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Hepatoprotective effect of Diospyros lotus leaf extract against acetaminophen-induced acute liver injury in mice

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Abstract

The aim of this study was to investigate the protective effect of Diospyros lotus leaf extract (DLE) against acetaminophen (APAP)-induced acute liver injury in mice. Administration of DLE significantly attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in APAP-treated mice. Histopathological examination showed that DLE treatment decreased the incidence of liver lesions in APAP-treated mice. DLE treatment markedly increased superoxide dismutase, catalase, glutathione peroxidase activity, and glutathione levels in APAP-treated mice. Furthermore, DLE treatment significantly suppressed the production of proinflammatory factors such as the nitric oxide, IL-6, TNF-α, and iNOS in APAP-treated mice. These results suggest that DLE protects the liver from APAP-induced hepatic injury via antioxidant and antiinflammatory effects.

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Correspondence to Seon Il Jang.

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Cho, B.O., Yin, H.H., Fang, C.Z. et al. Hepatoprotective effect of Diospyros lotus leaf extract against acetaminophen-induced acute liver injury in mice. Food Sci Biotechnol 24, 2205–2212 (2015). https://doi.org/10.1007/s10068-015-0294-6

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  • DOI: https://doi.org/10.1007/s10068-015-0294-6

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