Skip to main content
SpringerLink
Log in

Highly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate (MIA)-induced osteoarthritis

  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin® (TC) in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Seventy-seven male Wistar rats were divided into six groups: normal, negative control (MIA only), positive control (Cerebrex), and three experimental groups treated with 500, 1300, or 2600 mg/kg of TC for 5 weeks. MIA injection-induced OA caused 30% weight-bearing imbalance whereas weight bearing imbalance was significantly improved in the TC groups. Mankin scores revealed TC treatment had significantly ameliorated cartilage damage and chondrocyte decrease. The expressions of nitrotyrosine, tumor necrosis factor-α, phosphorylated nuclear factor kappa B cells, and cleaved caspase-3 were markedly increased in rat with MIA-induced OA, but the TC-treated groups exhibited a significant reduction in the number of immunoreactive cells in a dose-dependent manner. In conclusion, administration of TC contributes to the anti-arthritic effect in rat with MIA-induced OA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  • Ahmed U, Anwar A, Savage RS, Thornalley PJ, Rabbani N. Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease. Arthritis Res. Ther. 18: 250-260 (2016)

    Article  Google Scholar 

  • Bjarnason I. Gastrointestinal safety of NSAIDs and over-the-counter analgesics. Int. J. Clin. Pract. Suppl. 178: 37-42 (2013)

    Article  Google Scholar 

  • Chin KY. The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des. Dev. Ther. 10: 3029-3042 (2016)

    Article  CAS  Google Scholar 

  • Choi JS, Shin HS, Kim KY, Ku SK, Choi IS, Kim JW. Effect of polycalcium, a mixture of polycan and calcium lactate-gluconate in a 1:9 weight ratio, on rats with surgery-induced osteoarthritis. Exp. Ther. Med. 9: 1780-1790 (2015)

    Article  CAS  Google Scholar 

  • Cui Q, Li X, Zhu H. Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway. Mol. Med. Rep. 13: 1381-1388 (2016)

    Article  CAS  Google Scholar 

  • Dias RG, Sampaio SC, Sant’Anna MB, Cunha FQ, Gutiérrez JM, Lomonte B, Cury Y, Picolo G. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect. J. Venom. Anim. Toxins Incl. Trop. Dis. 23: 18-31 (2017)

  • El-Far YM, Zakaria MM, Gabr MM, El Gayar AM, Eissa LA, El-Sherbiny IM. Nanoformulated natural therapeutics for management of streptozotocin-induced diabetes: potential use of curcumin nanoformulation. Nanomed. (Lond.) 12: 1689-1711 (2017)

    Article  CAS  Google Scholar 

  • Feng T, Wei Y, Lee RJ, Zhao L. Liposomal curcumin and its application in cancer. Int. J. Nanomed. 12: 6027-6044 (2017)

    Article  CAS  Google Scholar 

  • Hardin JA, Cobelli N, Santambrogio L. Consequences of metabolic and oxidative modifications of cartilage tissue. Nat. Rev. Rheumatol. 11: 521-529 (2015)

    Article  CAS  Google Scholar 

  • Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P. American college of rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 64: 465-474 (2012)

    Article  CAS  Google Scholar 

  • Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J. Exp. Med. 196: 77-85 (2002)

    Article  CAS  Google Scholar 

  • Jiang L, Li L, Geng C, Gong D, Jiang L, Ishikawa N, Kajima K, Zhong L. Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro. J. Orthop. Res. 31: 364-369 (2013)

    Article  CAS  Google Scholar 

  • Kaur H, Halliwel B. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett. 350: 9-12 (1994)

    Article  CAS  Google Scholar 

  • Lee DG, Park SY, Chung WS, Park JH, Hwang E, Mavlonov GT, Kim IH, Kim KY, Yi TH. Fucoidan prevents the progression of osteoarthritis in rats. J. Med. Food. 18: 1032-1041 (2015)

    Article  CAS  Google Scholar 

  • Lee HS. Prevalence of osteoarthritis and related risk factors in the elderly: data from the fifth Korea National Health and Nutrition Examination Survey, 2010–2012. J. Korean Diet. Assoc. 20: 99-109 (2014)

    Article  Google Scholar 

  • Marcu KB, Otero M, Olivotto E, Borzi RM, Goldring MB. NF-kappaB signaling: multiple angles to target OA. Curr. Drug Targets 11: 599-613 (2010)

    Article  CAS  Google Scholar 

  • Moon SJ, Jeong JH, Jhun JY, Yang EJ, Min JK, Choi JY, Cho ML. Ursodeoxycholic Acid ameliorates pain severity and cartilage degeneration in monosodium iodoacetate-induced osteoarthritis in rats. Immune Netw. 14: 45-53 (2014)

    Article  Google Scholar 

  • Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J. Orthop. Sci. 19: 933-939 (2014)

    Article  CAS  Google Scholar 

  • Nelson AE. Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartil. 26: 319-325 (2018)

