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A functional egg yolk powder containing an antibody against Niemann-Pick C1-like1 (NPC1L1) lowers cholesterol levels in high cholesterol diet induced hypercholesterolemic SD rats

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Abstract

Niemann-Pick C1-Like 1 (NPC1L1) plays an important role in intestinal cholesterol absorption, and is a promising therapeutic target for treatment of hypercholesterolemia. A functional egg yolk powder containing an antibody against NPC1L1 (FEY) was investigated for lowering cholesterol levels in high cholesterol diet induced hypercholesterolemic rats. Male Sprague-Dawley rats (5 weeks old) were fed with control, high cholesterol (HCD), HCD+0.1% FEY, HCD+1% FEY, or HCD+5% FEY diets for 6 weeks. There was no effect of FEY on body weight gain, food intake, or liver, kidney, and spleen weights in hypercholesterolemic rats. FEY lowered total cholesterol and LDL-cholesterol serum levels, and the atherogenic index. FEY decreased hepatic cholesterol levels and hepatic lipid accumulation. Fecal cholesterol levels were increased by administration of FEY, which has potential as a cholesterol lowering agent for treatment of hypercholesterolemia.

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Authors and Affiliations

  1. Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Dae Hwan Kim, Mi-Ran Choi, Ji Eun Hong, Jae-Yong Lee & Eun Ji Kim

  2. Department of Biochemistry, College of Medicine, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Jae-Yong Lee

  3. Research and Development Center, Adbiotech Co., Ltd., Chuncheon, Gangwon, 200-883, Korea

    Hyuck-Se Kwon, Sang-Ho Jang & Eun Ji Kim

Authors
  1. Dae Hwan Kim
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  2. Mi-Ran Choi
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  3. Ji Eun Hong
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  4. Jae-Yong Lee
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  5. Hyuck-Se Kwon
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  6. Sang-Ho Jang
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  7. Eun Ji Kim
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Correspondence to Eun Ji Kim.

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Kim, D.H., Choi, MR., Hong, J.E. et al. A functional egg yolk powder containing an antibody against Niemann-Pick C1-like1 (NPC1L1) lowers cholesterol levels in high cholesterol diet induced hypercholesterolemic SD rats. Food Sci Biotechnol 24, 217–223 (2015). https://doi.org/10.1007/s10068-015-0029-8

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  • DOI: https://doi.org/10.1007/s10068-015-0029-8

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