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Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells

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Abstract

Bioactivities of peel and flesh extracts of 3 genetically diverse mango (Mangifera indica L.) varieties were studied. Nam Doc Mai peel extracts, containing the largest amounts of polyphenols, were associated with an effect on MCF-7 viable cell numbers with an IC50 (dose required for 50% inhibition of cell viability) of 56 μg/mL and significantly (p<0.01) induced cell death in MDA-MB-231 cells, compared with other varieties. Hydrophilic fractions of Nam Doc Mai peel extracts had the highest bioactivity values against both MCF-7 and MDA-MB-231 cells. Soluble polyphenols were present in the largest amounts in most hydrophilic fractions. The Nam Doc Mai mango variety contains high levels of fruit peel bioactivity, which appears to be related to the nature of the polyphenol composition.

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Authors and Affiliations

  1. School of Pharmacy, The University of Queensland, Brisbane, Queensland, 4072, Australia

    Van Le Thu Hoang, Jean-Thomas Pierson, Merril Carmel Curry, Paul Nicholas Shaw, Ralf Georg Dietzgen, Sarah Jane Roberts-Thomson & Gregory Raymond Monteith

  2. Queensland Alliance for Agriculture and Food Innovation, Centre for Nutrition and Food Sciences, The University of Queensland, Queensland, Brisbane, 4072, Australia

    Van Le Thu Hoang, Paul Nicholas Shaw, Ralf Georg Dietzgen & Michael John Gidley

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  1. Van Le Thu Hoang
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  2. Jean-Thomas Pierson
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  3. Merril Carmel Curry
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  4. Paul Nicholas Shaw
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  7. Sarah Jane Roberts-Thomson
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  8. Gregory Raymond Monteith
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Correspondence to Gregory Raymond Monteith.

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Hoang, V.L.T., Pierson, JT., Curry, M.C. et al. Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells. Food Sci Biotechnol 24, 265–271 (2015). https://doi.org/10.1007/s10068-015-0035-x

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  • DOI: https://doi.org/10.1007/s10068-015-0035-x

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