Food Science and Biotechnology

, Volume 27, Issue 2, pp 565–573 | Cite as

Immuno-enhancement effect of polysaccharide extracted from Stichopus japonicus on cyclophosphamide-induced immunosuppression mice

  • Chaiwat Monmai
  • Sung Hee Park
  • SangGuan You
  • Woo Jung Park


Polysaccharide (SJP) was extracted from Sea cucumber, Stichopus japonicas, and its immune-enhancing activities were evaluated in vivo immune-suppressed mice systems. Cyclophosphamide(CY)-treated mice were orally administrated with SJP according to different concentrations. The results showed that administration of SJP significantly increased spleen index without variation of the body weight, compared to only CY treatment group. The proliferation of splenic lymphocyte and NK activity was also stimulated by SJP. In addition, the oral administration of SJP up-regulated COX-2 and TLR-4 as well as cytokines such as IL-1β, IL-4, IL-6, IL-10, TNF-α and IFN-γ, which are secreted from splenic lymphocytes in cyclophosphamide-treated mice. Moreover, our results showed that SJP stimulated macrophages via NF-κB and MAPK signaling pathways. These findings provided the potential use of SJP as an alternative means under immune-suppressed conditions, and furthermore can be utilized as a functional material for food and pharmaceutical industries.


Polysaccharide Sea cucumber Immunity Enhancement In vivo mice 



This study was supported by the Marine Bio-Regional Specialization Leading Technology Development Program (D11413914H480000100) funded by the Ministry of Oceans and Fisheries in Korea.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Chaiwat Monmai
    • 1
  • Sung Hee Park
    • 1
  • SangGuan You
    • 1
  • Woo Jung Park
    • 1
  1. 1.Department of Marine Food Science and TechnologyGangneung-Wonju National UniversityGangneungKorea

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