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Beneficial role and function of fisetin in skin health via regulation of the CCN2/TGF-β signaling pathway

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Abstract

Skin is composed of multiple layers, including the epidermis, dermis, and hypodermis. Although several biological activities of fisetin have been reported, beneficial effects and the functions of fisetin in skin remain unclear. B16F10 melanoma cells, human skin fibroblasts, and 3T3-L1 cells were used to examine the beneficial effects of fisetin in skin health. α-MSH- and IBMX-induced melanosis in B16F10 melanoma cells was inhibited by fisetin treatment, which also enhanced mRNA expression levels of skin fibril-related genes via the CCN2/TGF-β signaling pathway. Decreased intracellular lipid accumulation via down-regulation of transcriptional factors through activation of the CCN2/TGF-β signaling pathway was observed. A novel function of fisetin in skin health via down-regulation of melanosis and adipogenesis, and up-regulation of skin fibril-related genes was observed. Evidence for development of nutri-cosmetics for skin health is presented.

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Authors and Affiliations

  1. Department of Food, Nutrition and Biotechnology, Kyungnam University, Changwon, 51767, Korea

    Myung-Soo Shon, Ryeong-Hyeon Kim & Gyo-Nam Kim

  2. Daegyeong Institute for Regional Industry Evaluation, Daegyeong Institute for Regional Program Evaluation, Daegu, 38542, Korea

    O. Jun Kwon

  3. Department of Herbology, Daegu Haany University, Daegu, 42158, Korea

    Seong-Soo Roh

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  1. Myung-Soo Shon
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  2. Ryeong-Hyeon Kim
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  3. O. Jun Kwon
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  5. Gyo-Nam Kim
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Correspondence to Gyo-Nam Kim.

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Shon, MS., Kim, RH., Kwon, O.J. et al. Beneficial role and function of fisetin in skin health via regulation of the CCN2/TGF-β signaling pathway. Food Sci Biotechnol 25 (Suppl 1), 133–141 (2016). https://doi.org/10.1007/s10068-016-0110-y

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  • DOI: https://doi.org/10.1007/s10068-016-0110-y

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