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In vitro efficacy evaluation for prevention of diabetes and diabetic complications using Aster sphathulifolius

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Abstract

The efficacy of Aster sphathulifolius (AS) for evaluation of preventive potencies against diabetes and diabetic complications was analyzed by assessment of inhibitory effects against advanced glycation end-products (AGEs) formation, rat lens aldose reductase (RLAR), α-glucosidase activity, and scavenging effects against DPPH. The 50% ethanol extract showed the highest DPPH radical scavenging activity (82.38%) at a concentration of 100 μg/mL, exhibited the most potent AGEs formation inhibitory effect (93.88%) at a concentration of 200 μg/mL, showed the most potent RLAR inhibitory effect (86.44%) at a concentration of 11.11 μg/mL. The 95% ethanol extract showed a potent α-glucosidase inhibitory activity (19.16%) at a concentration of 1 mg/mL. The 50% ethanol extract value was 16.79%. The 50% ethanol extract exhibited the most potent antioxidant and preventive actions against diabetes and diabetic complications and can, thus, be a source of valuable compounds for prevention of diabetes and diabetic complications.

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Authors and Affiliations

  1. Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Xing Fu Yin, Young Eun Jeon, Jae-Hoon Shim & Il-Jun Kang

  2. Newtree Co., Ltd., Seongnam, Gyeonggi, 462-120, Korea

    Hee Chul Chung

  3. Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul, 130-701, Korea

    Se Young Choung

Authors
  1. Xing Fu Yin
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  2. Young Eun Jeon
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  3. Hee Chul Chung
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  4. Se Young Choung
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  5. Jae-Hoon Shim
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  6. Il-Jun Kang
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Correspondence to Il-Jun Kang.

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Yin, X.F., Jeon, Y.E., Chung, H.C. et al. In vitro efficacy evaluation for prevention of diabetes and diabetic complications using Aster sphathulifolius . Food Sci Biotechnol 24, 301–306 (2015). https://doi.org/10.1007/s10068-015-0040-0

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  • DOI: https://doi.org/10.1007/s10068-015-0040-0

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