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A partially purified lipid extracted from Ruditapes philippinarum suppresses cancer cell proliferation

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Abstract

Anticancer effects of lipids from a clam cultivated in Korea were investigated. Hexane extracts of Ruditapes philippinarum (R. philippinarum) exhibited the highest apoptosis rate of 40.9% at 0.5 mg/mL in PC3 cells. Hexane extracts were further separated and purified using TLC. Final lipid compounds were isolated and identified. Monounsaturated fatty acid and polyunsaturated fatty acid levels were significantly (p<0.05) increased in the purified lipid (19.71 and 34.63%), compared with the crude extract (12.96 and 15.56%). Partially purified lipid compounds exhibited an anticancer effect in several cancer cell lines, resulting in apoptosis rates in breast, lung, and liver cancer cells of 37.36, 17.78, 26.56%, respectively, at 30 µg/mL. This is the first report of an anticancer effect of a lipid extracted from R. philippinarum cultivated in Korea.

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Authors and Affiliations

  1. Division of Food Bio Science and Korea Nokyong Research Center Konkuk University, Chungju, Chungbuk, 27478, Korea

    Eun-Kyung Kim, Sang-Ho Moon & Byong-Tae Jeon

  2. Department of Biotechnology, Konkuk University, Chungju, Chungbuk, 27478, Korea

    Yon-Suk Kim, Jin-Woo Hwang & Pyo-Jam Park

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  1. Eun-Kyung Kim
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  2. Yon-Suk Kim
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  6. Pyo-Jam Park
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Correspondence to Pyo-Jam Park.

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Kim, EK., Kim, YS., Hwang, JW. et al. A partially purified lipid extracted from Ruditapes philippinarum suppresses cancer cell proliferation. Food Sci Biotechnol 24, 2177–2183 (2015). https://doi.org/10.1007/s10068-015-0290-x

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  • DOI: https://doi.org/10.1007/s10068-015-0290-x

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