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Effects of blue mussel (ME) water extracts on pentobarbital-induced sleep and the sleep architecture in mice

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Abstract

Blue mussel (Mytilus edulis) is a popular shellfish that is used widely in the daily diet. It has antioxidant, antimicrobial, and anticoagulant properties. The hypnotic effects of blue mussel (ME) water extracts in a mouse model were investigated. Oral administration of ME water extracts produced a dose-dependent decrease in sleep latency and an increase in sleep duration in pentobarbital-treated mice. At concentrations of 500 and 1,000 mg/kg, the extracts also increased the sleep onset rate (90 and 90%, respectively) and sleep duration (46.3±4.9 and 58.3±2.0 min, respectively) in sub-hypnotic dosage testing. Electroencephalograms (EEG) and electromyograms (EMG) showed that ME water extracts reduced sleep latency and induced non-rapid eye movement sleep (NREMS) while maintaining rapid eye movement sleep (REMS). ME water extracts did not affect the EEG power density. ME water extract-induced sleep is similar to physiological sleep in a mouse model.

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Authors and Affiliations

  1. Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, 608-737, Korea

    Quang Van Ta, Young-Sang Kim & Sun-Joo Park

  2. Korea Food Research Institute, Seongnam, Gyeonggi, 463-746, Korea

    Minseok Yoon, Hyejin Yang, Jiyoung Kim & Suengmok Cho

  3. Marince Bioprocess Research Center, Pukyong National University, Busan, 608-737, Korea

    Kyong-Hwa Kang

  4. Specialized Graduate School Science and Technology Convergence, Pukyong National University, Busan, 608-739, Korea

    Se-Kwon Kim

Authors
  1. Quang Van Ta
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  2. Minseok Yoon
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  3. Hyejin Yang
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  4. Jiyoung Kim
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  7. Young-Sang Kim
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  8. Sun-Joo Park
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  9. Se-Kwon Kim
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Correspondence to Se-Kwon Kim.

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Ta, Q.V., Yoon, M., Yang, H. et al. Effects of blue mussel (ME) water extracts on pentobarbital-induced sleep and the sleep architecture in mice. Food Sci Biotechnol 24, 295–300 (2015). https://doi.org/10.1007/s10068-015-0039-6

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  • DOI: https://doi.org/10.1007/s10068-015-0039-6

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