez J, Leyva-Jiménez FJ, Segura-Carretero A, Pedraz JL, Bacchetta G, Muntoni A, De Gioannis G, Manca ML, Manconi M. Extraction of the antioxidant phytocomplex from wine-making by-products and sustainable loading in phospholipid vesicles specifically tailored for skin protection. Biomedicine & Pharmacotherapy. 142: 111959 (2021)

    CAS  Google Scholar 

  • Putnik P, Bursać Kovačević D, Režek Jambrak A, Barba FJ, Cravotto G, Binello A, Lorenzo JM, Shpigelman A. innovative ‘green’ and novel strategies for the extraction of bioactive added value compounds from citrus wastes-a review. Molecules (Basel, Switzerland). 22: (2017)

  • Raks V, Al-Suod H , Buszewski B. Isolation, separation, and preconcentration of biologically active compounds from plant matrices by extraction techniques. Chromatographia. 81: 189-202 (2017)

    PubMed  PubMed Central  Google Scholar 

  • Ranjbar N, Eikani MH, Javanmard M, Golmohammad F. Impact of instant controlled pressure drop on phenolic compounds extraction from pomegranate peel. Innovative Food Science & Emerging Technologies. 37: 177-183 (2016)

    CAS  Google Scholar 

  • Rashwan AK, Karim N, Xu Y, Xie J, Cui H, Mozafari MR, Chen W. Potential micro-/nano-encapsulation systems for improving stability and bioavailability of anthocyanins: An updated review. Critical Reviews in Food Science and Nutrition. 63: 3362-3385 (2021)

    PubMed  Google Scholar 

  • Rasouli H, Farzaei, MH, Khodarahmi R. Polyphenols and their benefits: A review. International Journal of Food Properties. 20: 1700-1741 (2017)

    CAS  Google Scholar 

  • Rifna EJ, Misra NN , Dwivedi M. Recent advances in extraction technologies for recovery of bioactive compounds derived from fruit and vegetable waste peels: A review. Critical Reviews in Food Science and Nutrition. 63: 719-752 (2021)

    PubMed  Google Scholar 

  • Rodriguez Garcia SL, Raghavan V. Green extraction techniques from fruit and vegetable waste to obtain bioactive compounds—A review. Critical Reviews in Food Science and Nutrition. 62: 6446-6466 (2022)

    CAS  PubMed  Google Scholar 

  • Sabaghi M, Tavasoli S, Hoseyni SZ, Mozafari MR, Degraeve P, Katouzian I. A critical review on approaches to regulate the release rate of bioactive compounds from biopolymeric matrices. Food Chemistry. 382: 132411 (2022)

    CAS  PubMed  Google Scholar 

  • Safaeian Laein S, Katouzian I, Mozafari MR, Farnudiyan-Habibi A, Akbarbaglu Z, Shadan MR, Sarabandi K. Biological and thermodynamic stabilization of lipid-based delivery systems through natural biopolymers; controlled release and molecular dynamics simulations. Critical Reviews in Food Science and Nutrition. 1-20 (2023)

  • Safdar MN, Kausar T, Jabbar S, Mumtaz A, Ahad K, Saddozai AA. Extraction and quantification of polyphenols from kinnow (Citrus reticulate L.) peel using ultrasound and maceration techniques. Journal of Food and Drug Analysis. 25: 488-500 (2017)

  • Saffarzadeh-Matin S, Khosrowshahi FM. Phenolic compounds extraction from Iranian pomegranate (Punica granatum) industrial waste applicable to pilot plant scale. Industrial Crops and Products. 108: 583-597 (2017)

    CAS  Google Scholar 

  • Sagar NA, Pareek S, Sharma S, Yahia EM, Lobo MG. Fruit and vegetable waste: Bioactive compounds, their extraction, and possible utilization. Comprehensive Reviews in Food Science and Food Safety. 17: 512-531 (2018)

