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Food Science and Biotechnology

, Volume 27, Issue 4, pp 1193–1200 | Cite as

Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment

  • Young-Min Seo
  • Soo Jung Choi
  • Chan Kyu Park
  • Min Chul Gim
  • Dong-Hoon Shin
Article
  • 65 Downloads

Abstract

Many edible plant extracts exhibit biological activities. For example, the ethanol extract of Pueraria montana var. lobata (P. montana) inhibits acetylcholinesterase (AChE), and red ginseng is well known for promoting health. In this study the authors investigated the synergistic effect of P. montana and red ginseng extracts on AChE activity in vitro and in mouse brain tissues and trimethyltin (TMT)-induced cognitive impairment in a mouse model of TMT-induced neurodegeneration. A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments in Y-maze and passive avoidance behavioral tests. In addition, the mixture inhibited AChE activity and lipid peroxidation synergistically.

Keywords

Alzheimer’s disease Learning Memory Pueraria montana var. lobata Red ginseng 

Notes

Acknowledgements

This work was supported by a Korea University Grant.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Young-Min Seo
    • 1
    • 2
  • Soo Jung Choi
    • 3
  • Chan Kyu Park
    • 1
  • Min Chul Gim
    • 1
  • Dong-Hoon Shin
    • 1
  1. 1.Department of Food and BiotechnologyKorea UniversitySeoulRepublic of Korea
  2. 2.Laboratory of Product Development, R&D HeadquartersKorea Ginseng CorporationDaejeonRepublic of Korea
  3. 3.Functional Food Research CenterKorea UniversitySeoulRepublic of Korea

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