    Article  CAS  Google Scholar 

  • Niazvand F, Khorsandi L, Abbaspour M, Orazizadeh M, Varaa N, Maghzi M, Ahmadi K. Curcumin-loaded poly lactic-co-glycolic acid nanoparticles effects on monoiodoacetate-induced osteoarthritis in rats. Vet. Res. Forum 8: 155-161 (2017)

    PubMed  PubMed Central  Google Scholar 

  • Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin. Nutr. 34: 1101-1108 (2015)

    Article  CAS  Google Scholar 

  • Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, Sahebkar A. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post hoc analysis of a randomized controlled trial. Biomed. Pharmacother. 82: 578-582 (2016)

    Article  CAS  Google Scholar 

  • Richardot P, Charni-Ben Tabassi N, Toh L, Marotte H, Bay-Jensen AC, Miossec P, Garnero P. Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis. Osteoarthritis Cartil. 17: 1362-1367 (2009)

    Article  CAS  Google Scholar 

  • Roman-Blas JA, Jimenez SA. NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartil. 14: 839-848 (2006)

    Article  CAS  Google Scholar 

  • Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T. Innovative preparation of curcumin for improved oral bioavailability. Biol. Pharm. Bull. 34: 660-665 (2011)

    Article  CAS  Google Scholar 

  • Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, Pirmohamed M, Marnett LJ, Gescher AJ, Steward WP. Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer. Clin. Cancer Res. 7: 1894-1900 (2001)

    CAS  PubMed  Google Scholar 

  • Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, Lahey LJ, Lindstrom TM, Hwang I, Boyer KA, Andriacchi TP, Robinson WH. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res. Ther. 14: R7 (2012)

    Article  CAS  Google Scholar 

  • Soltani B, Bodaghabadi N, Ghaemi N, Sadeghizadeh M. Radiation-induced surge of macrophage foam cell formation, oxidative damage, and cytokine release is attenuated by a nanoformulation of curcumin. Int. J. Radiat. Biol. 93: 303-314 (2017)

    Article  CAS  Google Scholar 

  • Takahashi M, Uechi S, Takara K, Asikin Y, Wada K. Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J. Agric. Food Chem. 57: 9141-9146 (2009)

    Article  CAS  Google Scholar 

  • Tantavisut S, Tanavalee A, Honsawek S, Suantawee T, Ngarmukos S, Adisakwatana S, Callaghan JJ. Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study. BMC Musculoskelet. Disord. 18: 281-289 (2017)

    Article  Google Scholar 

  • Trivedi MK, Mondal SC, Gangwar M, Jana S. Immunomodulatory potential of nanocurcumin-based formulation. Inflammopharmacology 25: 609-619 (2017)

    Article  CAS  Google Scholar 

  • Wan S, Sun Y, Qi X, Tan F. Improved bioavailability of poorly water-soluble drug curcumin in cellulose acetate solid dispersion. AAPS PharmSciTech. 13: 159-166 (2012)

    Article  CAS  Google Scholar 

  • Watt FE. Osteoarthritis biomarkers: year in review. Osteoarthritis Cartil. 26: 312-318 (2018)

    Article  CAS  Google Scholar 

  • Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. USA. 89: 9784-9788 (1992)

    Article  CAS  Google Scholar 

  • Yang KY, Lin LC, Tseng TY, Wang SC, Tsai TH. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 853: 183-189 (2007)

    Article  CAS  Google Scholar 

  • Zhang Z, Leong DJ, Xu L, He Z, Wang A, Navati M, Kim SJ, Hirsh DM, Hardin JA, Cobelli NJ, Friedman JM, Sun HB. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res. Ther. 18: 128-139 (2016)

    Article  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge Prof. Ku, Sae Kwang for histopathological and immunohistochemistrical analysis.

Author information

Authors and Affiliations

  1. Gyeonggi Bio Research Center, Chemon Inc., Gwanggyo-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16229, Korea

    Hyun-Ji Park, Chul-Kyu Lee & Si-Hwan Song

  2. Handok Inc., 132 Teheran Street, Gangnam-gu, Seoul, 06235, Korea

    Jee-Hye Yun & Ahsa Lee

  3. Department of Food and Nutrition, Yuhan University, 590 Gyeongin-ro, Bucheon-si, Gyeonggi-do, 14780, Korea

    Hee-Jung Park

Authors
  1. Hyun-Ji Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chul-Kyu Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Si-Hwan Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jee-Hye Yun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ahsa Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hee-Jung Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

This study was partially designed and planned by Jee-Hye Yun and Ahsa Lee.

Corresponding author

Correspondence to Hee-Jung Park.

Ethics declarations

Conflict of interest

This study was supported by research fund from Handok Inc. Jee-Hye Yun and Ahsa Lee were an employment at Handok Inc.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Park, HJ., Lee, CK., Song, SH. et al. Highly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate (MIA)-induced osteoarthritis. Food Sci Biotechnol 29, 251–263 (2020). https://doi.org/10.1007/s10068-019-00679-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-019-00679-5

Keywords

Search

Navigation