    CAS  PubMed  Google Scholar 

  • Saini A, Panesar PS, Bera MB. Valorization of fruits and vegetables waste through green extraction of bioactive compounds and their nanoemulsions-based delivery system. Bioresources and Bioprocessing. 6(1): 1-12 (2019)

    Google Scholar 

  • Sai-Ut S, Benjakul S, Kraithong S, Rawdkuen S. Optimization of antioxidants and tyrosinase inhibitory activity in mango peels using response surface methodology. LWT - Food Science and Technology. 64: 742-749 (2015)

    CAS  Google Scholar 

  • Saykova I, Tylkowski B, Popovici C, Peev G. Extraction of phenolic and flavonoid compounds from solid wastes of grape seed oil production by cold pressing. Journal of Chemical Technology & Metallurgy. 53: 177-190 (2018)

    CAS  Google Scholar 

  • Sebaaly C, Trifan A, Sieniawska E, Greige-Gerges H. Chitosan-coating effect on the characteristics of liposomes: a focus on bioactive compounds and essential oils: A Review. Processes. 9: 445 (2021)

    CAS  Google Scholar 

  • Serino A, Salazar G. Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients. 11: 53 (2018)

    PubMed  Google Scholar 

  • Seyedabadi MM, Rostami H, Jafari SM, Fathi M. Development and characterization of chitosan-coated nanoliposomes for encapsulation of caffeine. Food Bioscience. 40: 100857 (2021)

    CAS  Google Scholar 

  • Shahidi F, Peng H. Bioaccessibility and bioavailability of phenolic compounds. Journal of Food Bioactives. 4: 11-68 (2018)

    Google Scholar 

  • Skenderidis P, Leontopoulos S, Petrotos K, Giavasis I. Optimization of vacuum microwave-assisted extraction of pomegranate fruits peels by the evaluation of extracts’ phenolic content and antioxidant activity. Foods. 9: 1655 (2020)

    CAS  Google Scholar 

  • Sogi DS, Siddiq M, Dolan KD. Total phenolics, carotenoids and antioxidant properties of Tommy Atkin mango cubes as affected by drying techniques. LWT - Food Science and Technology. 62: 564-568 (2015)

    CAS  Google Scholar 

  • Soquetta MB, Terra L de M, Bastos CP. Green technologies for the extraction of bioactive compounds in fruits and vegetables. CyTA-Journal of Food. 16: 400-412 (2018)

  • Tavakoli H, Hosseini O, Jafari SM, Katouzian I. Evaluation of physicochemical and antioxidant properties of yogurt enriched by olive leaf phenolics within nanoliposomes. Journal of Agricultural and Food Chemistry. 66: 9231-9240 (2018)

    CAS  PubMed  Google Scholar 

  • Thakur P, George N, Chakraborty M. Qualitative phytochemical screening of sweet orange (Citrus sinensis) peel extract-A preliminary study. Plant Cell Biotechnology and Molecular Biology: 29-34 (2020)

  • Trigo JP, Alexandre EMC, Saraiva JA, Pintado ME. High value-added compounds from fruit and vegetable by-products – Characterization, bioactivities, and application in the development of novel food products. Critical Reviews in Food Science and Nutrition. 60: 1388-1416 (2019)

    PubMed  Google Scholar 

  • Trucillo P, Campardelli R, Aliakbarian B, Perego P, Reverchon E. Supercritical assisted process for the encapsulation of olive pomace extract into liposomes. The Journal of Supercritical Fluids. 135: 152-159 (2018)

    CAS  Google Scholar 

  • Turrini F, Malaspina P, Giordani P, Catena S, Zunin P, Boggia R. Traditional decoction and puae aqueous extracts of pomegranate peels as potential low-cost anti-tyrosinase ingredients. Applied Sciences. 10: 2795 (2020)

    CAS  Google Scholar 

  • Velderrain-Rodríguez GR, Acevedo-Fani A, González-Aguilar GA, Martín-Belloso O. Encapsulation and stability of a phenolic-rich extract from mango peel within water-in-oil-in-water emulsions. Journal of Functional Foods. 56: 65-73 (2019)

