Effect of water-soluble propolis administration on the ethanol-induced hangover in rats

Abstract

Water soluble propolis was prepared using β–cyclodextrin, and its effect on an ethanol-induced hangover was examined in Sprague–Dawley (SD) rats fed with ethanol. When SD rats were administrated with propolis 30 min after ethanol feeding, ethanol content in the rat serum decreased 2.1 times 1 h after ethanol feeding. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity in rat liver increased 3.0 and 4.4 times, respectively, 1 h after ethanol feeding and administration of propolis 30 min after ethanol feeding. There were no differences in the expression of ADH and ALDH genes regardless of propolis administration. These results indicated that a decrease in ethanol content in the serum was not due to an increase in the expression of ADH or ALDH genes but rather, an increase in activities of ADH and ALDH.

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Acknowledgments

This work (Grant No. C0276516) was supported by Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2015.

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Correspondence to Young-Seo Park.

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Lee, S., Park, YS. Effect of water-soluble propolis administration on the ethanol-induced hangover in rats. Food Sci Biotechnol 30, 455–463 (2021). https://doi.org/10.1007/s10068-020-00869-6

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Keywords

  • Propolis
  • Water soluble propolis
  • Hangover-relieving drink
  • Alcohol dehydrogenase
  • Aldehyde dehydrogenase