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Artemisia scoparia attenuates amyloid β accumulation and tau hyperphosphorylation in spontaneously hypertensive rats

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Abstract

The preventive effects of Artemisia scoparia extract (AS) and AS + garlic extract (ASG) on the risk of Alzheimer’s disease (AD) were evaluated in spontaneously hypertensive rats. Rats were supplemented with diets containing 2% (w/w) of AS or ASG for 6 weeks. The AS group showed lower levels of amyloid β and beta-site amyloid precursor protein cleaving enzyme 1 expressions and higher expression levels of low-density lipoprotein receptor-related protein 1 than did the control group (p < 0.05). In addition, the AS showed remarkably reduced levels of phosphorylated tau proteins and suppressed expression of phosphorylated glycogen synthase kinase 3β at tyrosine 216 (active form) (p < 0.05). The ASG group also suppressed amyloid β accumulation and tau hyperphosphorylation. However, there was no synergistic effect of garlic with AS in lowering the risk of AD. These results indicate that AS could be a potential candidate to ameliorate the risk of AD.

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Acknowledgements

This work was supported by Grant 20130290 to the Solar Salt Research Center of Mokpo National University from the Ministry of Oceans and Fisheries of Korea.

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  1. Department of Food Engineering and Solar Salt Research Center, Mokpo National University, Muan, Jeonnam, 58554, Republic of Korea

    Kitipong Promyo, Jeong-Yong Cho, Kyung-Hee Park, Lily Jaiswal, Sun-Young Park & Kyung-Sik Ham

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  1. Kitipong Promyo
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Correspondence to Kyung-Sik Ham.

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Promyo, K., Cho, JY., Park, KH. et al. Artemisia scoparia attenuates amyloid β accumulation and tau hyperphosphorylation in spontaneously hypertensive rats. Food Sci Biotechnol 26, 775–782 (2017). https://doi.org/10.1007/s10068-017-0077-3

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  • DOI: https://doi.org/10.1007/s10068-017-0077-3

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