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Food Science and Biotechnology

, Volume 25, Issue 1, pp 253–260 | Cite as

Chlorogenic acid decreased intestinal permeability and ameliorated intestinal injury in rats via amelioration of mitochondrial respiratory chain dysfunction

  • Yan Zhou
  • Zheng RuanEmail author
  • Lili Zhou
  • Yuhui Yang
  • Shumei Mi
  • Zeyuan Deng
  • Yulong Yin
Article

Abstract

Chlorogenic acid (CGA), an abundant polyphenol compound in plants, exhibits anti-oxidant effects. The protective effect of CGA in the rat intestine with endotoxin infusion was evaluated. CGA administration ameliorated endotoxin-induced intestinal injury, and decreased the ratio of lactulose/mannitol, the ileum pathological grade, the myeloperoxidase activity in the ileum, and the malondialdehyde content in the ileum and in ileum mitochondria. The small intestine weight, activities of alkaline phosphatase and superoxide dismutase in the ileum, and β-nicotinamide adenine dinucleotide reduce form (NADH) dehydrogenase and succinate dehydrogenase activities in ileum mitochondria were increased. Intestinal permeability was positively correlated with intestinal mitochondrial injury indicated as the level of malondialdehyde in ileum mitochondria, and negatively correlated with NADH dehydrogenase activity. Dietary administration of CGA protected against increased intestinal permeability caused by endotoxin infusion. The protective effect of CGA was probably associated with a decrease in mitochondrial lipid peroxidation levels and an increase in NADH dehydrogenase activity.

Keywords

Chlorogenic acid intestinal permeability intestinal injury mitochondria respiration chain enzyme 

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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Yan Zhou
    • 1
    • 2
  • Zheng Ruan
    • 1
    • 2
    Email author
  • Lili Zhou
    • 1
    • 2
  • Yuhui Yang
    • 1
    • 2
  • Shumei Mi
    • 1
    • 2
  • Zeyuan Deng
    • 1
    • 2
  • Yulong Yin
    • 1
    • 2
    • 3
  1. 1.State Key Laboratory of Food Science and TechnologyNanchang UniversityNanchangChina
  2. 2.School of Food Science and TechnologyNanchang UniversityNanchangChina
  3. 3.Institute of Subtropical AgricultureChinese Academy of SciencesChangshaChina

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