Skip to main content
SpringerLink
Log in

Neuroprotective effect of Reseda luteola L. extract in a mouse neuronal cell model

  • Research Article
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

Aqueous extracts of Reseda luteola L. used as a dyeing agent for centuries have antioxidant activities. The neuroprotective effect of aqueous herb extracts were investigated against glutamate-induced reactive oxygen species (ROS) insult using mouse hippocampal HT22 and cortical neural cells. Aqueous extracts and the hexane fraction of R. luteola L. effectively attenuated the cytotoxicity of glutamate (5 mM) in both HT22 and primary neural cells derived from the mouse cortex. The neuroprotective effect was attributable to unidentified components and luteolin, which is known as a biologically active constituent. Aqueous extracts of R. luteola L. deserve further study for identification of active components and development of food colorants with health benefits.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cerrato A, De Santis D, Moresi M. Production of luteolin extracts from Reseda luteola and assessment of their dyeing properties. J. Sci. Food Agr. 82: 1189–1199 (2002)

    Article  CAS  Google Scholar 

  2. Lucas CD, Allen KC, Dorward DA, Hoodless LJ, Melrose LA, Marwick JA, Tucker CS, Haslett C, Duffin R, Rossi AG. Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway. FASEB J. 27: 1084–1094 (2013)

    Article  CAS  Google Scholar 

  3. Kim JS, Kwon CS, Son KH. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotech. Bioch. 64: 2458–2461 (2000)

    Article  CAS  Google Scholar 

  4. Kim SH, Shin KJ, Kim D, Kim YH, Han MS, Lee TG, Kim E, Ryu SH, Suh PG. Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts. Biochem. Pharmacol. 66: 955–963 (2003)

    Article  CAS  Google Scholar 

  5. Woelfle U, Simon-Haarhaus B, Merfort I, Schempp CM. Reseda luteola L. Extract displays antiproliferative and pro-apoptotic activities that are related to its major flavonoids. Phytother. Res. 24: 1033–1036 (2010)

    CAS  Google Scholar 

  6. Jang S, Dilger RN, Johnson RW. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J. Nutr. 140: 1892–1898 (2010)

    Article  CAS  Google Scholar 

  7. Casetti F, Jung W, Wolfle U, Reuter J, Neumann K, Gilb B, Wahling A, Wagner S, Merfort I, Schempp CM. Topical application of solubilized Reseda luteola extract reduces ultraviolet B-induced inflammation in vivo. J. Photoch. Photobio. B 96: 260–265 (2009)

    Article  CAS  Google Scholar 

  8. Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787–795 (2006)

    Article  CAS  Google Scholar 

  9. Villela A, van der Klift EJ, Mattheussens ES, Derksen GC, Zuilhof H, van Beek TA. Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). J. Chromatogr. A 1218: 8544–8550 (2011)

    Article  CAS  Google Scholar 

  10. Peng B, Zi JQ, Yan WD. Measurement and correlation of solubilities of luteolin in organic solvents at different temperatures. J. Chem. Eng. Data 51: 2038–2040 (2006)

    Article  CAS  Google Scholar 

  11. Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radical Bio. Med. 27: 612–616 (1999)

    Article  CAS  Google Scholar 

  12. Waak J, Dringen R. Formation and rapid export of the monochlorobimane-glutathione conjugate in cultured rat astrocytes. Neurochem. Res. 31: 1409–1416 (2006)

    Article  CAS  Google Scholar 

  13. Seelinger G, Merfort I, Schempp CM. Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med. 74: 1667–1677 (2008)

    Article  CAS  Google Scholar 

  14. Zhang YC, Gan FF, Shelar SB, Ng KY, Chew EH. Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury. Food Chem. Toxicol. 59: 272–280 (2013)

    Article  CAS  Google Scholar 

  15. Zhao G, Yao-Yue C, Qin GW, Guo LH. Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons. Neurobiol. Aging 33: 176–186 (2012)

    Article  CAS  Google Scholar 

  16. Li S, Li X, Rozanski GJ. Regulation of glutathione in cardiac myocytes. J. Mol. Cell Cardiol. 35: 1145–1152 (2003)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Food Science and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea

    Seong Soon Kim, Ji Yeon Seo & Jong-Sang Kim

  2. Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Soon Sung Lim

  3. Gyeongbuk Natural Color Industry Institute, Youngcheon, Gyeongbuk, 770-060, Korea

    Hwa Jin Suh

  4. Whasoomok Company, Yeongcheon, Gyeongbuk, 770-831, Korea

    Lione Kim

Authors
  1. Seong Soon Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ji Yeon Seo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Soon Sung Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hwa Jin Suh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lione Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jong-Sang Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jong-Sang Kim.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, S.S., Seo, J.Y., Lim, S.S. et al. Neuroprotective effect of Reseda luteola L. extract in a mouse neuronal cell model. Food Sci Biotechnol 24, 333–339 (2015). https://doi.org/10.1007/s10068-015-0044-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-015-0044-9

Keywords

Search

Navigation