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Kiwifruit of Actinidia eriantha cv. Bidan has in vitro antioxidative, anti-inflammatory and immunomodulatory effects on macrophages and splenocytes isolated from male BALB/c mice

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Abstract

Kiwifruit is known to contain considerable amount of antioxidative phenolics. The objective of this study was to evaluate the antioxidative, anti-inflammatory and immunomodulatory effects of Actinidia eriantha cv. Bidan and A. deliciosa cv. Hayward kiwifruits. The antioxidant capacity of kiwifruit was measured with the DPPH, ABTS and ORAC assays, and was significantly (p < 0.05) higher in cv. Bidan than in cv. Hayward. The production of proinflammatory cytokines interleukin-6, interleukin-12 and tumor necrosis factor-α by peritoneal macrophages from male BALB/c mice was significantly (p < 0.05) lower following treatment of cv. Bidan extracts than after treatment with lipopolysaccharide alone. Cv. Bidan extracts significantly (p < 0.05) increased the proliferation of splenocytes stimulated with an anti-CD3 antibody and significantly (p < 0.05) reduced their interferon-γ secretion. Taken together, these findings suggest that cv. Bidan kiwifruit is rich in antioxidants and may be a source of anti-inflammatory and immunomodulatory agents.

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Acknowledgements

This research was supported by the Agricultural Biotechnology Development Program (Project No. 114076-3), Ministry of Agriculture, Food and Rural Affairs, Republic of Korea.

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Authors and Affiliations

  1. Department of Food Science and Biotechnology, Kyung Hee University, Yongin, Gyeonggi, 17104, South Korea

    Young-Eun Kim, Chi-Heung Cho & Dae-Ok Kim

  2. Skin Biotechnology Center, Kyung Hee University, Suwon, Gyeonggi, 16229, South Korea

    Young-Eun Kim, Chi-Heung Cho & Dae-Ok Kim

  3. Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Gyeonggi, 17104, South Korea

    Hee Kang

  4. Division of Applied Life Science (BK21 Plus), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, Gyeongnam, 52828, South Korea

    Ho Jin Heo

  5. Jeollanamdo Agricultural Research and Extension Services, Naju, Jeonnam, 58213, South Korea

    Youn-Sup Cho

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  1. Young-Eun Kim
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Kim, YE., Cho, CH., Kang, H. et al. Kiwifruit of Actinidia eriantha cv. Bidan has in vitro antioxidative, anti-inflammatory and immunomodulatory effects on macrophages and splenocytes isolated from male BALB/c mice. Food Sci Biotechnol 27, 1503–1511 (2018). https://doi.org/10.1007/s10068-018-0321-5

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  • DOI: https://doi.org/10.1007/s10068-018-0321-5

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