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Dietary hydroxycinnamates prevent oxidative damages to liver, spleen, and bone marrow cells in irradiation-exposed mice

Food Science and Biotechnology volume 26, pages 279–285 (2017)Cite this article

Abstract

Dietary hydroxycinnamates are considered as attractive materials for radioprotection. This study explores whether hydroxycinnamates protect against γ-radiation-induced cellular damages and hematopoietic stem cell senescence. C57BL/6 mice were orally administered with each of caffeic acid, p-coumaric acid, and ferulic acid (20mg/kg body weight) once per three days for five times before exposure to total body radiation (5 Gy). Irradiation increased the activities of alanine amino transaminase and aspartate aminotransferase in blood serum but decreased the anti-oxidant defense enzyme activities in the liver and spleen tissues. Oral administration of the compounds almost completely prevented irradiation-mediated changes in these enzyme activities. The hydroxycinnamates also inhibited the irradiation-mediated increases in the mitochondrial superoxide anions of Lin−Sca-1+c-Kit+ (LSK) cells and CD150+CD48− LSK cells in the bone marrow. These results suggest that dietary hydroxycinnamates protect against irradiation-mediated oxidative damages of tissues and bone marrow progenitor cells.

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Affiliations

  1. Cluster for Craniofacial Development & Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Chonbuk National University, Jeonju, Jeonbuk, 54896, Korea

    Sung-Ho Kook, Min-Kook Kim & Jeong-Chae Lee

  2. Department of Bioactive Material Sciences and Research Center of Bioactives Materials, Chonbuk National University, Jeonju, Jeonbuk, 54896, Korea

    Sung-Ho Kook, Sa-Ra Cheon & Jeong-Chae Lee

  3. Chonnam National University Dental Hospital, Kwangju, 61186, Korea

    Jae-Hwan Kim

  4. Grassland and Forages Research Center, National Institute of Animal Science, Cheonan, Chungnam, 31002, Korea

    Ki-Choon Choi

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  1. Sung-Ho Kook
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  2. Sa-Ra Cheon
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  4. Ki-Choon Choi
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  5. Min-Kook Kim
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  6. Jeong-Chae Lee
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Correspondence to Jeong-Chae Lee.

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Kook, SH., Cheon, SR., Kim, JH. et al. Dietary hydroxycinnamates prevent oxidative damages to liver, spleen, and bone marrow cells in irradiation-exposed mice. Food Sci Biotechnol 26, 279–285 (2017). https://doi.org/10.1007/s10068-017-0037-y

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  • DOI: https://doi.org/10.1007/s10068-017-0037-y

Keywords

  • total body irradiation
  • reactive oxygen species
  • bone marrow
  • radioprotection
  • phenolic compounds