    Google Scholar 

  • Victor MM, David JM, Cortez MVM, Leite JL, da Silva GSB. A high-yield process for extraction of hesperidin from orange (Citrus sinensis L. osbeck) peels waste, and its transformation to diosmetin, a valuable and bioactive flavonoid. Waste and Biomass Valorization. 12: 313-320 (2020)

  • Victor MM, David JM, Sakukuma MCK, França EL, Nunes AVJ. A simple and efficient process for the extraction of naringin from grapefruit peel waste. Green Processing and Synthesis. 7: 524-529 (2018)

    CAS  Google Scholar 

  • Villacís-Chiriboga J, Voorspoels S, Uyttebroek M, Ruales J, Camp J Van, Vera E, Elst K. Supercritical CO2 extraction of bioactive compounds from mango (Mangifera indica L.) peel and pulp. Foods. 10: 2201 (2021)

  • Vu HT, Scarlett CJ, Vuong QV. Changes of phytochemicals and antioxidant capacity of banana peel during the ripening process; with and without ethylene treatment. Scientia Horticulturae. 253: 255-262 (2019)

    CAS  Google Scholar 

  • Wang L, Boussetta N, Lebovka N, Vorobiev E. Effects of ultrasound treatment and concentration of ethanol on selectivity of phenolic extraction from apple pomace. International Journal of Food Science & Technology. 53: 2104-2109 (2018)

    CAS  Google Scholar 

  • Weremfo A, Adulley F, Adarkwah-Yiadom M. Simultaneous optimization of microwave-assisted extraction of phenolic compounds and antioxidant activity of avocado (Persea americana mill.) seeds using response surface methodology. Journal of Analytical Methods in Chemistry. 2020: (2020)

  • Xi J, He L , Yan L gong. Continuous extraction of phenolic compounds from pomegranate peel using high voltage electrical discharge. Food Chemistry. 230: 354-361 (2017)

  • Yin C, Cheng L, Zhang X, Wu Z. Nanotechnology improves delivery efficiency and bioavailability of tea polyphenols. Journal of Food Biochemistry. 44: e13380 (2020)

    CAS  PubMed  Google Scholar 

  • Yu JY, Chuesiang P, Shin GH, Park HJ. Post-processing techniques for the improvement of liposome stability. Pharmaceutics. 13: 1023 (2021)

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zema DA, Calabrò PS, Folino A, Tamburino V, Zappia G , Zimbone SM. Valorisation of citrus processing waste: A review. Waste Management. 80: 252-273 (2018)

    CAS  PubMed  Google Scholar 

  • Zhang J, Wang H, Ai C, Lu R, Chen L, Xiao J, Teng H. Food matrix-flavonoid interactions and their effect on bioavailability. Critical Reviews in Food Science and Nutrition: 1-22 (2023)

  • Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: A comprehensive review. Chinese Medicine (United Kingdom). 13: 1-26 (2018)

    Google Scholar 

  • Zheng G, Wang K, Chen B, Liu M, Yang W, Ning J, Cai Y, Wei M. The enhanced solubility and anti-lipase activity of citrus peel polymethoxyflavonoids extracts with liposomal encapsulation. LWT - Food Science and Technology. 161: 113395 (2022)

    CAS  Google Scholar 

  • Zuorro A, Maffei G, Lavecchia R. Reuse potential of artichoke (Cynara scolimus L.) waste for the recovery of phenolic compounds and bioenergy. Journal of Cleaner Production. 111: 279-284 (2016)

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Thiruvalluvan, M., Kaur, B.P., Singh, A. et al. Enhancement of the bioavailability of phenolic compounds from fruit and vegetable waste by liposomal nanocarriers. Food Sci Biotechnol 33, 307–325 (2024). https://doi.org/10.1007/s10068-023-01458-z

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