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Lipid-lowering effects of Zanthoxylum schinifolium Siebold & Zucc. seed oil (ZSO) in hyperlipidemic rats and lipolytic effects in 3T3-L1 adipocytes

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Abstract

On the basis of the antiatherosclerotic effect of Zanthoxylum schinifolium, the therapeutic potential of Zanthoxylum schinifolium seed oil (ZSO) was tested in terms of the blood lipid profile and obesity in rats. The lipolytic effects of ZSO were determined in adipocytes and the total body and liver weight were decreased in rats. Compared with the high-cholesterol high-fat (HCHF) group, the rats in the HCHF+ZSO group showed improved levels of hyperlipidemia indicators. Furthermore, western blot analysis confirmed that the improvement of hyperlipidemia indicators was induced by stimulation of lipoprotein lipase expression. Additional results indicated that the reduction in body weight was likely caused by phosphorylation of hormone-sensitive lipase (HSL) via the protein kinase A pathway, ultimately leading to lipolysis. In conclusion, the results of the in vivo experiment showed that ZSO improved the lipid profiles in the blood, lowering cardiovascular disease and arteriosclerosis and degrading cellular lipids by activating HSL.

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Authors and Affiliations

  1. Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon, 24341, Korea

    Kyoung Kon Kim & Myeon Choe

  2. Well-Being Bioproducts R&D Regional Innovation Center, Kangwon National University, Chuncheon, Gangwon, 24341, Korea

    Tae Woo Kim, Dae Jung Kim & Myeon Choe

  3. Applied Product Development Team, National Development Institute of Korean Medicine, Gyeongsan, Gyeongbuk, 38540, Korea

    Yun Hwan Kang

Authors
  1. Kyoung Kon Kim
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  2. Tae Woo Kim
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  3. Yun Hwan Kang
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  4. Dae Jung Kim
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  5. Myeon Choe
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Correspondence to Myeon Choe.

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Kim, K.K., Kim, T.W., Kang, Y.H. et al. Lipid-lowering effects of Zanthoxylum schinifolium Siebold & Zucc. seed oil (ZSO) in hyperlipidemic rats and lipolytic effects in 3T3-L1 adipocytes. Food Sci Biotechnol 25, 1427–1436 (2016). https://doi.org/10.1007/s10068-016-0222-4

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  • DOI: https://doi.org/10.1007/s10068-016-0222-4

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