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In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing

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Abstract

The present study assesses hepatoprotective effects of raw oyster lyophilized powder (OP) and subcritical water treated oyster powder (SOP) on D-galactosamine (D-GalN)-induced toxicity and acute ethanol intoxication in mice. High-performance liquid chromatography analysis revealed that four phenolic compounds and glucose were identified from the SOP. The levels of aspartate aminotransferase, alanine aminotransferase, and malondialdehyde were considerably lower for the oyster extracts and the levels of glutathione, γ-glutamylcysteinesynthetase, glutathione S-transferase, and glutathione reductase were higher in the D-GalN induced mice compared with those in the controls. Histology analysis suggested that SOP can protect against and heal the D-GalN toxified liver. For the acute ethanol intoxication study, the enzymatic activity of acetaldehyde dehydrogenase and SOP’s alcohol dehydrogenase appeared better than that of OP. Overall, SOP may protect the liver from acute ethanol intoxication and D-GalN persuaded hepatitis.

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Acknowledgements

This work (C0550312) was supported by Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2017.

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Authors and Affiliations

  1. Department of Food and Nutrition, Kyungsung University, 309 Suyeong-ro, Nam-gu, Busan, 48434, Republic of Korea

    Hee-Jeong Lee

  2. Department of Food Chemistry and Technology, Teagasc Food Research Centre, Ashtown, Dublin, Ireland

    Periaswamy Sivagnanam Saravana

  3. Department of Food Science and Technology, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan, 48513, Republic of Korea

    Truc Cong Ho, Jin-Seok Park & Byung-Soo Chun

  4. Bio-MAX Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea

    Yeon-Jin Cho

  5. Hallyo Enchovy, 277 Dusong-ro, Saha-gu, Busan, 49460, Republic of Korea

    Sang-Gyu Lee

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  1. Hee-Jeong Lee
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  2. Periaswamy Sivagnanam Saravana
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Lee, HJ., Saravana, P.S., Ho, T.C. et al. In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing. Food Sci Biotechnol 30, 1063–1074 (2021). https://doi.org/10.1007/s10068-021-00941-9

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