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Effect of supplementation of low-molecular-weight chitosan oligosaccharide, GO2KA1, on postprandial blood glucose levels in healthy individuals following bread consumption

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Abstract

The effect of chitosan oligosaccharide (GO2KA1) administration on postprandial blood glucose levels of subjects with normal blood glucose levels was evaluated following bread consumption. Postprandial blood glucose levels were determined for 2 h after bread ingestion with or without 500 mg of GO2KA1. GO2KA1 significantly lowered the mean, maximum, and minimum levels of postprandial blood glucose at 30 min after the meal. Postprandial blood glucose levels were decreased by about 25% (from 155.11±13.06 to 138.50±13.59, p<0.01) at 30 min when compared to control. Furthermore, we observed that the area under the concentration-time curve (AUCt) was decreased by about 6% (from 255.46±15.43 to 240.15±14.22, p<0.05) and the peak concentration of blood glucose (C max) was decreased by about 11% (from 157.94±10.90 to 140.61±12.52, p<0.01) when compared to control. However, postprandial the time to reach C max (Tmax) levels were the same as those found in control. Our findings suggest that GO2KA1 limits the increase in postprandial blood glucose levels following bread consumption.

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Authors and Affiliations

  1. Department of Nutrition, University of Massachusetts, Amherst, MA, 01003, USA

    Jung-Bae Oh, Justin S. Kim & Young-Cheul Kim

  2. Kunpoong Bio Co., Ltd, Jeju, 63016, Korea

    Jong-Wook Lee

  3. Department of Chemistry and Food Science, Framingham State University, Framingham, MA, 01701, USA

    Sung-Hoon Jo, Kyoung-Soo Ha & Emmanouil Apostolidis

  4. Department of Food and Nutrition, Hannam University, Daejeon, 34054, Korea

    Yu-Ri Kang, Hwang-Yong Choi, Jung-Yun Lee, Soo-In Jang, Mee-Sook Lee & Young-In Kwon

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  1. Yu-Ri Kang
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  2. Hwang-Yong Choi
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  3. Jung-Yun Lee
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  4. Soo-In Jang
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  5. Jung-Bae Oh
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  6. Justin S. Kim
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  7. Jong-Wook Lee
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  8. Sung-Hoon Jo
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  9. Kyoung-Soo Ha
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  10. Mee-Sook Lee
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  11. Young-Cheul Kim
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  12. Emmanouil Apostolidis
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  13. Young-In Kwon
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Correspondence to Young-In Kwon.

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Kang, YR., Choi, HY., Lee, JY. et al. Effect of supplementation of low-molecular-weight chitosan oligosaccharide, GO2KA1, on postprandial blood glucose levels in healthy individuals following bread consumption. Food Sci Biotechnol 25, 911–914 (2016). https://doi.org/10.1007/s10068-016-0149-9

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  • DOI: https://doi.org/10.1007/s10068-016-0149-9

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