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Antioxidant activity and protective effect of methyl gallate against t-BHP induced oxidative stress through inhibiting ROS production

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the major diseases of chronic liver damage caused by oxidative stress. In this study, we investigated hepatoprotective effect of methyl gallate (MG) against t-BHP induced oxidative stress. Our results revealed that MG possessed strong antioxidant activity and lipid peroxidation inhibitory activity. In addition, MG inhibited t-BHP induced cell cytotoxicity, ROS production and sub-G1 phase cells in Chang liver cells. MG attenuated also activated signal p38 and decreased mitochondrial-mediated cell death by regulating pro- and anti- apoptotic proteins. Our results indicate that MG could be potentially used as protective agent in NAFLD therapy by modulating oxidative stress.

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Acknowledgements

This paper was supported by the Semyung University Research Grant 2021.

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  1. Department of Applied Life Science, Konkuk University, Chungju, 27478, Korea

    Bo-Im Ryu

  2. Department of Korean Medicine, Semyung University, Jecheon, 27136, Korea

    Ki-Tae Kim

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  1. Bo-Im Ryu
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Ryu, BI., Kim, KT. Antioxidant activity and protective effect of methyl gallate against t-BHP induced oxidative stress through inhibiting ROS production. Food Sci Biotechnol 31, 1063–1072 (2022). https://doi.org/10.1007/s10068-022-01120-0

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