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Protective effects of Gastrodia elata Blume on acetaminophen-induced liver and kidney toxicity in rats

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Abstract

An overdose of acetaminophen (AAP) causes hepatic and renal toxicity. This study examined the protective effects of Gastrodia elata Blume (GEB) on hepatic and renal injury induced by AAP. Rats were orally administered distilled water or GEB for 14 days and injected with AAP 1 h after the oral last administration; control rats were administered water without AAP injection. All rats were sacrificed 24 h after AAP injection. The GEB pretreatment group showed decreased necrosis and the expression of pro-inflammatory cytokines in the liver and kidney. TUNEL-positive cells and oxidative stress marker, such as malondialdehyde, were decreased. However, antioxidant enzymes, such as glutathione and superoxide dismutase, were increased. The expression of CYP2E1 and N-acetyl-beta-d-glucosaminidase was decreased in the GEB pretreatment group. This study shows that GEB prevents AAP-induced liver and kidney injury.

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Acknowledgements

This study was supported by Brain Korea 21 Plus (No. 31Z20130012916), and Jeonju University Industry-Academia Collaboration Foundation (J-H. Shin, 2015).

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Authors and Affiliations

  1. Department of Senior Healthcare, BK21 Plus Program, Graduate School, Eulji University, Seongnam-si, Gyunggi-do, 13135, Republic of Korea

    Pu Reum Seok, Hye Ri Kwon, Jin Sun Heo & Jae-Ho Shin

  2. Department of Food Technology and Service, Eulji University, Seongnam-si, Gyunggi-do, 13135, Republic of Korea

    Jung Hoan Kim

  3. Muju Wellness Food Project Team, Jeonju University, Jeonju-si, Jeonrabuk-do, 55069, Republic of Korea

    Jong Ryeol Choi

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  1. Pu Reum Seok
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  2. Jung Hoan Kim
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Correspondence to Jae-Ho Shin.

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Seok, P.R., Kim, J.H., Kwon, H.R. et al. Protective effects of Gastrodia elata Blume on acetaminophen-induced liver and kidney toxicity in rats. Food Sci Biotechnol 27, 1445–1454 (2018). https://doi.org/10.1007/s10068-018-0374-5

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