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Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells

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Abstract

Sulforaphane significantly (p<0.05) inhibited tumor necrosis factor (TNF)-α induced cellular migration and invasion in MCF10DCIS.com human breast cancer cells, compared with controls. mRNA and protein expressions of MMPs, including MMP-2, MMP-9, and MMP-13, and the enzymatic activities of MMP-2 and MMP-9 were suppressed by sulforaphane treatments at 1, 5, and 10 μM concentration in MCF10DCIS.com cells. Sulforaphane should be considered as a potent agent for retardation of mammary tumorigenesis.

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Authors and Affiliations

  1. Department of Food Science and Technology, Chung-Ang University, Anseong, Gyeonggi, 456-756, Korea

    Cheng Bao, Jiwon Ko, Hyun-Chang Park, Min Chae Kim, Joong-Hyuck Auh & Hong Jin Lee

  2. Department of Integrative Plant Science, Chung-Ang University, Anseong, Gyeonggi, 456-756, Korea

    Jongkee Kim

Authors
  1. Cheng Bao
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  2. Jiwon Ko
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  3. Hyun-Chang Park
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  4. Min Chae Kim
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  5. Jongkee Kim
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  6. Joong-Hyuck Auh
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  7. Hong Jin Lee
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Correspondence to Hong Jin Lee.

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Bao, C., Ko, J., Park, HC. et al. Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells. Food Sci Biotechnol 24, 347–351 (2015). https://doi.org/10.1007/s10068-015-0046-7

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  • DOI: https://doi.org/10.1007/s10068-015-0046-7

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