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Roasted garlic protects against leaky gut syndrome in dextran sodium sulfate-induced colitis mice

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Abstract

Garlic (Allium sativum) is a potentially beneficial functional food that is extensively grown around the globe. We have investigated the effect of roasted garlic on a dextran sodium sulfate (DSS)-induced intestinal permeability model in mice. Mice were divided into four diet groups: CON, DSS, RG (roasted garlic), and RG + Purple bamboo salt (RGP) in the AIN 93G diet for 3 weeks. All groups except the CON group received 2% DSS in drinking water at the last week of the experiment. DSS groups showed significantly elevated gut permeability levels and decreased tight junction protein expression compared to CON. However, RG and RGP displayed remarkably lower trends of gut permeability, increased tight junction protein expression, increased number of goblet cells than the DSS group in hematoxylin and eosin and alcian blue-nuclear fast red stained colon sections. These results indicate that roasted garlic could prevent gut leakage induced by DSS.

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Acknowledgements

This study was supported by the “Leaders in Industry-university cooperation +” Project which was funded by the Ministry of Education and National Research Foundation of Korea.

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  1. Divya Sharma and Madhuri Sangar have contributed equally to this work.

Authors and Affiliations

  1. Department of Food Engineering and Solar Salt Research Center, Mokpo National University, Muan-gun, South Korea

    Divya Sharma, Madhuri Sangar, Jeom-Leon Park, Seong-Gook Kang & Kyung-Sik Ham

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  1. Divya Sharma
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  2. Madhuri Sangar
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Correspondence to Kyung-Sik Ham.

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Sharma, D., Sangar, M., Park, JL. et al. Roasted garlic protects against leaky gut syndrome in dextran sodium sulfate-induced colitis mice. Food Sci Biotechnol 31, 1335–1342 (2022). https://doi.org/10.1007/s10068-022-01116-w

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