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Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil

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Abstract

The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8 times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC0–8 increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S (p < 0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT, Ministry of Science and ICT) (No. 2021R1F1A1062871 and 2018R1C1B6008236).

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Author notes

  1. Tae Kyung Lee and Gihyun Hur have equally contributed to this work as co-first authors.

Authors and Affiliations

  1. Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea

    Tae Kyung Lee, Gihyun Hur & Ki Won Lee

  2. Department of Next Generation Applied Sciences, Graduate School, Sungshin Women’s University, Seoul, 01133, Republic of Korea

    Jeongyoon Choi

  3. Department of Environmental Horticulture, University of Seoul, Seoul, 02504, Republic of Korea

    Choongjin Ban

  4. Department of Food Science and Biotechnology, Institute of Fermentation and Brewing, Kangwon National University, Chuncheon, 24341, Republic of Korea

    Jong-Yea Kim

  5. Department of Food and Nutrition, Kookmin University, Seoul, 02707, Republic of Korea

    Hee Yang

  6. Bio-MAX Institute, Seoul National University, Seoul, 08826, Republic of Korea

    Jung Han Yoon Park & Ki Won Lee

  7. Advanced Institute of Convergence Technology, Seoul National University, Suwon, 16229, Republic of Korea

    Ki Won Lee

  8. Department of Food Science and Biotechnology, Institute for Basic Sciences, Sungshin Women’s University, Seoul, 01133, Republic of Korea

    Jong Hun Kim

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  1. Tae Kyung Lee
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Lee, T.K., Hur, G., Choi, J. et al. Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil. Food Sci Biotechnol 32, 1269–1279 (2023). https://doi.org/10.1007/s10068-023-01304-2

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  • DOI: https://doi.org/10.1007/s10068-023-01304-2

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