Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells

Abstract

Sulforaphane significantly (p<0.05) inhibited tumor necrosis factor (TNF)-α induced cellular migration and invasion in MCF10DCIS.com human breast cancer cells, compared with controls. mRNA and protein expressions of MMPs, including MMP-2, MMP-9, and MMP-13, and the enzymatic activities of MMP-2 and MMP-9 were suppressed by sulforaphane treatments at 1, 5, and 10 μM concentration in MCF10DCIS.com cells. Sulforaphane should be considered as a potent agent for retardation of mammary tumorigenesis.

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Correspondence to Hong Jin Lee.

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Bao, C., Ko, J., Park, H. et al. Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells. Food Sci Biotechnol 24, 347–351 (2015). https://doi.org/10.1007/s10068-015-0046-7

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Keywords

  • breast cancer
  • invasion
  • matrix metalloproteinase
  • migration
  • sulforaphane